Development of conjugate vaccines with S-layers. (S7206-MOB)

Institute of Colloid and Biointerface Science

01.05.1994 - 31.10.1999

Research project (§ 26 & § 27)

Program none

Funder none

Competencies

Abstract

Crystalline cell surface layers (S-layers) possess a broad application potential in biotechnology and medicine. The goal of the project is to assess the applicability of native and cross-linked S-layers as carrier and adjuvants for the development of conjugate vaccines.

Publications

Oligodeoxynucleotides containing immunostimulatory sequences modulate the allergic Th2-response to Bet v 1, the major birch pollen allergen, in mice.

Autoren: Jahn-Schmid, B., Wiedermann, U., Bohle, B., Messner, P., Sleytr, U. B., Kraft, D., Ebner, C. Jahr: 1998

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Applications of S-layers.

Autoren: Sleytr, UB; Bayley, H; Sára, M; Breitwieser, A; Küpcü, S; Mader, C; Weigert, S; Unger, FM; Messner, P; Jahn-Schmid, B; Schuster, B; Pum, D; Douglas, K; Clark, NA; Moore, JT; Winningham, TA; Levy, S; Frithsen, I; Pankovc, J; Beale, P; Gillis, HP; Choutov, DA; Martin, KP Jahr: 1997

Journal articles

external links and characteristics of the publication:
Crystalline bacterial cell surface layers as combined adjuvants for conjugate vaccines.

Autoren: Schäffer, C.-R., Jahn-Schmid, B., Graninger, M., Zenker, A., Unger, F. M., Sleytr, U. B., Messner, P. Jahr: 1997

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Towards selective elicitation of Th1-controlled vaccination responses.

Autoren: Jahn-Schmid, B., Messner, P., Unger, F. M., Sleytr, U. B., Scheiner, O., Kraft, D. Jahr: 1995

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Crystalline bacterial cell surface layers (S-layers) as carriers for Streptococcus pneumoniae vaccines.

Autoren: Schäffer, C., Zenker, A., Messner, P., Unger, F. M., Sleytr, U. B. Jahr: 1996

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Crystalline bacterial cell surface layers (S-layers): from supramolecular cell structure to biomimetics and nanotechnology.

Autoren: Sleytr, U. B., Messner, P., Pum, D., Sara, M. Jahr: 1999

Journal articles

external links and characteristics of the publication:
Konjugierte Impfstoffe auf der Basis von S-Schichten.

Autoren: Messner, P., Unger, F. M. Jahr: 1999

Forschungsbericht (extern. Auftraggeber)

external links and characteristics of the publication:
Vaccine development based on S-layer technology.

Autoren: Messner, P., Unger, F. M., Sleytr, U. B. Jahr: 1996

Chapter in collected volumes

external links and characteristics of the publication:
Toward selective elicitation of TH1-controlled vaccination responses: vaccine applications of bacterial surface layer proteins.

Autoren: Jahn-Schmid, B; Messner, P; Unger, FM; Sleytr, UB; Scheiner, O; Kraft, D Jahr: 1996

Journal articles

external links and characteristics of the publication:

dx.doi.org
Immunoreactivity of allergen (Bet v 1) conjugated to crystalline bacterial cell surface layers (S-layers).

Autoren: Jahn-Schmid, B; Graninger, M; Glozik, M; Küpcü, S; Ebner, C; Unger, FM; Sleytr, UB; Messner, P Jahr: 1996

Journal articles

external links and characteristics of the publication:
Crystalline bacterial cell surface layers (S-layers) as carriers for Streptococcus pneumoniae vaccines.

Autoren: Schäffer, C., Palme, S., Kirchmayr, R., Messner, P., Unger, F. M., Sleytr, U. B. Jahr: 1998

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Bet v 1, the major birch pollen allergen, conjugated to crystalline bacterial cell surface proteins, expands allergen-specific T cells of the Th1/Th0 phenotype in vitro by induction of IL-12.

Autoren: Jahn-Schmid, B; Siemann, U; Zenker, A; Bohle, B; Messner, P; Unger, FM; Sleytr, UB; Scheiner, O; Kraft, D; Ebner, C Jahr: 1997

Journal articles

external links and characteristics of the publication:
Cytokine induction by potential vaccine-carriers based on bacterial membranes.

