Nicole Borth

Lectures

• Year: 2024 -  Assessing the impact of evolutionary pressures on the performance of AAV vector production in HEK293 cells

  Autoren: Virgolini, N; Smesnik, G; Rahimzadeh, M; Dürauer, A; Borth, N

  Event: Advancing Manufacture of Cell and Gene Therapies VIII

• Year: 2023 -  Assessing the underlying cellular response of HEK293 cells to evolutionary pressures

  Autoren: Smesnik, G; Virgolini, N; Dürauer, A; Borth, N;

  Event: 30th Annual Congress of the European Society of Cell and Gene Therapy (ESGCT)

• Year: 2023 -  Understanding cellular limitations of HEK293, Characterization of genetic and epigenetic state

  Autoren: Smesnik, G; Virgolini, N; Dürauer, A; Borth, N;

  Event: 16th Conference of Protein Expression in Animal Cells (PEACe)

• Year: 2022 -  Using triplex-forming oligos (TFOs) to repress promoter activity in Chinese Hamster Ovary (CHO) cells

  Autoren: Hussein, M; Papez, M; Baumann, M; Dhiman, H; Galosy, S; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB & Pichia & 11th International Conference on Fiber & Polymer Biotechnology IFPB 2022

• Year: 2022 -  Using triplex-forming oligos (TFOs) to repress promoter activity in Chinese Hamster Ovary (CHO) cells

  Autoren: Hussein, M; Papez, M; Baumann, M; Dhiman, H; Galosy, S; Borth, N

  Event: 14th Annual Meeting ÖGMBT 2022 - Life Sciences - now more than ever

• Year: 2022 -  Identification of transgene integration sites, their structure and epigenetic status with Cas9-targeted nanopore sequencing in CHO Cells

  Autoren: Marx, N; Leitner, K; Motheramgari, K; Borth, N

  Event: 3rd ESACT Frontiers Retreat 2022

• Year: 2022 -  Using triplex-forming oligos (TFOs) to repress promoter activity in Chinese Hamster Ovary (CHO) cells

  Autoren: Hussein, M; Papez, M; Baumann, M; Dhiman, H; Galosy, S; Borth, N,

  Event: 6th Applied Synthetic Biology in Europe ASBE 2022

• Year: 2021 -  Reducing ammonia production in CHO cell culture

  Autoren: Stor, J

  Event: ELIXIR Fluxomics training School

• Year: 2021 -  Production of biotherapeutics in the age of –omics

  Autoren: Borth, N

  Event: ECB21 - European Biotechnology Congress

• Year: 2021 -  Tuning protein expression levels by synthetic 5’-UTR RNA structures to engineer recombinant protein expression in mammalian cell factories

  Autoren: Eisenhut, P ;Mebrahtu, A; Moradi, M; Thalen, N; Klanert, G; Weinguny, M; Sandegren, A; Su, C; Hatton, D; Borth, N; Rockberg, J

  Event: Protein Expression in Animal Cells Conference

• Year: 2019 -  Genome wide target sites of triplex mediated lncRNA interactions as regulatory nodes for transcriptional regulation

  Autoren: Dhiman, H; Hernandez Lopez, I; Borth, N

  Event: International Conference on Genomes and AI: From Packing to Regulation

• Year: 2019 -  Exquisite Phenotype control

  Autoren: Borth, N

  Event: KTH Cellnova Minisymposium

• Year: 2019 -  Regulation of gene expression driven by endogenous and viral promoters in Chinese Hamster Ovary (CHO) cells using Triplex-Forming Oligonucleotides (TFOs)

  Autoren: Papeź, M; Hussein, M; Baumann, M; Dhiman, H; Nguyen Ngoc, L; Novak, N; Galosy, S; Borth, N

  Event: 11th ÖGMBT Annual Meeting 2019 - Inside the World of Biomolecules

• Year: 2019 -  Avoiding unstable transgene integration in Horizon CHO cell lines

  Autoren: Dhiman, H; Campbell, M; Melcher, M; Smith, K; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2019 -  Triplex-Forming Oligos (TFOs) to repress promoter activity in Chinese Hamster Ovary (CHO) cells

  Autoren: Hussein, M; Baumann, M; Dhiman, H; Nguyen Ngoc, L; Novak, N; Galosy, S; Borth, N

  Event: Synthetic Biology Engineering Evolution Design SEED 2019

• Year: 2019 -  Variability of biomass composition in Chinese Hamster Ovary cells

  Autoren: Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Troyer, C; Schoeny, H; Christensen, H; Köllensperger, G; Hann, S;Lewis, N; Nielsen, L; Zanghellini, J; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Darwin and Lamarck unified: how to control phenotypes without changing the genome

  Autoren: Borth, N

  Event: Recombinant Protein Production RPP10 2019

• Year: 2019 -  CHO genome news: variation, phenotypes and control

  Autoren: Borth, N

  Event: BBSRC Meeting

• Year: 2019 -  Regulation of gene expression driven by endogenous and viral promoters in Chinese Hamster Ovary (CHO) cells using Triplex-Forming Oligonucleotides (TFOs)

  Autoren: Papeź, M; Hussein, M; Baumann, M; Dhiman, H; Nguyen Ngoc, L; Novak, N; Galosy, S; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Novel Promoters Derived From CHO via In Silico And In Vitro Analysis

  Autoren: Nguyen Ngoc, L; Baumann, M; Dhiman, H; Marx, N; Jadranka, K; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2019 -  An Innovative CRISPR/AsCpf1 Screen in CHO Cells

  Autoren: Novak, N; Schmieder, V; Dhiman, H; Baumann, M; Klanert, G; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2019 -  Tuning protein expression levels in mammalian cells by synthetic 5’-UTR RNA structure

  Autoren: Eisenhut, P; Mebrahtu, A; Klanert, G; Weinguny, M; Borth, N; Rockberg, J

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  An innovative pooled CRISPR/AsCpf1 screen tackling long non-coding RNAs in Chinese Hamster Ovary cells

  Autoren: Novak, N; Schmieder, V;Dhiman, H; Baumann, M; Klanert, G; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Manipulating phenotypes by epigenetic mechanism

  Autoren: Borth, N

  Event: Biochemical and Molecular Engineering ECI Conference,

• Year: 2019 -  Genome scale science for CHO: towards better understanding and control of phenotype in cell lines and subclones

  Autoren: Borth, N

  Event: MBI Mammalian Cell Bioprocessing Course, University College London

• Year: 2019 -  Evaluation of an lncRNA Deletion Screen in CHO cells

  Autoren: Novak, N; Schmieder, V; Dhiman, H; Baumann, M; Klanert, G; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2019 -  Subclonability Enhancement of CHO leads to an Improved Growth Phenotype

  Autoren: Weinguny, M; Klanert, G; Eisenhut, P; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2019 -  Genome wide target sites of triplex mediated lncRNA interactions as regulatory nodes for transcriptional regulation

  Autoren: Dhiman, H; Hernandez Lopez, I; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Genome scale science for CHO: from chasing the high productivity miracle gene to exquisite control of phenotypes

  Autoren: Borth, N

  Event: Bioprocess International Conference 2019 - Cell Line Development

• Year: 2019 -  Subclonability Enhancement of CHO leads to an Improved Growth Phenotype

  Autoren: Weinguny, M; Klanert, G; Eisenhut, P; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Using Triplex-Forming Oligos (TFOs) to repress promoter activity in Chinese Hamster Ovary (CHO) cells

  Autoren: Hussein, M; Baumann, M; Dhiman, H; Nguyen Ngoc, L; Novak, N; Galosy, S; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  A tool for coordinated overexpression of multiple genes in CHO cells

