Vera Pfanzagl
Dipl.-Ing. Vera Pfanzagl Ph.D.
Institute of Biochemistry
Location Muthgasse 18, 1190 Wien
Email vera.pfanzagl@boku.ac.at
Tel: +43 1 47654-77279
ORCID: 0000-0002-9361-8365, opens in new window.
AuthorId : 57200222267, opens in new window.
ResearcherId : AAE-9025-2019
Research Focus
We study the structure-function relationship of human heme peroxidases using a combination of biochemical analysis, X-ray crystallography and molecular biology. Currently we focus on three proteins, Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) from the innate immune response and Thyroid peroxidas (TPO), the main enzyme catalyzing thyroid hormone production. We want to unravel the fine differences between MPO and EPO to understand their divergent function and to find exploitable structural traits for design of new selective inhibitors. The membrane bound TPO on the other hand, is not only essential for hormone biosynthesis but also a main auto-antigen in Hashimotos disease, where constant attack by auto-antibodies leads to a degradation of the thyroid gland. Here we focus on solving the crystal structure and understanding the properties of TPO in detail to understand the high prevalence of TPO associated autoimmune diseases.
Career
- 2024 Elise-Richter Fellow (Department of Chemistry, BOKU)
- 2019 - 2024 Post-Doc (Department of Chemistry, BOKU)
- 2015 - 2019 Dissertation withing the international PhD programme BioToP at the Department of Chemistry, BOKU
- 2015 Technician at the Department for Applied Genetics and Cell Biology, BOKU
- 2014 FEMtech internship at the Department for Applied Genetics and Cell Biology, BOKU
- 2011 master thesis at the NIBR Novartis, Switzerland
- 2011 - 2014 Master Biotechnology (BOKU)
- 2007 - 2011 Bachelor Food- and Biotechnology (BOKU)
Projects
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Publications
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Knowledge Transfer to Society
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Presentations
List by country with the number of lectures given there:
- Austria+' '+1
- Brazil+' '+2
- Croatia+' '+1
- Czech+' '+1
- France+' '+2
- Germany+' '+2
- Hungary+' '+6
- Iceland+' '+1
- Ireland+' '+3
- Italy+' '+1
- Poland+' '+2
- Spain+' '+1
- Switzerland+' '+4
- United Kingdom+' '+2
29 lecures found.
Year: 2024 - Myeloperoxidase dimerization in solution is mediated by interface glycans
Art: Poster - Selected presentation
Autoren: Leitgeb, U; Furtmüller, PG; Obinger, C; Pfanzagl, V
Event: 34th European Crystallographic Meeting 2024
Period: 26.08.2024 - 30.08.2024 | Location: Padua, Italien | Organizer: European Crystallographic Association
Year: 2023 - Reactivity and protein-protein interaction of human peroxidasin 1
Art: Talk - Selected presentation
Autoren: Furtmüller, PG, Paumann-Page, M; Pfanzagl, V; Hofbauer, S; Obinger, C
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer: Semmelweis Egyetem
Year: 2023 - Reconstitution and linkage of heme in thyroid peroxidase post-purification
Art: Poster - Selected presentation
Autoren: Parzer, B; Furtmüller, PG; Obinger, C; Pfanzagl, V
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer: Semmelweis Egyetem
Year: 2023 - First crystal structure of eosinophil peroxidase reveals suptile distinctions in the active site architecture and processing
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Leitgeb, U; Grünwald-Gruber, C; Furtmüller, PG; Obinger, C
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer: Semmelweis Egyetem
Year: 2023 - The inhibitory protein SPIN reduces the halide oxidation rate of myeloperoxidase but leaves the substrate binding site unaffected
Art: Talk - Selected presentation
Autoren: Leitgeb, U; Brito, JA; Furtmüller, PG; Obinger, C; Pfanzagl, V
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer: Semmelweis Egyetem
Year: 2023 - Testing the incorporation efficiency of phenylalanine derivatives with dual fluorescent reporter proteins
Art: Poster - Selected presentation
Autoren: Terzer, F; Leitgeb, U; Marin, Z; Kani, A.A; Wiltschi, B; Pfanzagl, V; Obinger, C
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer: Semmelweis Egyetem
Year: 2022 - Biochemistry of Enzymes Involved in the Coproporphyrin-Dependent Heme Biosynthesis Pathway of Gram-Positive Bacteria
Art: Talk - Keynote Speaker (Invited Speaker)
Autoren: Hofbauer, S; Gabler, T; Patil, G; Michlits, H; Pfanzagl, V; Obinger, C; Furtmüller, PG
Event: Gordon Research Conference - Chemistry and Biology of Tetrapyrroles
Period: 17.07.2022 - 22.07.2022 | Location: Newport, Rhode Island, USA
Year: 2022 - Structural and mechanistic insights in dimeric chlorite dismutase - Impact of pH and the dynamics of the catalytic arginine
Art: Talk - Selected presentation
Autoren: Schmidt, D; Serra, I; Hofbauer, S; Pfanzagl, V; Van Doorslaer, S; Obinger, C; Furtmüller, P.G.
