Chemo-enzymatic synthesis of sugar-based polymers
Abstract
The object of the project is to synthesize novel polymers using oxidized sugars, that are prepared by enzyme technology, as the starting material. For this bioctalytic part it is planned to employ the cellobiose-oxidizing enzyme cellobiose dehydrogenase from S. rolfsii for the selective oxidation of various di- and trisaccharides (e.g., cellobiose, maltose, cellotriose, maltotriose, etc.) at the anomeric carbon to obtain the corresponding carboxylic acid derivatives in gram quantities. These oxidized derivatives will then be transformed into the corresponding aminoamides via a lactone intermediate. The amino sugars will be used as co-monomers for the preparation of polymeric poly-amidoamines, compounds that are usually bio-compatible and that therefore can be used as drug carrier polymers, the sugar appendages being selective receptor targets.
keywords cellobiose dehydrogenase laccase biocompatible polymers
Publikationen
Project staff
Dietmar Haltrich
Univ.Prof. Dipl.-Ing. Dr.techn. Dietmar Haltrich
dietmar.haltrich@boku.ac.at
Tel: +43 1 47654-75211
Project Leader
01.01.2004 - 31.12.2005
Clemens Karl Peterbauer
Assoc. Prof. Dr. Clemens Karl Peterbauer
clemens.peterbauer@boku.ac.at
Tel: +43 1 47654-75212
Sub Projectleader
01.01.2004 - 31.12.2005
BOKU partners
External partners
Consiglio Nazionale delle Ricerche
Dr. Sergio RIVA
partner