  Autoren: Eisenhut, P; Klanert, G; Weinguny, M; Baier, L; Ivansson, D; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2019 -  Using Triplex-Forming Oligos (TFOs) to repress promoter activity in Chinese Hamster Ovary (CHO) cells

  Autoren: Hussein, M; Baumann, M; Dhiman, H; Nguyen Ngoc, L; Novak, N; Galosy, S; Borth, N

  Event: 11th ÖGMBT Annual Meeting 2019 - Inside the World of Biomolecules

• Year: 2019 -  Bioinformatic identification of CHO cold-shock genes and biological evidence of their cold-inducible promoters

  Autoren: Nguyen Ngoc, L; Novak, N; Baumann, M; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Variability of biomass composition in Chinese Hamster Ovary cells

  Autoren: Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Troyer, C; Schoeny, H; Christensen, H; Köllensperger, G; Hann, S;Lewis, N; Nielsen, L; Zanghellini, J; Borth, N

  Event: 14th Conference on Protein Expression in Animal Cells PEACE 2019

• Year: 2019 -  CRISPR-based targeted epigenetic glyco-engineering in CHO cell

  Autoren: Marx, N, Grünwald-Gruber, C; Dhiman, H; Nguyen Ngoc, L; Bydlinski, N; Hernandez Lopez, I; Klanert, G; Borth, N

  Event: 26th European Society for Animal Cell Technology ESACT Meeting 2019

• Year: 2018 -  Determination of CHO biomass composition,

  Autoren: Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Borth, N

  Event: 5th Conference on Constraint-Based Reconstruction and Analysis COBRA 2018

• Year: 2018 -  A Cross-Species siRNA Screen in Chinese Hamster Ovary Cells Identifies Novel Engineering Targets

  Autoren: Klanert, G; Borth, N

  Event: 10th ÖGMBT Annual Meeting & Biophysics Austria Annual Meeting 2018

• Year: 2018 -  Cultivation of CHO cells for biomass component quantification

  Autoren: Knez, Š; Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Zanghellini, J; Borth, N

  Event: 10th ÖGMBT Annual Meeting & Biophysics Austria Annual Meeting 2018

• Year: 2018 -  A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in CHO cells

  Autoren: Eisenhut, P; Klanert, G; Weinguny, M; Baier, L; Jadhav, V; Ivansson, D; Borth, N

  Event: 2nd ESACT Frontiers Retreat

• Year: 2018 -  Determination of maintenance energy in CHO cells

  Autoren: Thiel, I; Stor, J; Széliová, D; Ruckerbauer, D; Hanscho, M; Zanghellini, J; Borth, N

  Event: 10th ÖGMBT Annual Meeting & Biophysics Austria Annual Meeting 2018

• Year: 2018 -  CRISPR-based epigenetic editing in CHO cells

  Autoren: Marx, N; Borth, N

  Event: 2nd ESACT Frontiers Retreat

• Year: 2018 -  A CRISPR/Cas9 based engineering strategy for overexpression of multiple genes in Chinese hamster ovary cells

  Autoren: Eisenhut, P; Klanert, G; Weinguny, M; Baier, L; Jadhav, V; Ivansson, D; Borth, N

  Event: European Congress on Biotechnology ECB 2018

• Year: 2018 -  Assessment of genomic instability of diverse Chinese hamster ovary (CHO) cell lines upon long-term cultivation and subcloning

  Autoren: Baumann, M; Vcelar, S; Jadhav, J; Auer, N; Borth, N

  Event: Bioprocss Summit Europe

• Year: 2018 -  Enforcing homogeneity in a complex and heterogeneous system “It always seems impossible until it is done”

  Autoren: Borth, N

  Event: Workshop on Mammalian synthetic biology

• Year: 2018 -  Next Generation CHO

  Autoren: Borth, N

  Event: Bioprocessing Summit Europe 2018

• Year: 2018 -  A siRNA screen reveals novel engineering targets in CHO cells that boost productivity

  Autoren: Klanert, G; Borth, N

  Event: BioProcess International European Summit 2018

• Year: 2018 -  Genomic stability of CHO – karyotype variance of host cell lines, recombinant or selected cell pools and subclones

  Autoren: Baumann, M; Vcelar, S; Jadhav, V; Auer, N; Borth, N

  Event: Cell Line Development and Engineering 2018

• Year: 2018 -  Epigenetic regulation of gene expression in response to changing environment in Chinese hamster ovary cell batch culture

  Autoren: Dhiman, H; Hernandez Lopez, I; Klanert, G; Jadhav, V; Baumann, M; Auer, N; Esteve-Codina, A; Dabad, M; Gomez, J; Alioto, T;Heath, S; Borth, N

  Event: 16th ECI Cell Culture Engineering 2018

• Year: 2018 -  Variation in karyotype and chromsome numbers in CHO cell lines and subclones

  Autoren: Borth, N; Vcelar, S; Baumann, M; Jadhav, V; Melcher, M; Leisch, F

  Event: Cell Culture Engineering XVI

• Year: 2018 -  Identification of New Engineering Targets in Chinese Hamster Ovary Cells

  Autoren: Klanert, G; Fernandez, D; Weinguny, M; Eisenhut, P; Bühler, E; Melcher, M; Titus, S; Diendorfer, A; Jadhav, V; Gludovacz, E; Xiao, S;Stern, B; Lal-Nag, M; Shiloach, J; Borth, N

  Event: 18th European Congress On Biotechnology 2018

• Year: 2018 -  TARGETED EPIGENETIC GLYCO-ENGINEERING IN CHO CELLS

  Autoren: Marx, N; Dhiman, H; Hernandez Lopez, I; Klanert, G; Borth, N

  Event: 16th ECI Cell Culture Engineering 2018

• Year: 2018 -  Determination of CHO biomass composition

  Autoren: Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Borth, N,

  Event: 18th European Congress On Biotechnology 2018

• Year: 2018 -  A REFERENCE GENOME FOR THE CHINESE HAMSTER BASED ON A HYBRID ASSEMBLY STRATEGY

  Autoren: Rupp, O; MacDonald, M; Lee, S; Dhiman, H; Polson, S; Griep, S; Heffner, K; Hernandez Lopez, I; Brinkrolf, K; Jadhav, V; Samoudi, M; Hou, H; Kingham, B; Goesmann, A; Betenbaugh, M; Lewis, N; Borth, N; Lee, K

  Event: 16th ECI Cell Culture Engineering 2018

• Year: 2018 -  A paired CRISPR/AsCpf1-mediated screen tackling long non-coding RNAs in Chinese Hamster Ovary cells

  Autoren: Schmieder, V; Dhiman, H; Novak, N; Jadhav, V; Klanert, G; Baumann, M; Kildegaard, H; Borth, N

  Event: 4th Applied Synthetic Biology in Europe 2018

• Year: 2018 -  Identification of novel promoters and genetic control elements derived from Chinese hamster ovary cells

  Autoren: Nguyen Ngoc,L; Baumann, M; Dhiman, H; Hernandez Lopez, I; Borth, N

  Event: 18th European Congress On Biotechnology 2018

• Year: 2017 -  Generation on a Chinese Hamster Ovary (CHO) Genome Deletion Library

  Autoren: Schmieder, V; Jadhav, V; Kildegaard, H; Borth, N

  Event: 9th International Conference on Recombinant Protein Production RPP9 2017

• Year: 2017 -  CRISPR-based targeted epigenetic editing in CHO cells

  Autoren: Marx, N; Hernandez Lopez, I; Jadhav, V; Clarke, C; Borth, N

  Event: 25th ESACT Meeting 2017

• Year: 2017 -  A CRISPR/Cas9 based engineering tool to activate expression of multiple genes individually or in any specific combination