Autoren: Fürst-Ladani, S., Lubitz, W., Haslberger, A., Messner, P., Sleytr, U. B., Redl, H., Schlag, G. Jahr: 1997

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Mögliche Verwendung von bakteriellen S-Schicht-Proteinen als Träger/Adjuvans für die spezifische Immuntherapie: Modulation der allergenspezifischen Th2-Antwort.

Autoren: Jahn-Schmid, B., Siemann, U., Bohle, B., Zenker, A., Messner, P., Unger, F. M., Kraft, D., Sleytr, U. B., Ebner, C. Jahr: 1997

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Modulation of Th2-like responses in type I allergy using crystalline bacterial cell surface layers (S-layers) as allergen carriers/adjuvants.

Autoren: Jahn-Schmid, B., Siemann, U., Bohle, B., Zenker, A., Messner, P., Unger, F. M., Sleytr, U. B., Kraft, D., Ebner, C. Jahr: 1997

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Vaccine applications of crystalline bacterial surface layer proteins (S-layers).

Autoren: Jahn-Schmid, B., Messner, P., Sleytr, U. B., Ebner, C., Unger, F. M. Jahr: 1996

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Hapten-specific immune responses elicited by conjugates of synthetic tumor-associated glycans with crystalline bacterial surface layer proteins (S-layers).

Autoren: Smith, R. H., Messner, P., Sleytr, U. B., Unger, F. M. Jahr: 1996

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Crystalline bacterial cell surface layers (S-layers) as carrier-adjuvants for selective Th1-vaccination responses. Applicability in the immunotherapie of allergies?

Autoren: Jahn-Schmid, B., Siemann, U., Messner, P., Unger, F. M., Sleytr, U. B., Kraft, D., Ebner, C. Jahr: 1995

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Modulation of the allergic Th2-response in mice using different bacterial adjuvants: oligonucleotides (ODN) and bacterial surface layer proteins (SL).

Autoren: Jahn-Schmid, B., Wiedermann, U., Bohle, B., Messner, P., Unger, F. M., Sleytr, U. B., Kraft, D., Ebner, C. Jahr: 1998

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Crystalline bacterial cell surface layers (S-layers) as carrieradjuvants for selective Th1-responses: possible application for immunotherapy of Type 1 allergy?

Autoren: Jahn-Schmid, B., Siemann, U., Bohle, B., Messner, P., Unger, F. M., Sleytr, U. B., Kraft, D., Ebner, C. Jahr: 1996

Conference & Workshop proceedings, paper, abstract

external links and characteristics of the publication:
Bacterial cell envelopes (ghosts) and LPS but not bacterial S-layers induce synthesis of immune-mediators in mouse macrophages involving CD14.

Autoren: Haslberger, A. G., Mader, H. J., Schmalnauer, M., Kohl, G., Szostak, M. P., Messner, P., Sleytr, U. B., Wanner, G., Fürst-Ladani, S., Lubitz, W. Jahr: 1997

Journal articles

external links and characteristics of the publication:
Konjugierte Impfstoffe auf der Basis von S-Schichten.

Autoren: Messner, P., Unger, F. M. Jahr: 1998

Forschungsbericht (extern. Auftraggeber)

external links and characteristics of the publication:
Kristalline Zelloberflächen-Schichten prokaryotischer Organismen (S-Schichten): von der supramolekularen Zellstruktur zur Biomimetik und Nanotechnologie.

Autoren: Sleytr, U B; Messner, P; Pum, D; Sara, M Jahr: 1999

Journal articles

external links and characteristics of the publication:
Bacterial S-layers.

Autoren: Sleytr, UB; Beveridge, TJ Jahr: 1999

Journal articles

external links and characteristics of the publication:
Bacterial cell envelopes (ghosts) but not S-layers activate human endothelial cells (HUVECs) through sCD14 and LBP mechanism.

