Michael Traxlmayr

Presentations

• Year: 2024 -  Engineering of molecular ON- and OFF-switches for controlling CAR T cells

  Autoren: Zajc, CU; Sumesgutner, D; Mayer, J; Sylvander, E; Teufl, M; Traxlmayr, MW

  Event: EBMT-EHA 6th European CAR T-cell Meeting

• Year: 2023 -  Engineering molecular switches for functional control of CAR T cells with an orally available small molecule drug.

  Autoren: Zajc, CU; Dobersberger, M; Schaffner, I; Mlynek, G; Pühringer, D; Salzer, B; Djinović-Carugo, K; Obinger, C; Lehner, M; Traxlmayr, MW

  Event: EHA-EBMT 5th European CAR T-cell Meeting

• Year: 2023 -  Novel protein engineering strategies for next-generation CAR T-cells.

  Autoren: Traxlmayr, MW

  Event: Janssen R&D Symposium on Next-Generation Cell Therapy

• Year: 2023 -  Unraveling the FMC63-CD19 affinity

  Autoren: Seigner, J; Zajc, CU; Dötsch, S; Eigner, C; Laurent, E; Busch, DH; Lehner, M; Traxlmayr, MW

  Event: Keystone meeting on Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy

• Year: 2023 -  Incorporating drug regulated switch modules to improve the safety of cellular therapies.

  Autoren: Traxlmayr, MW

  Event: Gamma Delta T Therapies Summit, Boston

• Year: 2023 -  Novel protein engineering concepts to improve the safety and specificity of CAR T cells

  Autoren: Traxlmayr, MW

  Event: PEGS Boston

• Year: 2023 -  Taking control of CAR T cells- Engineering of molecular ON-switches for cellular therapies

  Autoren: Charlotte U. Zajc, Markus Dobersberger, Manfred Lehner and Michael W. Traxlmayr

  Event: ÖGMBT Annual Meeting

• Year: 2023 -  Novel Concepts to Regulate CAR T Cell Activity with Small Molecule Drugs in Vivo

  Autoren: Traxlmayr, MW

  Event: PEGS Europe

• Year: 2022 -  Entwicklung von stabilisierten CD19-Varianten für die Detektion und Affinitätsanalyse von CAR-T Zellen

  Autoren: Michael W. Traxlmayr

  Event: CAR-T Cell Network Meeting

• Year: 2022 -  PhosphoFlowSeq – a novel high-throughput kinase activity assay for the identification of drug resistance mutations in EGFR

  Autoren: Teufl, M; Wagner, A; Gold, L; Lehner, M; Obinger, C; Sykacek, P; Traxlmayr, M

  Event: PEGS Europe 2022

• Year: 2022 -  Reversible control of CAR-T therapy to reduce toxicity and improve clinical outcomes

  Autoren: Michael W. Traxlmayr

  Event: Onco Cell Therapy Summit Europe

• Year: 2020 -  Detailed analysis of lipocalin-based molecular ON-switches in biochemical assays and in CAR T cells

  Autoren: Brey, CU; Dobersberger, M; Schaffner, I; Salzer, B; Steinberger, P; De Sousa Linhares, A; Lehner, M; Traxlmayr, MW

  Event: Keystone Symposia meeting on Emerging Cellular Therapies: Cancer and Beyond

• Year: 2020 -  A conformation-specific ON-switch for controlling CAR T cells with an orally available drug

  Autoren: Brey, C.U.; Dobersberger, M.; Schaffner, I.; Salzer, B.; Obinger, C.; Holter, W.; Traxlmayr, M.W.; Lehner, M.

  Event: Keystone-Emerging cellular therapies

• Year: 2019 -  AVIDCARS - A NOVEL PLATFORM FOR INTEGRATION OF MULTIPLE INPUT SIGNALS BY ONE CAR MOLECULE

  Autoren: Salzer, B; Brey, CU; Schueller, C; Schoeber, M; Lobner, E; Dushek, O; Holter, W; Traxlmayr, MW; Lehner, M

  Event: International Conference on Lymphocyte Engineering (ICLE)

• Year: 2019 -  Construction of a molecular ON-switch for controlling CAR T cells with an orally available small molecule

  Autoren: Brey, CU; Dobersberger, M; Schaffner, I; Mlynek, G; Pühringer, D; Salzer, B; Djinović-Carugo. K; Obinger, C; Holter, W; Lehner, M; Traxlmayr, MW

  Event: PEGS Boston

• Year: 2019 -  A LIPOCALIN-BASED ON-SWITCH FOR CONTROLLING CAR T CELLS WITH AN ORALLY AVAILABLE DRUG

  Autoren: Brey, C; Dobersberger, M; Schaffner, I; Mlynek, G; P?hringer, D; Salzer, B; Djinovic-Carugo, K; Obinger, C; Holter, W; Traxlmayr, M; Lehner, M

  Event: International Conference on Lymphocyte Engineering (ICLE)

• Year: 2019 -  Moderne Krebsforschung – Neue Chancen durch personalisierte Medizin?