  Autoren: Eisenhut, P; Klanert, G; Weinguny, M; Ivansson, D; Borth, N

  Event: 20th Biochemical and Molecular Engineering 2017

• Year: 2017 -  Sugar alcohols and ketoses to enhance viability and cell growth of Chinese Hamster Ovary (CHO) cells in suspension cultures

  Autoren: Hussein, M; Baumann, M; Galosy, S; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Knock-Down of RAD21 Leads to Productivity Enhancement in Recombinant CHO Cells

  Autoren: Weinguny, M; Klanert, G; Eisenhut, P; Fernandez, D; Diendorfer, A; Jadhav, V; Lal, M; Shiloach, J; Borth, N

  Event: 13th PEACe conference

• Year: 2017 -  CHO genome stability and heterogeneity

  Autoren: Borth, N

  Event: BioProduction Congress

• Year: 2017 -  Determination of CHO Biomass Composition

  Autoren: Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Borth, N

  Event: 13th PEACe conference

• Year: 2017 -  Epigenetic regulation of gene expression in response to changing environment in Chinese hamster ovary cell batch culture

  Autoren: Dhiman, H; Hernandez Lopez, I; Klanert, G; Jadhav, V; Baumann, M; Esteve, E; Dabad, M;Gomez, J; Auer, N; Heath, S; Rico, D; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  What did we learn from all that CHO genome sequence information?

  Autoren: Borth, N

  Event: BioProcess International European Summit 2017

• Year: 2017 -  Describing and Controlling Metabolism in CHO cells by genome scale metabolic models and statistics

  Autoren: Hanscho, M; Zanghellini, J; Melcher, M; Széliová, D; Galleguillos, S; Ruckerbauer, D; Borth, N

  Event: 9th ÖGMBT Annual Meeting 2017 - Molecular and Cellular Mechanisms of Human Diseases

• Year: 2017 -  CHO in times of –omics

  Autoren: Borth, N

  Event: 13th Conference on Protein Expression in Animal Cells

• Year: 2017 -  A cross-species high-throughput siRNA screening for suspension CHO cell

  Autoren: Klanert, G; Fernandez, D; Jadhav, V; Bühler, E; Lal, M; Shiloach, J; Borth, N

  Event: 25th ESACT Meeting 2017

• Year: 2017 -  Determination of CHO Biomass Composition,

  Autoren: Széliová, D; Ruckerbauer, D; Galleguillos, S; Hanscho, M; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  A CRISPR/Cas9 based pathway engineering tool to activate expression of multiple genes individually or in any specific combination

  Autoren: Eisenhut, P; Klanert, G; Weinguny, M; Ivansson, D; Borth, N

  Event: 20th Biochemical and Molecular Engineering 2017

• Year: 2017 -  Tightly spaced transcriptome and chromatin state analyses reveal epigenetic response to a changing environment in CHO cell batch culture

  Autoren: Borth, N

  Event: 9th International Conference on Recombinant Protein Production RPP9 2017

• Year: 2017 -  Using CRISPR/Cas9 for multiplexed activation of recombinant genes in CHO: a novel tool for cell engineering

  Autoren: Eisenhut, P; Klanert, G; Weinguny, M; Jadhav, V; Ivansson, D; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Knock-Down of RAD21 Leads to Productivity Enhancement in Recombinant CHO Cells,

  Autoren: Weinguny, M; Klanert, G; Eisenhut, P; Fernandez, D; Diendorfer, A; Jadhav, V; Lal, M; Shiloach, J; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Making a long story CHOrt: systematic reconstruction of a core metabolic model of CHO

  Autoren: Galleguillos, S; Hanscho, M; Ruckerbauer, D; Borth, N; Zanghellini, J

  Event: Data-driven Biotechnology - bench, bioreactor and bedside

• Year: 2017 -  CHOmine: a browsable resource for Chinese Hamster data

  Autoren: Hanscho, M; Gerstl, MP; Zanghellini, J; Borth, N;

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  A novel siRNA aided method for CHO cell line selection

  Autoren: Diendorfer, A; Jadhav, V; Wurz, Z; Doyle, F; Eveleth, E; Borth, N

  Event: 25th ESACT Meeting 2017

• Year: 2017 -  Assessment of genomic rearrangements in Chinese Hamster Ovary (CHO) cells

  Autoren: Baumann, M; Vcelar, S; Jadhav, V; Hernandez Lopez, I; Melcher, M; Borth, N

  Event: 25th ESACT Meeting 2017

• Year: 2017 -  Generation of a Chinese Hamster Ovary Cell Deletion Library

  Autoren: Schmieder, V; Jadhav, V; Kildegaard, H; Borth, N

  Event: 20th Biochemical and Molecular Engineering 2017

• Year: 2017 -  Identification of metabolic changes in CHO cells adapted to growth in glutamine- free media

  Autoren: Ruckerbauer, D; Galleguillos, S; Hanscho, M;Széliová, D; Zanghellini, J;Borth, N

  Event: Data-driven Biotechnology - bench, bioreactor and bedside

• Year: 2017 -  Phenotypic changes in CHO based on genes involved in energy metabolism

  Autoren: Dhiman, H; Gerstl, M, Ruckerbauer, D; Hanscho, M; Himmelbauer, H; Clarke, C; Zanghellini, J; Borth, J

  Event: EMBO Conference 2017 - Chromatin and Epigenetics

• Year: 2017 -  CRISPR-based targeted epigenetic editing in Chinese Hamster Ovary cells

  Autoren: Marx, N; Hernandez Lopez, I; Jadhav, V; Clarke, C; Andersen, M; Borth, N

  Event: 13th PEACe conference

• Year: 2017 -  Identification of novel promoters and genetic control elements derived from Chinese hamster ovary (CHO) cells

  Autoren: Nguyen Ngoc, L; Baumann, M; Hernandez Lopez, I; Dhiman, H; Borth, N

  Event: 13th PEACe conference

• Year: 2017 -  GENOME-WIDE SECRETORY PROTEIN IDENTIFICATION AND ANALYSIS OF HOST CELL SUPERNATANT DYNAMICS IN CHINESE HAMSTER OVARY (CHO) CELLS

  Autoren: Jadhav, V; Maurya, P; Auer, N; Nöbauer, K; Hummel, K; Razzazi-Fazeli, E; Gerner, C; BorthN

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Evaluation of an in silico designing pipeline to predict sgRNA pairs for the CRIPSR/Cpf1 genome editing system and its application in CHO cells

  Autoren: Novak, N; Schmieder, V; Dhiman, H; Weinguny, M; Eisenhut, P; Klanert, G; Jadhav, V; Baumann, M; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  International Conference on Epigenetics and Bioengineering

  Autoren: Borth, N

  Event: International Conference on Epigenetics and Bioengineering

• Year: 2017 -  Assessment of genomic rearrangements in Chinese Hamster Ovary (CHO) cells

  Autoren: Baumann, M; Vcelar, S; Jadhav, V; Hernandez Lopez, I; Melcher, M; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Making a long story CHOrt: systematic reconstruction of a core metabolic model of CHO

  Autoren: Galleguillos, SN; Ruckerbauer, D; Hanscho, M; Borth, N; Zanghellini, J;

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  CRISPR-based targeted epigenetic editing in CHO cells

  Autoren: Marx, N; Clarke, C; Andersen, M; Borth, N; Jadhav, V

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  CHOmine: A Browseable Resource for Chinese Hamster Data

  Autoren: Hanscho, M; Gerstl, M; Zanghellini, J; Borth, N

  Event: Data-driven Biotechnology - bench, bioreactor and bedside

• Year: 2016 -  Analysis of chromosomal rearrangements in Chinese Hamster Ovary (CHO) cells

  Autoren: Baumann, M; Vcelar, S; Hernandez-Lopez, I; Jadhav, V; Melcher, M; Borth, N

  Event: European Summit of Industrial Biotechnology ESIB 2016

• Year: 2016 -  Genome-Scale Metabolic Reconstruction of CHO Cells: What’s in a Model?,

  Autoren: Ruckerbauer, D; Hanscho, M; Zanghellini, J; Borth, N

  Event: IBC's Cell Line Engineerin

• Year: 2016 -  Genome stability and what controls cell behaviour in CHO cells

  Autoren: Borth, N

  Event: Mammalian Systems Biology Workshop

• Year: 2016 -  CHO Mitochondria : A Possible Target for Engineering?

