Vera Pfanzagl
Dipl.-Ing. Vera Pfanzagl Ph.D.
Institute of Biochemistry
Location Muthgasse 18, 1190 Wien
Email vera.pfanzagl@boku.ac.at
Tel: +43 1 47654-77279
ORCID: 0000-0002-9361-8365, opens in new window.
AuthorId : 57200222267
ResearcherId : AAE-9025-2019
Research Focus
We study the structure-function relationship of human heme peroxidases using a combination of biochemical analysis, X-ray crystallography and molecular biology. Currently we focus on three proteins, Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) from the innate immune response and Thyroid peroxidas (TPO), the main enzyme catalyzing thyroid hormone production. We want to unravel the fine differences between MPO and EPO to understand their divergent function and to find exploitable structural traits for design of new selective inhibitors. The membrane bound TPO on the other hand, is not only essential for hormone biosynthesis but also a main auto-antigen in Hashimotos disease, where constant attack by auto-antibodies leads to a degradation of the thyroid gland. Here we focus on solving the crystal structure and understanding the properties of TPO in detail to understand the high prevalence of TPO associated autoimmune diseases.
Career
- 2024 Elise-Richter Fellow (Department of Chemistry, BOKU)
- 2019 - 2024 Post-Doc (Department of Chemistry, BOKU)
- 2015 - 2019 Dissertation withing the international PhD programme BioToP at the Department of Chemistry, BOKU
- 2015 Technician at the Department for Applied Genetics and Cell Biology, BOKU
- 2014 FEMtech internship at the Department for Applied Genetics and Cell Biology, BOKU
- 2011 master thesis at the NIBR Novartis, Switzerland
- 2011 - 2014 Master Biotechnology (BOKU)
- 2007 - 2011 Bachelor Food- and Biotechnology (BOKU)
Projects
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Publications
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Knowledge Transfer to Society
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Presentations
Year: 2024 - Myeloperoxidase dimerization in solution is mediated by interface glycans (Poster)
Autoren: Leitgeb, U; Furtmüller, PG; Obinger, C; Pfanzagl, V
Event: 34th European Crystallographic Meeting 2024
Period: 26.08.2024 - 30.08.2024 | Location: Padua, Italien | Organizer:
European Crystallographic AssociationYear: 2023 - Reactivity and protein-protein interaction of human peroxidasin 1 (Talk)
Autoren: Furtmüller, PG, Paumann-Page, M; Pfanzagl, V; Hofbauer, S; Obinger, C
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer:
Semmelweis EgyetemYear: 2023 - Reconstitution and linkage of heme in thyroid peroxidase post-purification (Poster)
Autoren: Parzer, B; Furtmüller, PG; Obinger, C; Pfanzagl, V
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer:
Semmelweis EgyetemYear: 2023 - First crystal structure of eosinophil peroxidase reveals suptile distinctions in the active site architecture and processing (Talk)
Autoren: Pfanzagl, V; Leitgeb, U; Grünwald-Gruber, C; Furtmüller, PG; Obinger, C
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer:
Semmelweis EgyetemYear: 2023 - The inhibitory protein SPIN reduces the halide oxidation rate of myeloperoxidase but leaves the substrate binding site unaffected (Talk)
Autoren: Leitgeb, U; Brito, JA; Furtmüller, PG; Obinger, C; Pfanzagl, V
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer:
Semmelweis EgyetemYear: 2023 - Testing the incorporation efficiency of phenylalanine derivatives with dual fluorescent reporter proteins (Poster)
Autoren: Terzer, F; Leitgeb, U; Marin, Z; Kani, A.A; Wiltschi, B; Pfanzagl, V; Obinger, C
Event: 12th International Human Peroxidase Meeting 2023
Period: 30.08.2023 - 02.09.2023 | Location: Budapest, Hungary | Location: Budapest, Ungarn | Organizer:
Semmelweis EgyetemYear: 2022 - Biochemistry of Enzymes Involved in the Coproporphyrin-Dependent Heme Biosynthesis Pathway of Gram-Positive Bacteria (Talk)
Autoren: Hofbauer, S; Gabler, T; Patil, G; Michlits, H; Pfanzagl, V; Obinger, C; Furtmüller, PG
Event: Gordon Research Conference - Chemistry and Biology of Tetrapyrroles
Period: 17.07.2022 - 22.07.2022 | Location: Newport, Rhode Island, USA
Year: 2022 - Structural and mechanistic insights in dimeric chlorite dismutase - Impact of pH and the dynamics of the catalytic arginine (Talk)
Autoren: Schmidt, D; Serra, I; Hofbauer, S; Pfanzagl, V; Van Doorslaer, S; Obinger, C; Furtmüller, P.G.