Event: 16th European Biological Inorganic Chemistry 2022
Period: 17.07.2022 - 21.07.2022 | Location: Grenoble, France
Year: 2022 - New insights into B-class dye-decolorizing peroxidases: tracing radical sites with electron paramagnetic resonance
Art: Talk - Keynote Speaker (Invited Speaker)
Autoren: Van Doorslaer, S; Nys, K; Furtmüller, PG; Obinger, C; Pfanzagl, V;
Event: 12th International Conference on Porphyrins and Phtalocyanines ICPP-12 2022
Period: 10.07.2022 - 15.07.2022 | Location: Madrid, Spain
Year: 2022 - Reactivity of peroxidases and chlorite dismutases with chlorite and hypochlorite: a spectroscopic investigation of short-lived intermediates trapped by fast freeze-quenching
Art: Talk - Selected presentation
Autoren: Serra, I; Schmidt, D; Hofbauer, S; Pfanzagl, V; García-Rubio, I; Furtmüller, PG; Obinger C; and Van Doorslaer, V;
Event: The 55th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry 2022
Period: 06.06.2022 - 10.06.2022 | Location: St. Andrews, Scotland, UK
Year: 2022 - X-ray induced reduction of heme metal centers is protein-independent
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Beale, JH; Michlits, H; Schmidt, D; Gabler, T; Obinger, C; Djinovic-Carugo, K; Hofbauer, S;
Event: 33rd European Crystallographic Meeting
Period: 23.08.2022 - 27.08.2022 | Location: Versailles, France
Year: 2021 - Coproporphyrin ferrochelatase – study of relevant residues for substrate and product binding
Art: Talk - Selected presentation
Autoren: Gabler, T; Pfanzagl, V; Obinger, C; Furtmüller PG; Hofbauer, S
Event: International Conference on Porphyrins and Phthalocyanines - ICPP11
Period: 28.06.2021 - 03.07.2021 | Location: Online
Year: 2019 - X-ray induced redcution kinetics of heme metal centers is protein-independent
Art: Poster - Selected presentation
Autoren: Pfanzagl, V; Beale, J; Schmidt, D; Michlits, H; Gabler, T; Djinovic-Carugo, K; Obinger, C; Hofbauer, S
Event: 11th Human Peroxidase Meeting
Period: 04.09.2019 - 07.09.2019 | Location: Brno, Czech Republic
Year: 2019 - Posttranslational Modification of Heme in Peroxidases - Impact on Structure and Function
Art: Talk - Selected presentation
Autoren: Furtmüller, PG; Nicolussi, A; Sevcnikar, B; Paumann-Page, M; Auer, M; Zamocky, M; Pfanzagl, V; Hofbauer, S; Obinger, C
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2019 - An actinobacterial representative sheds a new light on the reaction mechanism of coproheme decarboxylases
Art: Poster - Selected presentation
Autoren: Michlits, H; Pfanzagl, V; Furtmüller, PG; Djinovic-Carugo, K; Obinger, C; Hofbauer, S
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2019 - YfeX - A new player involved in the redox gated potassium efflux pump KefC
Art: Poster - Selected presentation
Autoren: Pfanzagl, V; Schwaiger, L; Michlits, H; Hofbauer, S; Obinger, C
Event: Gordon Research Conference: Mechanisms of Membrane Transport
Period: 23.06.2019 - 28.06.2019 | Location: New London, UK
Year: 2019 - X-ray induced redcution kinetics of heme metal centers is protein-independent - implications for structural studies of redox sensitive proteins
Art: Poster - Selected presentation
Autoren: Pfanzagl, V; Beale, J; Schmidt, D; Michlits, H; Gabler, T; Djinovic-Carugo, K; Obinger, C; Hofbauer, S
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2019 - X-ray induced reduction of heme metal centers is protein-independent – implications for structural studies of redox sensitive proteins
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Beale, JH; Schmidt, D; Michlits, H; Gabler, T; Djinovic-Carugo, C; Obinger, C; Hofbauer, S
Event: Hot Topics in Crystallography 4
Period: 01.10.2019 - 06.10.2019 | Location: Dubrovnik, Croatia
Year: 2019 - Molecular mechanism of coproheme to heme b conversion
Art: Talk - Selected presentation
Autoren: Hofbauer, S; Milazzo, L; Gabler, T; Pühringer, D; Pfanzagl, V; Djinovic-Carugo, K; Furtmüller, PG; Obinger, C; Smulevich, G
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2018 - Kinetic and spectroscopic characterization of EfeB
Art: Poster - Selected presentation
Autoren: Michlits, H., Pfanzagl, V., Schwaiger, L., Furtmüller, P. G., Hofbauer, S., Obinger, C.