  Autoren: Dhiman, H; Gerstl, M; Himmelbauer, H; Borth, N

  Event: ECB17 - 17th European Biotechnology Congress

• Year: 2016 -  To clone or not to clone? - Wrong question. An investigation on genome heterogeneity and stability and on what controls cell behaviour

  Autoren: Borth, N

  Event: Cell Culture Engineering, Engineering Conferences International

• Year: 2016 -  Systems biology: From improving expression to understanding genomic heterogeneity and stability

  Autoren: Borth, N

  Event: Bioprocess International 2016

• Year: 2016 -  A community built, genome-scale reconstruction of CHO cell metabolism

  Autoren: Ruckerbauer, D; Hanscho, M; Zanghellini, J; Borth, N

  Event: ECB17 - 17th European Biotechnology Congress

• Year: 2016 -  CHOmine: A Browseable Resource for Chinese Hamster Data

  Autoren: Gerstl, M; Hanscho, M; Zanghellini, J; Borth, N

  Event: International Mammalian Systems Biotechnology Workshop

• Year: 2016 -  Assessment of genomic rearrangements in Chinese Hamster Ovary (CHO) cells

  Autoren: Baumann, M; Vcelar, S; Hernandez Lopez, I; Melcher, M; Borth, N

  Event: ECB17 - 17th European Biotechnology Congress

• Year: 2015 -  Metabolic Profiling of CHO-K1 Cells Adapted to Glutamine-Free Media

  Autoren: Galleguillos, S; Hanscho, M; Zanghellini, J; Ruckerbauer, D; Borth, N

  Event: 4th Conference on Constraint-Based Reconstruction and Analysis COBRA 2015

• Year: 2015 -  A Method to Stably Integrate Multiple Genetic Elements into Chinese Hamster Ovary (CHO) Cell

  Autoren: Vcelar, S; Baumann, M; Borth, N

  Event: ACIB Science Days 2015

• Year: 2015 -  Systems biology: From improving expression to understanding genomic heterogeneity and stability

  Autoren: Borth, N

  Event: Bioprocess International 2015

• Year: 2015 -  A genome-scale metabolic network reconstruction for CHO cells identifies the biochemical capacity of protein production

  Autoren: Hanscho, M; Lund, A; Ley, D; Mikael ; Baycin-Hinzal, D; Betenbaugh, M; Paglia, G; Mahmoud, A; Ruckerbauer, D; Borth, N; Zielinski, D; Bordbar, A; Nagarajan, H; Bernhard, P; Kok Siong, A; Kyriakopoulos, S; Larshmanan, M; Lee, D; Quek, L; Martinez, V; Orellana, C; Nielsen, L; Hefzi, H; Thomas, A; Gutierrezc, J; Huang, H; Lewis, N

  Event: ECI - Biochemical and Molecular Engineering XIX

• Year: 2015 -  Non-targeted workflow for metabolomic analysis of CHO cell fabrics

  Autoren: Drexler, H., Hanscho, M., Borth, N., Koellensperger, G. and Hann, S.

  Event: 11th ASAC-JunganalytikerInnenforum 2015

• Year: 2015 -  Amplified Fragment Length Polymorphism (AFLP): a New Method to Identify Large Scale Genomic Rearrangements in Chinese Hamster Ovary (CHO) Cells

  Autoren: Vcelar, S; Hernandez Lopez, I; Melcher, M; Montero Bullon, J; Auer, N; Baumann, M; Leisch, F; Borth, N

  Event: 24th ESACT 2015 - Cells, Culture, Patients, Products

• Year: 2015 -  Advancing Cell Line Development and Engineering Using the CHO genome

  Autoren: Borth, N

  Event: Cell Line Development 2015

• Year: 2015 -  Understanding Genomic Stability of CHO Cells from Cytogenetics to Sequence Variation

  Autoren: Jadhav, V

  Event: ACIB Science Days 2015

• Year: 2015 -  Utilization of Recombinase Mediated Cassette Exchange (RMCE) and alternate start codons to select for genomic “hot-spot” integration sites

  Autoren: Baumann, M; Gludovacz, E; Borth, N

  Event: 24th ESACT 2015 - Cells, Culture, Patients, Products

• Year: 2015 -  Epigenetic regulation in Chinese Hamster Ovary producer cell lines

  Autoren: Hernandez Lopez, I; Fischer, C; Feichtinger, J; Jadhav, V; Friesz, V; Hackl, M; Thallinger, G; Bock, C; Borth, N

  Event: Recombinant Protein Production - RPP8 2015

• Year: 2015 -  Understanding Genomic Stability of CHO Cells from Cytogenetics to Sequence Variation

  Autoren: Jadhav, V

  Event: IBC Life Sciences' 11th annual Cell Line Development & Engineering conference

• Year: 2015 -  Topological properties of the Metabolic Network of Chinese Hamster Ovary (CHO) cells

  Autoren: Galleguillos, S; Hanscho, M; Zanghellini, J; Borth, N

  Event: ACIB Science Days 2015

• Year: 2015 -  sxRNA aided CHO cell line development – project introduction

  Autoren: Diendorfer, A; Borth, N

  Event: ACIB Science Days 2015

• Year: 2015 -  Epigenetic regulation in Chinese Hamster Ovary Cell lines,

  Autoren: Hernandez Lopez, I; Christoph, F; Feichtinger, J; Jadhav, V; Friesz, V; Hackl, M; Thallinger, G; Bock, C; Borth, N

  Event: 24th ESACT 2015 - Cells, Culture, Patients, Products

• Year: 2015 -  Next generation genome scale information for production cell lines: impact of genome and epigenome on cell performance and epigenome on cell performance

  Autoren: Borth, N

  Event: 2nd Cell Culture & BioProcessing Forum

• Year: 2015 -  Generation of recombinant CHO cell lines with high transcription rates using Recombinase Mediated Cassette Exchange (RMCE) and alternate start codons

  Autoren: Baumann, M; Gludovacz, E; Borth, N

  Event: ACIB Science Days 2015

• Year: 2015 -  Short- and long-term epigenetic changes in Chinese Hamster Ovary cell lines

  Autoren: Borth, N

  Event: ECI - Biochemical and Molecular Engineering XIX

• Year: 2015 -  Exploiting genomic sequence information of CHO - The “CHO“ must go on

  Autoren: Baumann, M

  Event: ACIB Science Days 2015

• Year: 2014 -  Redox regulation in ER and cytosol in response to increased oxidative protein folding and ER stress

  Autoren: Delic, M; Borth, N; Landes, N; Maccani, A; Ernst, W; Puxbaum, V; Mattanovich, D; Gasser, B

  Event: CHOgenome Workshop 2014

• Year: 2014 -  How will the CHO genome project impact cell line and process development?

  Autoren: Borth N.

  Event: Bioprocess International 2014

• Year: 2012 -  Engineering of CHO cellular phenotype.

