Theresa Scharl-Hirsch
Dipl.-Ing.Dr. Theresa Scharl-Hirsch
Institute of Statistics
Location Peter-Jordan-Straße 82, 1190 Wien
Email theresa.scharl@boku.ac.at
Tel: +43 1 47654-85117
Data science Statistics Technical mathematics Bioinformatics
Research Focus
Machine Learning
Career
- 2024 Deputy Scientific Head (Core Facility Bioinformatics, University of Natural Resources and Life Sciences, Vienna (BOKU))
- 2020 Senior Scientist, Institute of Statistics, University of Natural Resources and Life Sciences Vienna
- 2009 - 2019 Senior Scientist, Austrian Center of Industrial Biotechnology
- 2004 - 2009 PhD Studies Applied Mathematics, Vienna University of Technology
- 2004 - 2009 Research Associate, Institute of Statistics and Probability Theory, Vienna University of Technology
- 2004 - 2020 Research Associate, Institute of Bioprocess Science and Engineering and Institute of Statistics, University of Natural Ressources and Life Sciences, Vienna
- 1998 - 2004 Studies in Applied Mathematics, Vienna University of Technology
Projects
0 Projects found.
Publications
Knowledge Transfer to Society
Media
Presentations
52 lecures found.
Year: 2025 - Clustering ordinal data within the flex-scheme
Art: Vortrag - Keynote Speaker (eingeladener Vortrag)
Autoren: Scharl, T
Event: 7th Joint Statistical Meeting of the Deutsche Arbeitsgemeinschaft Statistik (DAGStat) 2025
Period: 24.03.2025 - 28.03.2025 | Location: Unter den Linden 6, 10117 Berlin, Deutschland | Location: Unter den Linden 6, 10117 Berlin, Deutschland | Organizer: Humboldt-Universität zu Berlin
Year: 2024 - A Clustering Procedure for Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl, T; Grün, B
Event: Conference of the International Federation of Classification Societies 2024
Period: 15.07.2024 - 19.07.2024 | Location: Costa Rica | Location: 10103 San José, Costa Rica | Organizer: International Federation of Classification Societies | Organizer: Universität von Costa Rica
Year: 2024 - Visualizing and assessing model-based clustering solutions
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl, T; Grün, B
Event: Statistiktage 2024 der Österreichischen Statistischen Gesellschaft
Period: 03.04.2024 - 05.04.2024 | Location: Technische Universität Wien, AUSTRIA | Organizer: Österreichische Statistische Gesellschaft
Year: 2024 - Real-time Monitoring of a Protein A Capture A Step using Statistical Models
Art: Vortrag - Keynote Speaker (eingeladener Vortrag)
Autoren: Scharl, T
Event: European Summit of Industrial Biotechnology 2024
Period: 12.11.2024 - 14.11.2024 | Location: Graz, Österreich | Location: Graz, Österreich | Organizer: Austrian Center of Biopharmaceutical Technology | Organizer: ACIB GmbH
Year: 2024 - Monitoring of Bioprocesses using Explainable Machine Learning
Art: Poster - Ausgewählte Präsentation
Autoren: Scharl, T; Medl, M, Dürauer, A
Event: 14th European Symposium on Biochemical Engineering Sciences 2024
Period: 21.10.2024 - 23.10.2024 | Location: 1357 Kopenhagen, Dänemark | Location: 1357 Kopenhagen, Dänemark | Location: 1357 Kopenhagen, Dänemark | Organizer: Technical University of Denmark
Year: 2023 - Uncovering the black-box of data-driven models in biotechnological process modeling
Art: Vortrag - Ausgewählte Präsentation
Autoren: Medl, M; Scharl, T; Leisch, F; Dürauer, A
Event: 42nd International Symposium on the Separation of Proteins, Peptides and Polynucleotides 2023
Period: 05.11.2023 - 08.11.2023 | Location: Vienna, Austria | Location: Vienna, AUSTRIA | Location: Wien
Year: 2023 - A clustering procedure for 3-way RNA-seq data
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl-Hirsch, T.; Grün, B.