  Autoren: Heffeter, P; Jäger, U; Traxlmayr, M

  Event: Science Talk

• Year: 2017 -  Development of a FACS-based screening for H2O2 producing oxidoreductases using GFP derived sensors

  Autoren: Herzog, PL; Brugger, D; Sützl, L; Traxlmayr, M; Obinger, C; Haltrich, D; Peterbauer CK

  Event: 19th International Symposium on Flavins and Flavoproteins 2017

• Year: 2016 -  Structures and thermodynamics of Fcab-antigen complexes.

  Autoren: Lobner, E., Humm, A.-S., Göritzer, K., Mlynek, G., Hasenhindl, C., Traxlmayr, M., Djinoviv-Carugo, K., Obinger, C.

  Event: PEGS 2016

• Year: 2016 -  A hyperstable miniprotein as an alternative to antibodies

  Autoren: Traxlmayr, MW; Kiefer, JD; Srinivas, RR; Lobner, E; Tisdale, AW; Mehta, NK; Tidor, B; Wittrup KD

  Event: 8th ÖGMBT Annual Meeting 2016

• Year: 2014 -  A Hyperstable Minimalist Protein for Molecular Recognition

  Autoren: Traxlmayr, MW; Srinivas, RR; Lobner, E; Tidor, B; Wittrup, KD

  Event: 28th Annual Symposium of the Protein-Society 2014

• Year: 2014 -  Stability assessment on a library scale – A rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc.

  Autoren: Hasenhindl, C., Traxlmayr, M.W., Wozniak-Knopp, G ., Jones, P.C., Stadlmayr, G., Rüker, F., Obinger, C.

  Event: Human Antibodies and Hybridomas Conference 2014

• Year: 2014 -  Construction of pH-sensitive Her2 binding antibody fragment by directed evolution using yeast display

  Autoren: Lobner, E., Traxlmayr, M. W., Rueker, F., Obinger, C.

  Event: The 16th European Congress on Biotechnology

• Year: 2014 -  Directed evolution of antibody fragments for improved stability and resistance to aggregation by using yeast surface display

  Autoren: Lobner, E., Traxlmayr, M. W., Rüker, F., Obinger, C.

  Event: Human Antibodies and Hybridomas Conference 2014

• Year: 2012 -  Systematic analysis of the C-terminal loops of IgG1-Fc for their usability in Modular Antibody Engineering

  Autoren: Hasenhindl, C., Wozniak-Knopp1, G., Traxlmayr, M.W., Hackl, M., Stadlmayr, G., Rüker F. and Obinger C.

  Event: 9th International Conference on Protein Stability 2012 - From molecular level to market applications

• Year: 2012 -  Measures to Enhance Half-Life and Stability (Preconference Short Course)

  Autoren: Rüker, F; Traxlmayr, M;

  Event: Protein and Antibody Engineering Summit PEGS Europe 2012

• Year: 2012 -  Stability engineering of human IgG1-Fc to resist boiling

  Autoren: Stadlmayr, G., Schaffner, I., Traxlmayr, M., Wozniak-Knopp, G., Hasenhindl, C., Rüker, F. and Obinger, C.

  Event: 9th International Conference on Protein Stability 2012 - From molecular level to market applications

• Year: 2012 -  Stability engineering of IgG1-Fc and construction of a “protein stability landscape” by high throughput sequencing

  Autoren: Traxlmayr, M.W.Faissner, M., Hasenhindl, C., Hackl, M., Stadlmayr, G., Rüker, F. and Obinger, C.

  Event: 9th International Conference on Protein Stability 2012 - From molecular level to market applications

• Year: 2011 -  Stability engineering of human IgG1-Fc and application in modular antibody engineering

  Autoren: Hasenhindl,C., Traxlmayr, M. W., Faissner, M., Stadlmayr, G., Rüker, F., Obinger, C.

  Event: 3rd PEGS Europe Protein & Antibody Engineering Summit 2011

• Year: 2011 -  Stability-engineering of human IgG1-Fc by using yeast display

  Autoren: Traxlmayr, M. W., Faissner, M., Stadlmayr, G., Rüker, F., Obinger, C.

  Event: PEGS - Protein and Antibody Engineering Summit 2011

• Year: 2009 -  Engineered human IgG1-Fc binding to integrin

  Autoren: Traxlmayr, M., Wozniak-Knopp, G., Rüker, F., Obinger, C.

  Event: 20th IBC's Annual International Conference on Antibody Engineering 2009