COMPREHENSIVE CHEMICAL PROFILING AND BIOPHYSICAL CHARACTERIZATION OF EMERGING BIOPHARMACEUTICALS USING NATIVE MULTI-DIMENSIONAL LIQUID CHROMATOGRAPHY
Abstract
deCIPHER envisions the development of a native multi-dimensional liquid chromatography platform and explore its possibilities for comprehensive chemical profiling and biophysical characterization of monoclonal antibody variants in a continuous downstream processing workflow. This involves the development of unique biomimetic column technology and its implementation in the native MD-LC platform. Finally, the potential of the deCIPHER technology will be assessed, to study aberrant translational effects of IgG mAbs, for the first time, and for the comprehensive characterization of emerging secretory Immunoglobulin A in a DSP workflow.
keywords Immunglobolin-A Chromatography Ion Exchange Hydrophobic Interaction Chromatography
Publikationen
Project staff
Alois Jungbauer
Univ.Prof. Dipl.-Ing. Dr.nat.techn. Alois Jungbauer
alois.jungbauer@boku.ac.at
Tel: +43 1 47654-79096
Project Leader
01.05.2022 - 30.04.2026
Rainer Hahn
Assoc. Prof. Dipl.-Ing. Dr. Rainer Hahn
rainer.hahn@boku.ac.at
Tel: +43 1 47654-79094
Project Staff
01.05.2022 - 30.04.2026
Nico Lingg
Dipl.-Ing. Dr. Nico Lingg Bakk.techn.
nico.lingg@boku.ac.at
Tel: +43 1 47654-79115
Project Staff
01.05.2022 - 30.04.2026