Event: JSM 2023
Period: 05.08.2023 - 10.08.2023 | Location: Toronto, Kanada
Year: 2023 - Efficient identification of optimal process conditions with Gaussian processes
Art: Vortrag - Ausgewählte Präsentation
Autoren: Medl, M; Winter, M; Erdem, I; Dürauer, A; Scharl, T
Event: 42nd International Symposium on the Separation of Proteins, Peptides and Polynucleotides 2023
Period: 05.11.2023 - 08.11.2023 | Location: Vienna, Austria | Location: Vienna, AUSTRIA | Location: Wien
Year: 2023 - Statistical Models in Up- and Downstream processing: their merits, limitations and realization with R
Art: Vortrag - Keynote Speaker (eingeladener Vortrag)
Autoren: Scharl, T
Event: HTPD, 2023
Period: 12.04.2023 - 14.04.2023 | Location: Vienna, Austria
Year: 2023 - Application of CNN ensembles to model Fourier transform infrared spectra
Art: Vortrag - Ausgewählte Präsentation
Autoren: Medl, M; Scharl, T; Leisch, F
Event: STATISTICAL COMPUTING 2023
Period: 30.07.2023 - 02.08.2023 | Location: GÜNZBURG
Year: 2022 - Deep learning to predict critical process parameters of an antibody capture process
Art: Vortrag - Ausgewählte Präsentation
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
Event: 14th Annual Meeting ÖGMBT 2022 - Life Sciences - now more than ever
Period: 19.09.2022 - 22.09.2022 | Location: Vienna, Austria
Year: 2022 - Modeling Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl, T.; Grün, B
Event: Austrian and Slovenian Statistical Days 2022
Period: 20.04.2022 - 22.04.2022 | Location: Graz, Austria
Year: 2022 - Modeling Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl, T; Grün, B.
Event: 17th Conference of the International Federation of Classification Societies IFCS 2022 - Classification and Data Science in the Digital Age
Period: 19.07.2022 - 23.07.2022 | Location: Porto, Portugal
Year: 2022 - Permutation based variable importance determination for deep learning
Art: Vortrag - Ausgewählte Präsentation
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
Event: 24th International Conference on Computational Statistics COMPSTAT 2022
Period: 23.08.2022 - 26.08.2022 | Location: Bologna, Italy
Year: 2022 - Deep Learning for Modelling High-dimensional Data of a Biopharmaceutical Purification Process
Art: Vortrag - Ausgewählte Präsentation
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
Event: Austrian and Slovenian Statistical Days 2022
Period: 20.04.2022 - 22.04.2022 | Location: Graz, Austria
Year: 2022 - Time Resolved Feature Importance of a Biopharmaceutical Purification Process Using Permutation Based Methods
Art: Vortrag - Ausgewählte Präsentation
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
Event: 17th Conference of the International Federation of Classification Societies IFCS 2022 - Classification and Data Science in the Digital Age
Period: 19.07.2022 - 23.07.2022 | Location: Porto, Portugal
Year: 2022 - Modeling three-Way RNA sequencing data using matrix-variate Gaussian mixture models
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl, T; Grün, B
Event: 24th International Conference on Computational Statistics COMPSTAT 2022
Period: 23.08.2022 - 26.08.2022 | Location: Bologna, Italy
Year: 2021 - Modeling Three-Way RNA Sequencing Data with Mixtures of Multivariate Poisson-Lognormal Distributions
Art: Vortrag - Ausgewählte Präsentation
Autoren: Theresa Scharl and Bettina Grün
Event: 13th Scientific Meeting of the Classification and Data Analysis Group CLADAG 2021
Period: 09.09.2021 - 11.09.2021 | Location: Online
Year: 2021 - Real-Time Monitoring and model-based Prediction of Product Purity and Quantity throughout Downstream Processing of Biopharmaceuticals
Art: Vortrag - Keynote Speaker (eingeladener Vortrag)
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
Event: PREP symposium 2021
Period: 07.06.2021 - 09.06.2021 | Location: Online
Year: 2019 - Hybrid semi-parametric modeling of preparative protein chromatography for online monitoring and real-time process-control
Art: Poster - Ausgewählte Präsentation
Autoren: Christler, A; von Stosch, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A
Event: European Congress of Applied Biotechnology ECAB5 2019
Period: 15.09.2019 - 19.09.2019 | Location: Florence, Italy
Year: 2019 - Handling large data for the prediction of quality attributes of an antibody capture process in real-time
Art: Poster - Ausgewählte Präsentation
Autoren: Scharl-Hirsch, T; Melcher, M; Felföldi, E; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F
Event: European Summit of Industrial Biotechnology ESIB 2019