Event: OxiZymes 2018
Period: 08.07.2018 - 10.07.2018 | Location: Belfast, Northern Ireland, UK
Year: 2018 - Mechanistic Studies on Coproheme Decarboxylase
Art: Poster - Selected presentation
Autoren: Hofbauer, S; Milazzo, L; Mlynek, G; Gabler, T; Howes, BD; Pfanzagl, V; Djinović-Carugo, K; Furtmüller, PG; Smulevich, G; Obinger, C
Event: Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
Period: 01.07.2018 - 06.07.2018 | Location: Munich, Germany
Year: 2018 - Crystal and Electronic Structure of Compound I in Dye-decolorizing Peroxidases
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Hofbauer, S; Beale, J; Mlynek, G; Michlits, H; Nys, K; Van Doorslaer, S; Djinovic-Carugo, K; Furtmüller, PG; Obinger, C
Event: Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
Period: 01.07.2018 - 06.07.2018 | Location: Munich, Germany
Year: 2018 - On Compound I formation in B-type dye decolorizing peroxidases - lessons from structural and kinetic studies.
Art: Talk - Selected presentation
Autoren: Pfanzagl, V., Nys, K., Mlynek, G., Djinović-Carugo, K., Van Doorslaer, S., Furtmüller, P. G., Hofbauer, S., Obinger, C.
Event: OxiZymes 2018
Period: 08.07.2018 - 10.07.2018 | Location: Belfast, Northern Ireland, UK
Year: 2018 - Coproheme decarboxylases – phylogenetic prediction versus biochemical analysis.
Art: Talk - Selected presentation
Autoren: Pfanzagl, V., Holcik, L., Maresch, D., Michlits, H., Furtmüller, P. G., Obinger, C., Hofbauer, S.
Event: OxiZymes 2018
Period: 08.07.2018 - 10.07.2018 | Location: Belfast, Northern Ireland, UK
Year: 2017 - Roles of the distal Asp-Arg pair in Compound I formation of K. pneumoniae dye-decolorizing peroxidase
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Hofbauer, S; Nys, K; Djinovic-Carugo, K; Battistuzzi, G; Van Doorslaer, S; Furtmuller, PG; Obinger, C
Event: International Conference on Bioinorganic Chemistry ICBIC-18 2017
Period: 31.07.2017 - 04.08.2017 | Location: Florianopolis, Brazil
Year: 2017 - Roles of the distal Asp-Arg pair in compound I formation of K. pneumoniae dye-decolorizing peroxidase
Art: Poster - Selected presentation
Autoren: Pfanzagl, V; Hofbauer, S; Nys, K; Djinović-Carugo, K; Battistuzzi, G; Van Doorslaer, S; Furtmüller, P.G; and Obinger, C;
Event: International Conference on Bioinorganic Chemistry ICBIC-18 2017
Period: 31.07.2017 - 04.08.2017 | Location: Florianopolis, Brazil
Year: 2016 - Dye decolorizing peroxidases - A new heme-peroxidase family with ancient roots
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Schaffner, I; Hofbauer, S; Furtmuller, P; Obinger, C
Event: European Congress on Biotechnology 2016
Period: 03.07.2016 - 06.07.2016 | Location: Krakow, Poland | Organizer: European Federation of Biotechnology
Year: 2016 - Dye decolorizing peroxidases – a new heme-peroxidase family with ancient roots
Art: Talk - Selected presentation
Autoren: Pfanzagl, V; Schaffner, I; Hofbauer, S; Furtmüller, P.G; Obinger, C
Event: 17th European Congress on Biotechnology ECB17 2016
Period: 03.07.2016 - 06.07.2016 | Location: Krakow, Poland
Year: 2016 - Dye-decolorizing peroxidases – a new heme-peroxidase family with ancient roots
Art: Poster - Selected presentation
Autoren: Pfanzagl, V., Furtmüller, P. G., Obinger, C. 2016. Dye-decolorizing peroxidases – a new heme-peroxidase family with ancient roots
Event: 13th European Biological Inorganic Chemistry Conference EuroBIC 2016
Period: 28.08.2016 - 01.09.2016 | Location: Budapest, Hungary
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