  Autoren: Borth N. Hackl M., Klanert G., Jadhav V., Grillari J.

  Event: JAACT International Meeting 2012

• Year: 2012 -  CHO-genomics.

  Autoren: Borth N.

  Event: Biotechnology in Action, Dublin City University NICB and ETCS Joint Meeting 2012

• Year: 2012 -  The role of Dicer and Drosha controlled microRNA biogenesis in CHO cells.

  Autoren: Hackl M., Jadhav V., Grillari J., Borth N.

  Event: 13th Cell Culture Engineering Conference 2012

• Year: 2012 -  The molecular regulation of miR-17-92 cluster enhancing cellular growth in CHO cells.

  Autoren: Jadhav V., Hackl M., Hernandez-Bort J., Grillari J., Borth N.

  Event: 13th Cell Culture Engineering Conference 2012

• Year: 2012 -  Computational identification of miRNA gene loci and precursor miRNA sequences in CHO cell lines.

  Autoren: Hackl M., Jadhav V., Jakobi T., Rupp O., Brinkrolf K., Goesmann A., Pühler A., Noll T., Borth N., Grillari J.

  Event: 13th Cell Culture Engineering Conference 2012

• Year: 2012 -  Using CHO genome sequence databases for miRNA engineering.

  Autoren: Borth N., Hackl M., Vaibhav J., Grillari J.

  Event: 13th Cell Culture Engineering Conference 2012

• Year: 2012 -  Analysis of the secretome of CHO cells. Cell Culture Engineering XIII, Scottsdale, USA, April 2012

  Autoren: Maurya P., Kumar N., Nöbauer K., Hummel K., Razzazi-Fazzeli E., Borth N. (2012) Analysis of the secretome of CHO cells. Cell Culture Engineering XIII, Scottsdale, USA, April 2012

  Event: 13th Cell Culture Engineering Conference 2012

• Year: 2011 -  Transcriptional profiling of optimized CHO host cell lines

  Autoren: Eva Harreither, Matthias Hackl, Johannes Pichler, Vaibhav Jadhav, Juan A. Hernandez-Bort, Helga Höflmyer, Johannes Grillari and Nicole Borth

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  Profiling of microRNA transcription during batch cultivation of CHO-K1 cells.

  Autoren: Hackl, M., Bort, JA., Jadhav, V., Harreither, E., Grillari, J., Borth, N.

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  A time course investigation of the transcriptional regulation in CHO-K1 suspension cell cultures.

  Autoren: Hernández Bort J.A. , Hackl M., Höflmayer H., Stern B., Borth N.

  Event: Recombinant Protein Production 2011

• Year: 2011 -  A CHO cell line that grows without glutamine: transcriptomic and microRNA profiles during batch culture and effects on recombinant protein production.

  Autoren: Borth

  Event: 6th Conference on Recombinant Protein Production RPP6 2011

• Year: 2011 -  Generation of a draft Chinese Hamster Reference Genome.

  Autoren: Borth

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  CHO miRNomics: small RNAs with big future in CHO cell line development

  Autoren: Hackl Matthias, Jadhav Vaibhav, Hernandez-Bort Juan-Antonio, Borth Nicole, Grillari Johannes

  Event: Optimizing Cell Line Performance Summit 2011

• Year: 2011 -  Establishment of a large scale functional screening method for microRNAs in Chinese hamster ovary cells

  Autoren: Hackl M., Jadhav V., Borth N., Grillari J.

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  Establishment of a large scale functional screening method for microRNAs in Chinese hamster ovary cells

  Autoren: Hackl Matthias, Jadhav Vaibhav, Borth Nicole, Wieser Matthias, Harreither Eva, Grillari Johannes

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: identification, annotation and profiling of miRNA as targets for cellular engineering.

  Autoren: Hackl, M., Jakobi, T., Blom, J., Doppmeier, D., Brinkrolf, K., Szczepanowski, R., Bernhart, S., Höner zu Siederdissen, C., Bort, JA., Wieser, M., Kunert, R., Jeffs, S., Hofacker, I., Goesmann, A., Pühler, A., Borth, N, Grillari, J.

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  Dynamic transcriptome profiling of two different CHO-K1 phenotypes: Comparison of Glutamine-dependent versus Glutamine-free adapted cells.

  Autoren: Bort, JA, Hackl, M., Höflmayer H., Jadhav V , Borth, N.

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  Quantitative and qualitative analysis of erythropoietin-Fc production in a high density and glutamine-free adapted CHO cell line.

  Autoren: Kumar N., Taschwer M., Hackl M., Bort JA., Pabst M., Grass J., Kunert R., Altmann F., Borth, N.

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2011 -  CHO -omics: A New Era in Cell Line Development.

  Autoren: Borth

  Event: IBC Cell Line Development 2011

• Year: 2011 -  Chinese Hamster Ovary (CHO) cell transcription profiling reveals the role of c-Myc and the mR-17-92 cluster in cellular physiology

  Autoren: Jadhav Vaibhav, Hackl Matthias, Hernandez Juan, Grillari Johannes, Borth Nicole

  Event: 40th Keystone Symposia 2011 - MicroRNAs and Non-Coding RNAs and Cancer joint with MicroRNAs and Human Disease

• Year: 2011 -  Dynamic transcriptome profiling of CHO-K1 suspension cells in batch cultures.

  Autoren: Bort, JA, Hackl, M., Höflmayer H., Jadhav V., Borth, N.

  Event: 22nd meeting of the European Society for Animal Cell Technology ESACT 2011

• Year: 2010 -  Molecular Characteristics of Optimised CHO cell lines.

  Autoren: Borth

  Event: Bioprocess International 2010

• Year: 2010 -  Micro RNAs - small RNAs with big future in Chinese Hamster Ovary cell culture technology

  Autoren: Hackl M, Brinkrolf K, Szczepanowski R, Pühler A, Grillari J, Borth N

  Event: EAPB Science to Market Conference 2010

• Year: 2010 -  Characterization of microRNA and messengerRNA expression pattern of a CHO K1 cell line adapted to growth in glutamine free medium

  Autoren: Hernandez-Bort, JA;Hackl, M; Höflmayer, H; Stern, B; Borth, N

  Event: 12th Cell Culture Engineering Conference 2010

• Year: 2010 -  Molecular Characteristics of CHO Host Cell Lines Optimised by Cell Sorter Assisted Directed Evolution.

  Autoren: Borth N., Pichler J., Hernandez Bort J.A., Hackl M., Höflmayer H., Grillari J.

  Event: 12th Cell Culture Engineering Conference 2010

• Year: 2010 -  FACS-Assisted Directed Evolution to obtain a CHOK1 host cell line growing in glutamine free medium

  Autoren: Hernandez-Bort, JA; Stern, B; Borth, N

  Event: Science to Market 2010 - Posttranslational Modifications of Proteins - Consequences and Therapeutic Use

• Year: 2010 -  Borth N. (2010) Cell Line Characterisation and Optimisation by Flow Cytometry and Cell Sorting.

  Autoren: Borth

  Event: Cell Line Development Workshop 2010

• Year: 2010 -  Molecular Characteristics of CHO Host Cell Lines Optimised by Cell Sorter Assisted Directed Evolution

  Autoren: Borth N., Hernandez Bort J.A., Hackl M., Höflmayer H., Pichler J., Grillari J.

  Event: JAACT Meeting 2010

• Year: 2010 -  Deep Sequencing of CHO microRNAs as prerequisite for a novel approach to CHO cell engineering

  Autoren: Hackl M., Brinkrolf K., SzczepanowskiR., , Pühler A., Borth N., Grillari J.