Period: 18.11.2019 - 20.11.2019 | Location: Graz, Austria | Location: Graz, Austria
Year: 2019 - Modeling the Protein Quantity and Purity in Downstream Processing using Methods of Statistical Learning
Art: Poster - Ausgewählte Präsentation
Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Felfäldi, E; Christler, A; Jungbauer, A; Dürauer, K; Leisch, F
Event: European Summit of Industrial Biotechnology ESIB 2019
Period: 18.11.2019 - 20.11.2019 | Location: Graz, Austria | Location: Graz, Austria
Year: 2019 - Real-time prediction of protein quantity and purity in downstream processing
Art: Vortrag - Ausgewählte Präsentation
Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Felföldi, E; Christler, A; Jungbauer, A; Dürauer, A; Leisch, F
Event: European Congress of Applied Biotechnology ECAB5 2019
Period: 15.09.2019 - 19.09.2019 | Location: Florence, Italy
Year: 2019 - Using large data for the prediction of quality attributes of an antibody capture process in real-time
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl-Hirsch, T; Melcher, M; Felföldi, E; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F
Event: European Congress of Applied Biotechnology ECAB5 2019
Period: 15.09.2019 - 19.09.2019 | Location: Florence, Italy
Year: 2019 - Real-Time Monitoring and model-based Prediction of Purity and Quantity during chromatographic Purification of Biopharmaceuticals
Art: Vortrag - Ausgewählte Präsentation
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
Event: Biopartitioning & Purification Conference 2019
Period: 11.11.2019 - 13.11.2019 | Location: Guaruja, Brazil | Organizer: Brazilian Society of Microbiology
Year: 2019 - Real-Time Monitoring and model-based Prediction of Purity and Quantity during chromatographic Purification of Biopharmaceuticals
Art: Vortrag - Ausgewählte Präsentation
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
Event: Asian Pacific Confederation of Chemical Engineering APCChE 2019
Period: 23.09.2019 - 27.09.2019 | Location: Sapporo, Japan | Organizer: Japanese Society of Chemical Engineering
Year: 2018 - Machine Learning in Bioprocess Modeling
Art: Vortrag - Ausgewählte Präsentation
Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, DG; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F
Event: Data Science, Statistics & Visualisation DSSV 2018
Period: 09.07.2018 - 11.07.2018 | Location: Vienna, Austria
Year: 2018 - Model Based Real Time Monitoring in Chromatography
Art: Poster - Ausgewählte Präsentation
Autoren: Sauer, D; Walch, N; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Event: Recovery of Biological Products 2018
Period: 07.10.2018 - 12.10.2018 | Location: Asheville, NC, USA
Year: 2018 - Handling of large data in protein chromatography
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F;
Event: 12th European Symposium on Biochemical Engineering Sciences ESBES 2018
Period: 09.09.2018 - 12.09.2018 | Location: Lisbon, Portugal
Year: 2018 - Handling of large data in a protein purification process
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F;
Event: Data Science, Statistics & Visualisation DSSV 2018
Period: 09.07.2018 - 11.07.2018 | Location: Vienna, Austria
Year: 2018 - Real-time prediction of quantity, purity and impurities during antibody capture
Art: Vortrag - Ausgewählte Präsentation
Autoren: Walch, N; Sauer, D; Felföldi, E; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Event: SBCN 2018
Period: 14.05.2018 - 17.05.2018 | Location: Bordeaux, France
Year: 2018 - Online Monitoring of quantity, purity, and potency of an antibody capture process
Art: Vortrag - Ausgewählte Präsentation
Autoren: Walch, N; Sauer, D; Felföldi, E; Dürauer, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A
Event: 255th National Spring Meeting of the American Chemical Society ACS 2018 - Nexus of Food, Energy, and Water
Period: 18.03.2018 - 22.03.2018 | Location: New Orleans, LA, USA
Year: 2017 - Real-time monitoring of quantity and purity of fibroblast growth factor-2 during the chromatographic capture step
Art: Vortrag - Ausgewählte Präsentation
Autoren: Sauer, D; Walch, N; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Event: International Symposium on Preparative and Process Chromatography PREP 2017
Period: 16.07.2017 - 19.07.2017 | Location: Philadelphia, PA, USA
Year: 2017 - Real-time monitoring of purity, quantity and potency of fibroblast growth factor-2 during chromatographic capture and polishing steps
Art: Vortrag - Ausgewählte Präsentation
Autoren: Sauer, D., Walch, N., Scharl-Hirsch, T., Melcher, M., Leisch, F., Jungbauer, A., Dürauer, A.