Event: 16th European Biological Inorganic Chemistry 2022
Period: 17.07.2022 - 21.07.2022 | Location: Grenoble, France
Year: 2022 - New insights into B-class dye-decolorizing peroxidases: tracing radical sites with electron paramagnetic resonance (Talk)
Autoren: Van Doorslaer, S; Nys, K; Furtmüller, PG; Obinger, C; Pfanzagl, V;
Event: 12th International Conference on Porphyrins and Phtalocyanines ICPP-12 2022
Period: 10.07.2022 - 15.07.2022 | Location: Madrid, Spain
Year: 2022 - Reactivity of peroxidases and chlorite dismutases with chlorite and hypochlorite: a spectroscopic investigation of short-lived intermediates trapped by fast freeze-quenching (Talk)
Autoren: Serra, I; Schmidt, D; Hofbauer, S; Pfanzagl, V; García-Rubio, I; Furtmüller, PG; Obinger C; and Van Doorslaer, V;
Event: The 55th Annual International Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry 2022
Period: 06.06.2022 - 10.06.2022 | Location: St. Andrews, Scotland, UK
Year: 2022 - X-ray induced reduction of heme metal centers is protein-independent (Talk)
Autoren: Pfanzagl, V; Beale, JH; Michlits, H; Schmidt, D; Gabler, T; Obinger, C; Djinovic-Carugo, K; Hofbauer, S;
Event: 33rd European Crystallographic Meeting
Period: 23.08.2022 - 27.08.2022 | Location: Versailles, France
Year: 2021 - Coproporphyrin ferrochelatase – study of relevant residues for substrate and product binding (Talk)
Autoren: Gabler, T; Pfanzagl, V; Obinger, C; Furtmüller PG; Hofbauer, S
Event: International Conference on Porphyrins and Phthalocyanines - ICPP11
Period: 28.06.2021 - 03.07.2021 | Location: Online
Year: 2019 - X-ray induced redcution kinetics of heme metal centers is protein-independent (Poster)
Autoren: Pfanzagl, V; Beale, J; Schmidt, D; Michlits, H; Gabler, T; Djinovic-Carugo, K; Obinger, C; Hofbauer, S
Event: 11th Human Peroxidase Meeting
Period: 04.09.2019 - 07.09.2019 | Location: Brno, Czech Republic
Year: 2019 - Posttranslational Modification of Heme in Peroxidases - Impact on Structure and Function (Talk)
Autoren: Furtmüller, PG; Nicolussi, A; Sevcnikar, B; Paumann-Page, M; Auer, M; Zamocky, M; Pfanzagl, V; Hofbauer, S; Obinger, C
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2019 - An actinobacterial representative sheds a new light on the reaction mechanism of coproheme decarboxylases (Poster)
Autoren: Michlits, H; Pfanzagl, V; Furtmüller, PG; Djinovic-Carugo, K; Obinger, C; Hofbauer, S
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2019 - YfeX - A new player involved in the redox gated potassium efflux pump KefC (Poster)
Autoren: Pfanzagl, V; Schwaiger, L; Michlits, H; Hofbauer, S; Obinger, C
Event: Gordon Research Conference: Mechanisms of Membrane Transport
Period: 23.06.2019 - 28.06.2019 | Location: New London, UK
Year: 2019 - X-ray induced redcution kinetics of heme metal centers is protein-independent - implications for structural studies of redox sensitive proteins (Poster)
Autoren: Pfanzagl, V; Beale, J; Schmidt, D; Michlits, H; Gabler, T; Djinovic-Carugo, K; Obinger, C; Hofbauer, S
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2019 - X-ray induced reduction of heme metal centers is protein-independent – implications for structural studies of redox sensitive proteins (Talk)
Autoren: Pfanzagl, V; Beale, JH; Schmidt, D; Michlits, H; Gabler, T; Djinovic-Carugo, C; Obinger, C; Hofbauer, S
Event: Hot Topics in Crystallography 4
Period: 01.10.2019 - 06.10.2019 | Location: Dubrovnik, Croatia
Year: 2019 - Molecular mechanism of coproheme to heme b conversion (Talk)
Autoren: Hofbauer, S; Milazzo, L; Gabler, T; Pühringer, D; Pfanzagl, V; Djinovic-Carugo, K; Furtmüller, PG; Obinger, C; Smulevich, G
Event: 19th International Conference on Biological Inorganic Chemistry 2019
Period: 11.08.2019 - 16.08.2019 | Location: Interlaken, Switzerland
Year: 2018 - Kinetic and spectroscopic characterization of EfeB (Poster)
Autoren: Michlits, H., Pfanzagl, V., Schwaiger, L., Furtmüller, P. G., Hofbauer, S., Obinger, C.
Event: OxiZymes 2018
Period: 08.07.2018 - 10.07.2018 | Location: Belfast, Northern Ireland, UK
Year: 2018 - Posttranslational Modification of Heme in Peroxidases – Impact on Structure and Catalysis (Talk)
Autoren: Furtmüller, PG; Nicolussi, A; Auer, M; Paumann-Page, M; Sevcnikar, B; Pfanzagl, V; Zámocký, M; Hofbauer, S; Obinger, C;
Event: Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
Period: 01.07.2018 - 06.07.2018 | Location: Munich, Germany
Year: 2018 - Pulsed EPR analysis of dye-decolorizing peroxidases and chlorite dismutases (Talk)
Autoren: Van Doorslaer, S., Nys, K., Pfanzagl, V., Obinger, C., De Schutter, S., González P.J.