  Event: 12th Cell Culture Engineering Conference 2010

• Year: 2010 -  Profiling of microRNA and mRNA expression in CHO host cells with increased transient antibody productivity

  Autoren: Hackl M., Pichler J., Höflmayer H., Hernandez-Bort J.A., Borth N.

  Event: 12th Cell Culture Engineering Conference 2010

• Year: 2010 -  Optimisation of CHO host cell lines: properties of the perfect cell line?

  Autoren: Borth

  Event: Cell Line Development 2010

• Year: 2010 -  FACS-Assisted Directed Evolution to obtain a CHO-K1 host cell line growing in glutamine free medium

  Autoren: Hernandez-Bort, JA, Stern, B; Borth, N

  Event: Science to Market 2010 - Posttranslational Modifications of Proteins - Consequences and Therapeutic Use

• Year: 2009 -  FACS-Assisted Directed Evolution to obtain a CHOK1 host cell line growing in glutamine free medium

  Autoren: Hernandez Bort J.A., Stern B., Borth N.

  Event: PEACe Conference 2009

• Year: 2009 -  Isolation of Chinese Hamster Ovary cell subclones with increased productivity by repeated cycles of transient transfection and fluorescence activated cell sorting

  Autoren: Pichler J., Galosy S., Mott J.E., Borth N.

  Event: PEACe Conference 2009

• Year: 2009 -  A quick and simple method for extraction and measurement of intracellular nucleotide and nucleotide sugar contents of Chinese Hamster Ovary cell lines

  Autoren: Hinterkörner G., Pabst M., Grass J., Altmann F., Borth N.

  Event: PEACe Conference 2009

• Year: 2009 -  Exo70, a subunit of the exocyt complex, is involved in pre-mRNA splicing

  Autoren: Dellago H., Löscher M., Ajuh P., Ryder U., Kaisermayer C., Grillari R., Fortschegger K., Gross S., Borth N., Einsenhaber F., Lamond A.I., Grillari J.

  Event: 1st Annual Meeting of the Austrian Association of Molecular Life Sciences and Biotechnology ÖGMBT 2009

• Year: 2009 -  MicroRNAs as novel tools for CHO cell engineering: profiling of differential microRNA expression and first regulatory insights

  Autoren: Hackl M., Müller D., Borth N., Grillari J.

  Event: 21st Meeting of the European Society for Animal Cell Technology ESACT 2009

• Year: 2009 -  FACS-Assisted Directed Evolution to obtain a robust CHOK1 host cell line: a tribute to Darwin on his anniversary

  Autoren: Hernandez Bort J.A., Stern B., Borth N

  Event: 21st Meeting of the European Society for Animal Cell Technology ESACT 2009

• Year: 2009 -  MicroRNAs as novel tools for CHO cell engineering: profiling of differential microRNA expression and first regulatory insights

  Autoren: Hackl M., Müller D., Borth N., Grillari J.

  Event: 1st Annual Meeting of the Austrian Association of Molecular Life Sciences and Biotechnology ÖGMBT 2009

• Year: 2008 -  A study on the temperature dependency and time course of the cold capture secretion assay.

  Autoren: Pichler, J., Hesse, F., Wieser, M., Kunert, R., Galosy, S., Mott, J.E., Borth, N.

  Event: Cell Culture Engineering

• Year: 2008 -  Analysis of the cellular energy state during batch cultures of Chinese Hamster Ovary cells

  Autoren: Borth Nicole

  Event: Analysis of Microbial Cells at the Single Cell Level 2008

• Year: 2008 -  Improvement of lactic acid production in yeast by cell sorting

  Autoren: Minoska Valli, Michael Sauer, Paola Branduardi, Nicole Borth, Danilo Porro, and Diethard Mattanovich

  Event: 4th International Conference on Analysis of Microbial Cells at the Single Cell Level 2008

• Year: 2008 -  Analysis of transient antibody expression in CHO cells.

  Autoren: Pichler, J., Hesse, F., Galosy, S., Mott, J.E., Borth, N.

  Event: 11th International Conference Cell Culture Engineering 2008

• Year: 2008 -  A study on the temperature dependency and time course of the cold capture secretion assay.

  Autoren: Pichler, J., Hesse, F., Wieser, M., Kunert, R., Galosy, S., Mott, J.E., Borth, N.

  Event: 11th International Conference Cell Culture Engineering 2008

• Year: 2008 -  Analysis of the cellular energy state during batch cultures of Chinese Hamster Ovary Cells

  Autoren: Borth

  Event: Analysis of Microbial Cells at the Single Cell Level 2008

• Year: 2008 -  Improving protein production through a better understanding of cellular performance: the benefits of flow cytometry and cell sorting

  Autoren: Borth N.

  Event: Bioprocess International 2008

• Year: 2008 -  Analysis of transient antibody expression in CHO cells.

  Autoren: Pichler, J., Hesse, F., Galosy, S., Mott, J.E., Borth, N.

  Event: 11th International Conference Cell Culture Engineering 2008

• Year: 2008 -  Improving Protein Production through a better understanding of cellular performance: the benefits of Flow Cytometry and Cell Sorting

  Autoren: Borth Nicole

  Event: Bioprocess International 2008

• Year: 2007 -  Analysis of transient Antibody Epxression in CHO cells.

  Autoren: Pichler J., Hinterkörner G., Hesse F., Galosy S., Mott J.E., Borth N.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Flow Cytometry and Cell Sorting in Cell Line Development.

  Autoren: Borth, N.; Hinterkörner, G.; Voglauer, R.; Hesse, F.; Matej, M.; Katinger, H.

  Event: 2nd Singapore Biologics Manufacturing Conference SBMC 2007

• Year: 2007 -  Flow Cytometry and Cell Sorting in Cell Line Development

  Autoren: Nicole Borth

  Event: 1st SBE's Conference on Accelerating Biopharmaceutical Development 2007

• Year: 2007 -  Flow Cytometry and Cell Sorting in Cell Line Development

  Autoren: Borth, N.; Hinterkörner, G.; Voglauer, R.; Hesse, F.; Matej, M.; Katinger, H.

  Event: 2nd Singapore Biologics Manufacturing Conference SBMC 2007

• Year: 2007 -  Flow Cytometry and Cell Sorting in Cell Line Development

  Autoren: Nicole Borth

  Event: 2nd Singapore Biologics Manufacturing Conference SBMC 2007

• Year: 2007 -  Analysis of transient Antibody Epxression in CHO cells

  Autoren: Pichler J., Hinterkörner G., Hesse F., Galosy S., Mott J.E., Borth N. 2007

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Characterisation of cell behaviour by flow cytometry.

  Autoren: Borth N., Hinterkörner G., Hesse F., Ezzenje K., Matej M., Kunert R., Katinger H.,

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Characterisation of cell behaviour by flow cytometry.

  Autoren: Borth N., Hinterkörner G., Hesse F., Ezzenje K., Matej M., Kunert R., Katinger H.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Correlation between mitochondria-related fluorescent dyes and the energy metabolism in CHO cells

  Autoren: Hinterkörner G., Pichler J., Hesse F., Kunert R., Katinger H., Borth N.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Characterisation of cell behaviour by flow cytometry.

  Autoren: Borth N., Hinterkörner G., Hesse F., Ezzenje K., Matej M., Kunert R., Katinger H.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Correlation between mitochondria-related fluorescent dyes and the energy metabolism in CHO cells.

  Autoren: Hinterkörner G., Pichler J., Hesse F., Kunert R., Katinger H., Borth N.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Correlation between mitochondria-related fluorescent dyes and the energy metabolism in CHO cells

  Autoren: Hinterkörner G., Pichler J., Hesse F., Kunert R., Katinger H., Borth N.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Flow Cytometry and Cell Sorting in Cell Line Development.