Event: ECAB 2017
Period: 01.10.2017 - 05.10.2017 | Location: Barcelona, Spain
Year: 2017 - Online Monitoring of Quantity, Purity and Potency of an Antibody Capture Process
Art: Poster - Ausgewählte Präsentation
Autoren: Walch, N; Sauer, DG; Felföldi, E; Mosor, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Event: International Symposium and Exhibit on the Separation of Proteins, Peptides and Polynucleotides (ISPPP) 2017
Period: 19.07.2017 - 21.07.2017 | Location: Philadelphia, PA, USA
Year: 2017 - Prediction of fibroblast growth factor-2 protein's qualities in a downstream process: shrinkage regression and variable selection
Art: Poster - Ausgewählte Präsentation
Autoren: Tumolva, O; Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F
Event: European Summit of Industrial Biotechnology ESIB 2017
Period: 14.11.2017 - 16.11.2017 | Location: Graz, Austria
Year: 2017 - Real-time monitoring of quality attributes during a chromatographic capture step using statistical models
Art: Poster - Ausgewählte Präsentation
Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F
Event: European Summit of Industrial Biotechnology ESIB 2017
Period: 14.11.2017 - 16.11.2017 | Location: Graz, Austria
Year: 2017 - Online monitoring of quantity, purity and potency of an antibody capture process
Art: Vortrag - Ausgewählte Präsentation
Autoren: Walch, N., Sauer, D., Felföldi, E., Scharl-Hirsch, T., Melcher, M., Leisch, F., Jungbauer, A., Dürauer, A.
Event: ISPPP 2017
Period: 19.07.2017 - 21.07.2017 | Location: Philadelphia, PA, USA
Year: 2017 - Online Monitoring of Quantity, Purity and Potency of an Antibody Capture Process
Art: Poster - Ausgewählte Präsentation
Autoren: Walch, N; Sauer, D; Felföldi, E; Mosor, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Event: European Summit of Industrial Biotechnology ESIB 2017
Period: 14.11.2017 - 16.11.2017 | Location: Graz, Austria
Year: 2017 - Real-time Prediction of Potency, Purity and Concentration throughout a Chromatographic Capture Step of Basic Fibroblast Growth Factor 2
Art: Poster - Ausgewählte Präsentation
Autoren: Sauer, DG; Walch, N; Felföldi, E; Mosor, M; Frank, AC; Scharl-Hirsch, T; Melcher, M; Leisch, A; Jungbauer, A; Dürauer, A
Event: International Symposium and Exhibit on the Separation of Proteins, Peptides and Polynucleotides (ISPPP) 2017
Period: 19.07.2017 - 21.07.2017 | Location: Philadelphia, PA, USA
Year: 2017 - Real-time Prediction of Potency, Purity and Concentration throughout a Chromatographic Capture Step of Basic Fibroblast Growth Factor 2
Art: Poster - Ausgewählte Präsentation
Autoren: Sauer, D; Walch, N; Felföldi, E; Mosor, M; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Event: European Summit of Industrial Biotechnology ESIB 2017
Period: 14.11.2017 - 16.11.2017 | Location: Graz, Austria
Year: 2016 - Statistical evaluation of performance parameters of prepacked columns over a time span of ten years
Art: Poster - Ausgewählte Präsentation
Autoren: Scharl, T; Schweiger, S; Jungreuthmayer, C; Dürauer, A; Schröder, T; Jungbauer, A
Event: 29th International Symposium on Preparative and Process Chromatography PRREP 2016
Period: 17.07.2016 - 20.07.2016 | Location: Philadelphia, PA, USA
Year: 2016 - Real-time monitoring of quantity, purity and potency of biopharmaceuticals in purification processes
Art: Poster - Ausgewählte Präsentation
Autoren: Sauer, D; Walch, N; Felföldi, E; Mayer-Maschl, S; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer,A; Jungbauer, A
Event: ESIB – European Summit of Industrial Biotechnology
Period: 14.11.2016 - 16.11.2016 | Location: Graz, Austria
Year: 2016 - Real-time monitoring of quantity, purity and potency of biopharmaceuticals in purification processes
Art: Poster - Ausgewählte Präsentation
Autoren: Walch, N; Sauer, D; Felföldi, E; Mayer-Maschl, S; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A
Event: European Summit of Industrial Biotechnology ESIB 2016
Period: 14.11.2016 - 16.11.2016 | Location: Graz, Austria | Organizer: Austrian Centre of Industrial Biotechnology
Year: 2016 - Prediction of key parameters in the production of biopharmaceuticals using R
Art: Vortrag - Ausgewählte Präsentation
Autoren: Scharl, T; Melcher, M; Striedner, G; Leisch, F
Event: UseR! 2016
Period: 27.06.2016 - 30.06.2016 | Location: Stanford, CA, USA
Year: 2016 - Real-time monitoring of purification processes – vision or reality?