Autoren: Fürst-Ladani, S; Redl, H; Haslberger, A; Lubitz, W; Messner, P; Sleytr, UB; Schlag, G Jahr: 1999

Journal articles

external links and characteristics of the publication:

Project staff

Paul Messner

Ao.Univ.-Prof.i.R. Dipl.-Ing.Dr.nat.techn. Paul Messner
paul.messner@boku.ac.at

Project Leader

01.05.1994 - 31.10.1999

Beatrice Jahn-Schmid

Dr. Beatrice Jahn-Schmid

Project Staff

01.05.1994 - 31.10.1999

Christina Schäffer

Univ.Prof. Dipl.-Ing.Dr.nat.techn. Christina Schäffer
christina.schaeffer@boku.ac.at
Tel: +43 1 47654-80203

Project Staff

01.05.1994 - 31.10.1999

BOKU partners

Institute of Colloid and Biointerface Science

role coordinator

External partners

INSERM U419-Nantes, Institut de Biologie

Dr. Jacques Le Pendu

partner

AKH, Institut für Allgemeine und Experimentelle Pathologie

Prof. Dr. Dietrich Kraft

partner

Development of conjugate vaccines with S-layers. (S7206-MOB)

Abstract

Publications

Oligodeoxynucleotides containing immunostimulatory sequences modulate the allergic Th2-response to Bet v 1, the major birch pollen allergen, in mice.

Applications of S-layers.

Crystalline bacterial cell surface layers as combined adjuvants for conjugate vaccines.

Towards selective elicitation of Th1-controlled vaccination responses.

Crystalline bacterial cell surface layers (S-layers) as carriers for Streptococcus pneumoniae vaccines.

Crystalline bacterial cell surface layers (S-layers): from supramolecular cell structure to biomimetics and nanotechnology.

Konjugierte Impfstoffe auf der Basis von S-Schichten.

Vaccine development based on S-layer technology.

Toward selective elicitation of TH1-controlled vaccination responses: vaccine applications of bacterial surface layer proteins.

Immunoreactivity of allergen (Bet v 1) conjugated to crystalline bacterial cell surface layers (S-layers).

Crystalline bacterial cell surface layers (S-layers) as carriers for Streptococcus pneumoniae vaccines.

Bet v 1, the major birch pollen allergen, conjugated to crystalline bacterial cell surface proteins, expands allergen-specific T cells of the Th1/Th0 phenotype in vitro by induction of IL-12.

Cytokine induction by potential vaccine-carriers based on bacterial membranes.

Mögliche Verwendung von bakteriellen S-Schicht-Proteinen als Träger/Adjuvans für die spezifische Immuntherapie: Modulation der allergenspezifischen Th2-Antwort.

Modulation of Th2-like responses in type I allergy using crystalline bacterial cell surface layers (S-layers) as allergen carriers/adjuvants.

Vaccine applications of crystalline bacterial surface layer proteins (S-layers).

Hapten-specific immune responses elicited by conjugates of synthetic tumor-associated glycans with crystalline bacterial surface layer proteins (S-layers).

Crystalline bacterial cell surface layers (S-layers) as carrier-adjuvants for selective Th1-vaccination responses. Applicability in the immunotherapie of allergies?

Modulation of the allergic Th2-response in mice using different bacterial adjuvants: oligonucleotides (ODN) and bacterial surface layer proteins (SL).

Crystalline bacterial cell surface layers (S-layers) as carrieradjuvants for selective Th1-responses: possible application for immunotherapy of Type 1 allergy?

Bacterial cell envelopes (ghosts) and LPS but not bacterial S-layers induce synthesis of immune-mediators in mouse macrophages involving CD14.

Konjugierte Impfstoffe auf der Basis von S-Schichten.

Kristalline Zelloberflächen-Schichten prokaryotischer Organismen (S-Schichten): von der supramolekularen Zellstruktur zur Biomimetik und Nanotechnologie.

Bacterial S-layers.

Bacterial cell envelopes (ghosts) but not S-layers activate human endothelial cells (HUVECs) through sCD14 and LBP mechanism.

Project staff

Paul Messner

Beatrice Jahn-Schmid

Christina Schäffer

BOKU partners

Institute of Colloid and Biointerface Science

External partners

INSERM U419-Nantes, Institut de Biologie

AKH, Institut für Allgemeine und Experimentelle Pathologie

Funder

Austrian Science Fund (FWF)