  Autoren: Borth N., Hinterkörner G., Voglauer R., Hesse H., Matej M., Katinger H.

  Event: 1st SBE's Conference on Accelerating Biopharmaceutical Development 2007

• Year: 2007 -  Analysis of transient Antibod< Epxression in CHO cells.

  Autoren: Pichler J., Hinterkörner G., Hesse F., Galosy S., Mott J.E., Borth N.

  Event: 20th ESACT Meeting 2007

• Year: 2007 -  Flow Cytometry and Cell Sorting in Cell Line Development

  Autoren: Borth, N.; Hinterkörner, G.; Voglauer, R.; Hesse, F.; Matej, M.; Katinger, H.

  Event: Accelerating biopharmaceutical Production.

• Year: 2006 -  Use of flow cytometric cell sorting to obtain complex functional properties in biopharmaceutical production cell lines.

  Autoren: Borth Nicole

  Event: BBB Seminars: The BioMedical and BioSciences Lecture Series, University of Bergen

• Year: 2006 -  Cell Line Development by Fluorescence Activated Cell Sorting

  Autoren: Borth N., Brugger G., Hinterkörner G., Ernst W., Müller D., Hesse F., Kunert R., Katinger H.

  Event: Engineering Foundation Cell Culture Engineering X

• Year: 2006 -  Improvement of the Glycolytic metabolism im mammalian cells by fluorescence activated cell sorting

  Autoren: Borth Nicole

  Event: Cell Line Development and Engineering 2006

• Year: 2006 -  Biphasic cultivation - A simple strategy to improve the space-time yield of CHO based bioprocesses without affecting product quality

  Autoren: Müller, D.

  Event: Post Translational Modifications

• Year: 2006 -  Improvement of lactic acid production in yeast by cell sorting

  Autoren: Minoska Valli, Michael Sauer, Paola Branduardi, Nicole Borth, Danilo Porro, and Diethard Mattanovich

  Event: Annual Meeting of the ÖGBM, ÖGGGT, ÖGBT & ANGT - Life Science 2006

• Year: 2006 -  Improvement of the Energy Metabolism in Mammalian Cells by Fluorescence Activated Cell Sorting

  Autoren: Borth N.

  Event: Cell Line Development and Engineering 2006

• Year: 2006 -  Improvement of lactic acid production in yeast by cell sorting

  Autoren: Valli M., Sauer M., Branduardi P., Borth N., Porro D., Mattanovich D.

  Event: Life Sciences Austria Vienna Region: Life Science Circles: Industrielle Biotechnologie

• Year: 2005 -  From Gene to antibody: efficient screening by cell sorting.

  Autoren: Ernst Böhm, Johannes Grillari, Martina Löschel, Stefan Gross, Regina Voglauer, Renate Kunert, Hermann Katinger, Nicole Borth

  Event: 60 Year Anniversary, Institute of Applied Microbiology IAM 2005

• Year: 2005 -  Improvement of the glycolytic metabolism in mammalian cells by fluorescence activated cell sorting

  Autoren: Gudrun Brugger, Dethardt Müller, Renate Kunert, Friedemann Hesse, Hermann Katinger, Nicole Borth

  Event: 60 Year Anniversary, Institute of Applied Microbiology IAM 2005

• Year: 2005 -  Multiple flow cytometry analysis as a tool for the study of microbial fermentations

  Autoren: Maurer M., Gasser B., Benakovitsch K., Borth N., Mattanovich D.

  Event: Biotech 2005

• Year: 2005 -  FACS based isolation of high producing CHO cells with optimised process performance using a surface capture approach.

  Autoren: Borth N.

  Event: Bioprocess International 2005

• Year: 2005 -  From gene to monoclonal antibody: efficient screening by cell sorting

  Autoren: Borth N., Böhm E., Grillari J., Löscher M., Gross S., Voglauer R., Ferko B., Kunert R., Katinger H.

  Event: Animal Cell Technology meets Genomics

• Year: 2005 -  Sorting for high producers: Methods and application

  Autoren: Ernst Böhm, Max Zeyda, Willibald Steinfellner, Regina Voglauer, Renate Kunert, Hermann Katinger, Nicole Borth

  Event: 60 Year Anniversary, Institute of Applied Microbiology IAM 2005

• Year: 2005 -  High throughput methods for strain improvement - Flow Cytometry & FACS

  Autoren: Maurer M., Gasser B., Benakovitsch K., Valli M., Borth N., Mattanovich D.

  Event: 60 Year Anniversary, Institute of Applied Microbiology IAM 2005

• Year: 2005 -  Multiple flow cytometry analysis as a tool for the study of microbial fermentations

  Autoren: Maurer M., Gasser B., Benakovitsch K., Borth N. Mattanovich D.

  Event: 3rd International EFB Conference 2005 - Analysis of Microbial Cells at the Single Cell Level

• Year: 2005 -  Effect of pH, DO and Temperature on the Performance of CHO Cells in a Batch Process (Poster)

  Autoren: Trummer, E., Hesse, F., Seidinger, S., Fauland, K., Schriebl, K., Lattenmayer, C., Borth, N., Kunert, R., Vorauer-Uhl, K., Katinger, H., Müller, D.,

  Event: 19th ESACT Meeting 2005 - Cell Technology for Cell Products

• Year: 2005 -  Improvement of lactic acid production in yeast by cell sorting for high intracellular pH

  Autoren: Valli M., Sauer M., Borth N., Branduardi P., Porro D., Mattanovich D.

  Event: 60 Year Anniversary, Institute of Applied Microbiology IAM 2005

• Year: 2005 -  Improvement of the glycolytic metabolism in mammalian cells by fluorescence activated cell sorting

  Autoren: Borth N., Brugger G., Müller D., Hesse D., Kunert R., Katinger H.

  Event: 19th ESACT Meeting 2005 - Cell Technology for Cell Products

• Year: 2005 -  Serum-free Sorting of High Producing Recombinant CHO Cells (oral presentation)

  Autoren: Müller, D.; Borth, N.

  Event: 3rd International EFB Conference 2005 - Analysis of Microbial Cells at the Single Cell Level

• Year: 2005 -  Intracellular pH distribution in Saccharomyces cerevisiae cell populations analyzed by flow cytometry

  Autoren: Valli M., Sauer M., Branduardi P., Borth N., Porro D., Mattanovich D.

  Event: 3rd International EFB Conference 2005 - Analysis of Microbial Cells at the Single Cell Level

• Year: 2004 -  Effect of increased levels of Protein Disulfide Isomerase and BiP/GRP78 on human antibody productivity in recombinant CHO cells

  Autoren: Borth N, Mattanovich D., Kunert R, Katinger H.

  Event: Cell Culture Engineering IX, Engineering Foundation Conference

• Year: 2004 -  Analysis of energy metabolism in recombinant CHO cells by flow cytometric methods

  Autoren: Borth N., Brugger G., Müller D., Hesse F., Kunert R., Katinger H.

  Event: 3rd Recombinant Protein Production Meeting 2004

• Year: 2004 -  Effects of gene dosage, promoters and substrates on unfolded protein stress of recombinant Pichia pastoris

  Autoren: Gasser B., Hohenblum H., Maurer M., Borth N., Mattanovich D.

  Event: EFB Section Meeting “Physiology of Yeasts and Filamentous Fungi II”

• Year: 2004 -  Investigation of an important physiological parameter in yeast cells: the intracellular pH.

  Autoren: Valli M., Borth N., Sauer M., Branduardi P., Porro D., Mattanovich D.