Event: EMBO workshop “Challenges for magnetic resonance in life sciences"
Period: 27.05.2018 - 01.06.2018 | Location: Grosseto, Italy
Year: 2018 - Mechanistic Studies on Coproheme Decarboxylase (Poster)
Autoren: Hofbauer, S; Milazzo, L; Mlynek, G; Gabler, T; Howes, BD; Pfanzagl, V; Djinović-Carugo, K; Furtmüller, PG; Smulevich, G; Obinger, C
Event: Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
Period: 01.07.2018 - 06.07.2018 | Location: Munich, Germany
Year: 2018 - New insights into the B-class dye-decolorizing peroxidases: An EPR study of the heme and radical sites in a DyP from K. pneumoniae (Poster)
Autoren: Nys, K., Pfanzagl, V., Mlynek, G., Djinovic-Carugo, K., Obinger, C., Van Doorslaer, S.
Event: 51st meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry
Period: 08.04.2018 - 12.04.2018 | Location: London, UK
Year: 2018 - Crystal and Electronic Structure of Compound I in Dye-decolorizing Peroxidases (Talk)
Autoren: Pfanzagl, V; Hofbauer, S; Beale, J; Mlynek, G; Michlits, H; Nys, K; Van Doorslaer, S; Djinovic-Carugo, K; Furtmüller, PG; Obinger, C
Event: Tenth International Conference on Porphyrins and Phthalocyanines (ICPP-10)
Period: 01.07.2018 - 06.07.2018 | Location: Munich, Germany
Year: 2018 - On Compound I formation in B-type dye decolorizing peroxidases - lessons from structural and kinetic studies. (Talk)
Autoren: Pfanzagl, V., Nys, K., Mlynek, G., Djinović-Carugo, K., Van Doorslaer, S., Furtmüller, P. G., Hofbauer, S., Obinger, C.
Event: OxiZymes 2018
Period: 08.07.2018 - 10.07.2018 | Location: Belfast, Northern Ireland, UK
Year: 2018 - Coproheme decarboxylases – phylogenetic prediction versus biochemical analysis. (Talk)
Autoren: Pfanzagl, V., Holcik, L., Maresch, D., Michlits, H., Furtmüller, P. G., Obinger, C., Hofbauer, S.
Event: OxiZymes 2018
Period: 08.07.2018 - 10.07.2018 | Location: Belfast, Northern Ireland, UK
Year: 2017 - Roles of the distal Asp-Arg pair in Compound I formation of K. pneumoniae dye-decolorizing peroxidase (Talk)
Autoren: Pfanzagl, V; Hofbauer, S; Nys, K; Djinovic-Carugo, K; Battistuzzi, G; Van Doorslaer, S; Furtmuller, PG; Obinger, C
Event: International Conference on Bioinorganic Chemistry ICBIC-18 2017
Period: 31.07.2017 - 04.08.2017 | Location: Florianopolis, Brazil
Year: 2017 - Roles of the distal Asp-Arg pair in compound I formation of K. pneumoniae dye-decolorizing peroxidase (Poster)
Autoren: Pfanzagl, V; Hofbauer, S; Nys, K; Djinović-Carugo, K; Battistuzzi, G; Van Doorslaer, S; Furtmüller, P.G; and Obinger, C;
Event: International Conference on Bioinorganic Chemistry ICBIC-18 2017
Period: 31.07.2017 - 04.08.2017 | Location: Florianopolis, Brazil
Year: 2016 - Dye decolorizing peroxidases - A new heme-peroxidase family with ancient roots (Talk)
Autoren: Pfanzagl, V; Schaffner, I; Hofbauer, S; Furtmuller, P; Obinger, C
Event: European Congress on Biotechnology 2016
Period: 03.07.2016 - 06.07.2016 | Location: Krakow, Poland | Organizer:
European Federation of BiotechnologyYear: 2016 - Dye decolorizing peroxidases – a new heme-peroxidase family with ancient roots (Talk)
Autoren: Pfanzagl, V; Schaffner, I; Hofbauer, S; Furtmüller, P.G; Obinger, C
Event: 17th European Congress on Biotechnology ECB17 2016
Period: 03.07.2016 - 06.07.2016 | Location: Krakow, Poland
Year: 2016 - Dye-decolorizing peroxidases – a new heme-peroxidase family with ancient roots (Poster)
Autoren: Pfanzagl, V., Furtmüller, P. G., Obinger, C. 2016. Dye-decolorizing peroxidases – a new heme-peroxidase family with ancient roots
Event: 13th European Biological Inorganic Chemistry Conference EuroBIC 2016
Period: 28.08.2016 - 01.09.2016 | Location: Budapest, Hungary
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