Statistical analysis of genetic imprintig effects on quantitative traits in cattle.
Abstract
Scientific question of the project: Genetic imprinting is an epigenetically determinated process by which genes transmitted by females or males are specifically marked which may cause a different degree of gene expression. Hence, offspring who receive such marked genes from their dams may be different in their phenotyp from those who receive the same genes from their sires. Until now, research of the imprinting phenomenon was mainly on qualitative traits of transgenic laboratory animals (especially in mouse) or human diseases and indicated that about 10 to 15 % of the investigated genomes are affected by genetic imprintig. However, most of the relevant traits in livestock production are quantitative characters which are mostly determinated by a multitude of diverse gene loci. The scientific question of the project can therefore be summerazid as: 'To which extend occurs paternal and/or maternal genetic imprinting on quantitative characters in cattle?' Methods: The estimation of genetic and epigenetic effects on quantitative traits reqiures appropriate quantitative statistical methods. In theory, a REML (Resticted Maximum Likelihood) procedure on the basis of an suitable gametic model or a model where gametes are treated as homozygous diploid individuals is the adequate estimation approach for this problem. An appropriate computer program should be available until 1999. Its reliability will be proved in the project by a separate Monte Carlo study. Additionaly, some other estimation approaches basing on the expexted covariance between various relatives is also intended.
keywords imprinting cattle
Publikationen
Nicht alle Gene halten sich an Mendels Regeln.
Autoren: Eßl, A. Jahr: 2000
Newspaper / Magazine article
Genomic imprinting effects on dairy- and fitness-related traits in cattle
Autoren: Essl, A; Voith, K Jahr: 2002
Journal articles
Project staff
Johann Sölkner
Univ.Prof. Dipl.-Ing. Dr.nat.techn. Johann Sölkner
johann.soelkner@boku.ac.at
Tel: +43 1 47654-93201, 93231
Project Staff
01.04.1998 - 31.03.2001