  Event: EFB Section Meeting “Physiology of Yeasts and Filamentous Fungi II”

• Year: 2004 -  Comparison of protein profiles of different CHO cell lines

  Autoren: Przewalla, C., Chang, M., Kunert, R., Hesse, F., Grillari, J., Borth, N., Katinger, H.

  Event: 6th Siena meeting from genome to proteome 2004 - Biomarker discovery and proteome imaging

• Year: 2004 -  Genetic determination of recombinant protein expression clones under serum free cultivation conditions

  Autoren: Lattenmayer C., Löschel M., Borth N., Kunert R., Katinger H.

  Event: 3rd Recombinant Protein Production Meeting 2004

• Year: 2003 -  Efficient Selection of Antigen Specific Hybridomas by Cell Sorting using a Single Cell Secretion Assay

  Autoren: Borth N., Böhm E., Grillari J., Voglauer R., Kunert R., Gross S., Ferko B., Katinger H.

  Event: 18th ESACT Meeting 2003 - Animal Cell Technology Meets Genomics

• Year: 2003 -  Effiziente Selektion von hochproduzierenden tierischen Zelllinien für die Produktion von biopharmazeutischen Produkten mit dem Zellsorter

  Autoren: Borth N., Böhm E., Voglauer R., Kunert R., Katinger H.

  Event: Jahrestagung der Österreichischen Geselschaft für Flow Zytometrie

• Year: 2003 -  Control of Key Parameters in the Development of mammalian production clones

  Autoren: Kunert R., Preis S., Steinfellner W., Assadian A., Borth N., Müller D., Katinger H.

  Event: 18th ESACT Meeting 2003 - Animal Cell Technology Meets Genomics

• Year: 2003 -  From gene to monoclonal antibody: efficient screening by cell sorting

  Autoren: Borth, N., Böhm, E., Grillari, J., Löscher, M., Gross, S., Voglauer, R., Ferko, B., Kunert, R., Katinger, H.

  Event: 18th ESACT Meeting 2003 - Animal Cell Technology Meets Genomics

• Year: 2002 -  Control of key parameters in the development of mammalian production clones

  Autoren: R. Kunert, S. Wolbank, D. Müller, R. Voglauer, N. Borth, H. Katinger

  Event: Unknown

• Year: 2002 -  Screening for Additional Cell Properties: Selection of Subclones with Altered Production Kinetics or Improved Stability by Cell Sorting using an Affinity Matrix Secretion Assay

  Autoren: Borth, N., Böhm, E., Voglauer, R., Steinfellner, W., Kunert, R., Katinger, H.

  Event: UEF Cell Culture Engineering Conference

• Year: 2002 -  Flow Cytometric methods for sorting of high producing bacterial, yeast and animal cells

  Autoren: Borth N.

  Event: Analysis of Microbial Cells at the Single Cell Level 2002

• Year: 2002 -  Expression von Glykoproteinen in rekombinanten CHO-Zellen

  Autoren: R. Kunert, D. Müller, N. Borth, R. Weik, H. Katinger

  Event: Österreichische Gesellschaft für Zellkultur und European Tissue Culture Society: Neues aus der Zell- und Gewebekultur

• Year: 2002 -  Antibody secreting cell lines as model systems for affinity matrix secretion assay based cell sorting.

  Autoren: Böhm, E., Voglauer, R., Kunert, R., Grillari, J., Gross, S., Ferko, B., Katinger, H., Borth, N.

  Event: 15th Heidelberg Cytometry Symposium (HCS) Annual Meeting of the German Society of Cytometry (DGfZ)

• Year: 2002 -  Efficient selection of monoclonal, antigen-specific and high-producing hybridoma cell lines by flow cytometry and cell sorting: in a single cloning step ?

  Autoren: Böhm, E., Borth, N., Voglauer, R., Kunert, R., Ferko, B., Wiederkum, S., Stiegler, G., Hahn, R., Katinger, H.

  Event: ISAC 2002 XXI Congress of the International Society for Analytical Cytology

• Year: 2002 -  Efficient Selection of monoclonal, antigen-specific and high-producing Hybridoma Cell Lines in a Single Cloning Step by Flow Cytometry and Cell Sorting.

  Autoren: Böhm, E., Borth, N., Voglauer, R., Stiegler, G., Hahn, R., Ferko, B., Kunert, R., Katinger, H.

  Event: UEF Cell Culture Engineering Conference

• Year: 2001 -  Die Entwicklung klinischer Biopharmaka mittels nativer und rekombinanter Eukaryonten

  Autoren: Kunert,R., Vorauer-Uhl,K., Borth,N., Katinger,H.

  Event: Hochschullehrer-Nachwuchstreffen der DECHEMA

• Year: 2001 -  Efficient and Rapid Clone Selection of Human-Antibody Producing Xenohybridomas by Flow Cytometry and Cell Sorting According to Single Cell Specific Production Rate.

  Autoren: Böhm, E., Borth, N., Voglauer, R., Wiederkum, S., Kunert, R., Katinger, H.

  Event: Human Antibodies and Hybridomas 2001

• Year: 2001 -  Efficient and Rapid Clone selection of Human-antibody producing Xenohybridomas by flow cytometry and cell sorting according to single cell specific production rate

  Autoren: Borth N.

  Event: Human Antibodies and Hybridomas 2001

• Year: 2000 -  Establishment of recombinant CHO for industrial protein production

  Autoren: R.Kunert, K.Strutzenberger, F.Steindl, G.Vecera, A.Zudjelovic, N.Borth, H.Katinger

  Event: Recombinant Protein Production with prokaryotic and eukaryotic cells 2000 - A comparative view on host physiology

• Year: 2000 -  Maintenance of a high antibody expression level in CHO cells without selective and amplification pressure by cell sorting

  Autoren: Böhm, E., Borth, N., Voglauer, R., Kunert, R., Steinfellner, W., Katinger, H.

  Event: ISAC congress XX

• Year: 2000 -  Maintenance of a high antibody expression level in recombinant CHO cells without selective and amplification pressure by cell sorting.

  Autoren: Borth, N., Böhm, E., Voglauer, R., Kunert, R., Steinfellner, W., Katinger, H.

  Event: Recombinant Protein Production with prokaryotic and eukaryotic cells 2000 - A comparative view on host physiology

• Year: 2000 -  Determination of liposome size distribution by flow cytometry (Poster)

  Autoren: Vorauer-Uhl,K., Wagner,A., Borth,N., Voglauer,R., Katinger,H.

  Event: ISAC congress XX

• Year: 2000 -  Analysis of oncogene expression and chromosomal stability of SV40 early region transfected (ISAC congress XX,

  Autoren: Voglauer, R., Kunert, R., Hohenwarter, O., Böhm, E., Borth, N., Katinger, H.

  Event: ISAC congress XX

• 2000. Engineering of stress adapted protein expression systems in Escherichia coli by flow cytometry assisted library screening.

  Autoren: Soriano, E., Borth, N., Mattanovich, D., Katinger, H.

• Optimisation of the protein expression level in Escherichia coli by Flow Cytometry and Cell Sorting.

  Autoren: Soriano, E., Mattanovich, D., Borth, N., Katinger, H.

• Simultaneous flow cytometric analysis of intracellular product, total protein and DNA in recombinant Escherichia coli.

  Autoren: Soriano, E., Eywo, S., Borth, N., Mattanovich, D.

• Simultaneous analysis of intracellular product, total protein and DNA in recombinant Escherichia coli producing human superoxide dismutase.

  Autoren: Soriano, E., Eywo, S., Mitterbauer, R., Katinger, H., Mattanovich, D., Borth, N.

• Development of a stress-responsive expression system for Escherichia coli.

  Autoren: Eywo, S., Borth, N., Mattanovich, D.