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Forschungsschwerpunkt

Due to accelerating climate change and the resulting rapid increase in extreme environmental conditions, the question of how plants can flexibly adapt to their constantly changing environment is a highly topical area of research. Plants, being sessile organisms, have evolved a plethora of mechanisms to be able to respond quickly and accurately to their surroundings. The plasma membrane serves as boundary between the inside and the outside of the cell and is densely packed with proteins that are responsible for sensing and transmitting stimuli. Plants thus have to be able to rapidly and accurately adjust not only the localization but also the amount of their plasma membrane proteins. This is organized by endosomal trafficking, which transports membrane proteins to and from their site of action. Here, the post-translational modification of plasma membrane proteins with the small protein ubiquitin is key in signaling their removal from the plasma membrane by endocytosis and further degradation in the vacuole. To understand the significance and the variety of roles played by this reversible modification, the function of ubiquitin receptors, which translate the ubiquitin signature into a cellular response, needs to be elucidated. In this lab we try to unravel the function of the TOM1-like (TOL) protein family in the recognition and in initiating sorting to the vacuole of ubiquitinated plasma membrane proteins destined for degradation. The TOL proteins function in plants as multivalent ubiquitin receptors, governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport (ESCRT) pathway.

Degradation of membrane proteins Protein trafficking Phytohormones Adaptation

 

Laufbahn

  • 2022 Institute head IMPB
  • 2022 - 2024 Vice Head of Department (DAGZ)
  • 2020 venia docendi "molecular cell biology"
  • 2018 Principal Investigator at the Department of Applied Genetics and Cell Biology
  • 2015 - 2017 Elise Richter position
  • 2010 - 2014 Hertha Firnberg position

Auszeichnungen

  • : 2014 : BOKU Best Paper Award des Jubiläumsfonds der Stadt Wien

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Publikationen

Wissentransfer in die Gesellschaft

Medienbeiträge

Vorträge

Es wurden 11 gefunden.

  • : 2022 - TOL proteins-ubiquitin receptors in early endocytic trafficking

    Art:   Vortrag - Keynote Speaker (eingeladener Vortrag)

    Autoren: Barbara Korbei

    : International Conference on Plant Proteostasis

  • : 2019 - The role of TOL proteins, ubiquitin receptors of the endosomal degradation pathway during abiotic stress response

    Art:   Poster - Ausgewählte Präsentation

    Autoren: Schwihla M., Moulinier-Anzola J. and Korbei B.

    : 22nd Meeting of the European Network for Plant Endomembrane Research

    : 03.09.2019 - 06.09.2019  | : Valencia, Spain

  • : 2019 - Function and regulation of TOLs: ubiquitin receptors in the endosomal system of plants

    Art:   Poster - Ausgewählte Präsentation

    Autoren: Moulinier-Anzola J., De-Araújo, L., Schwihla M., Artner C., Jörg L and Korbei B.

    : 11th Tri-National Arabidopsis Meeting TNAM 2019

    : 10.04.2019 - 12.04.2019  | : Zürich, Switzerland

  • : 2019 - Function and regulation of TOLs: ubiquitin receptors in the endosomal system.

    Art:   Vortrag - Ausgewählte Präsentation

    Autoren: Barbara Korbei

    : International Conference on Plant Proteostasis University of Freiburg

    : 10.09.2019 - 13.09.2019  | : Freiburg im Breisgau, Germany

  • : 2019 - Wissenschaftstag für Volksschulkinder

    Art:   Vortrag - Ausgewählte Präsentation

    Autoren: Moulinier-Anzola J., Lucyshyn D., Feraru E., Strauss-Goller S., Schwihla M., Dünser K. and Korbei B.

    : Kinderuni 2019

    : 17.06.2019 - 18.06.2019  | : Vienna, Austria

  • : 2018 - Function and regulation of the ubiquitin binding TOL proteins and their impact on plasma membrane protein downregulation

    Art:   Poster - Ausgewählte Präsentation

    Autoren: De-Araújo L., Moulinier-Anzola J., Schwihla M., Artner C., Jörg L., Podgorschek E. and Korbei B.

    : 21st Meeting of the European Network for Plant Endomembrane Research ENPER 2018

    : 04.09.2018 - 07.09.2018  | : Vienna, Austria

  • : 2017 - Ubiquitin binding and conjugation is important for the function and localization of th e TOLs

    Art:   Poster - Ausgewählte Präsentation

    Autoren: Lucinda De-Araújo, Jeanette Moulinier-Anzola, Lisa Jörg, Christina Artner and Barbara Korbe

    : European Network for Plant Endomembrane Research

    : 12.09.2017 - 15.09.2017  | : Prague, Czech Republic | : Bordeaux, France | : Bordeaux, France

  • : 2017 - Ubiquitin binding and conjugation is important for the function and localisation of TOL proteins

    Art:   Vortrag - Ausgewählte Präsentation

    Autoren: Barbara Korbei

    : From Proteome to Phenotype SEB 2017 - role of post-translational modifications

    : 11.12.2017 - 13.12.2017  | : Edinburgh, Scotland, UK

  • : 2015 - Wiener Töchtertag

    Art:   Vortrag - Ausgewählte Präsentation

    Autoren: Barbara Korbei

    : http://www.toechtertag.at/

    : 01.04.2015  | : Vienna, Austria

  • : 2015 - Structure-Function Analysis of conserved ubiquitin binding domains in TOL proteins.

    Art:   Poster - Ausgewählte Präsentation

    Autoren: Lucinda De-Araujo, Christina Artner, Jeanette Moulinier-Anzola and Barbara Korbei

    : EMBO Conference 2015 - Signalling in plant development

    : 20.09.2015 - 24.09.2015  | : Brno, Czech Republic

  • : 2014 - Wissenschaftstag für Volksschulkinder

    Art:   Vortrag - Ausgewählte Präsentation

    Autoren: Barbara Korbei, Christian Luschnig

    : Wissenschaftstag für Volksschulkinder, Kinderuni 2014

    : 02.05.2014  | : Vienna, Austria

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