Art: Vortrag - Ausgewählte Präsentation
Autoren: Sauer, D.,Walch, N., Felföldi, E., Mayer-Maschl, S., Scharl-Hirsch, T.,Melcher, M., Leisch, F., Dürauer, A., Jungbauer, A.
Event: Evon Up 2 Date
Period: 22.06.2016 | Location: Stubenberg, Austria
Year: 2015 - Statistical Modeling in Bioprocess Monitoring
Art: Poster - Ausgewählte Präsentation
Autoren: Melcher, M; Scharl, T; Luchner, M; Striedner, G; Leisch, F
Event: Statistiktage 2015
Period: 21.10.2015 - 23.10.2015 | Location: Vienna, Austria
Year: 2013 - Online Prediction of Biomass and Product Yield for Recombinant Protein Production in Escherichia Coli Expression Systems
Art: Poster - Ausgewählte Präsentation
Autoren: Melcher, M; Scharl, T; Spangl, B; Luchner, M; Cserjan, M; Striedner, G; Leisch, F
Event: ACIB Science Days 2013
Period: 10.09.2013 - 12.09.2013 | Location: Graz, Austria
Year: 2011 - Host cell response to recombinant gene expression in E. coli based expression systems
Art: Vortrag - Ausgewählte Präsentation
Autoren: Striedner G., Bayer K., Cserjan M., Mairhofer J., Scharl T., Marisch K., Luchner M.: , International Workshop on Biological Products and Bioprocesses, Varadero, Cuba, 26.06.2011 - 30.06.2011
Event: International Workshop on Biological Products and Bioprocesses 2011
Period: 26.06.2011 - 30.06.2011 | Location: Varadero, Cuba
Year: 2010 - Analysis of transcriptome and proteome - Escherichia coli cultivation data
Art: Vortrag - Ausgewählte Präsentation
Autoren: Marisch, K; Scharl, T; Strobl, F; Auer, N; Krempl, P; Hummel, K; Razzazi-Fazeli, E; Bayer, K; Striedner, G
Event: 2nd ÖGMBT Annual Meeting 2010
Period: 27.09.2010 - 29.09.2010 | Location: Vienna, Austria | Organizer: ÖGMBT (Österreichische Gesellschaft für Molekulare Biowissenschaften und Biotechnologie)
Year: 2009 - Application of transcriptome and proteome analysis for comparative evaluation of industrial E. coli production strains
Art: Poster - Ausgewählte Präsentation
Autoren: Karoline Marisch, Norbert Auer, Monika Cserjan, Markus Luchner, Ebrahim Razzazi-Fazeli, Theresa Scharl, Florian Strobl, Gerald Striedner and Karl Bayer
Event: International Conference on Systems Biology 2009
Period: 29.08.2009 - 04.09.2009 | Location: Stanford, CA, USA
Year: 2008 - Monitoring of industrial E. coli strains (K12 and BL21) during batch - cultivations using transcriptome and proteome techniques
Art: Vortrag - Ausgewählte Präsentation
Autoren: Karoline Marisch, Gerald Striedner, Theresa Scharl, Florian Strobl, Norbert Auer, Karin Hummel, Ebrahim Razzazi-Fazeli and Karl Bayer
Event: 5th Conference on Recombinant Protein Production 2008
Period: 24.09.2008 - 28.09.2008 | Location: Porto Conte, Italy