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Suchbegriffe: Chinese hamster ovary, 1970. Treffer: 48

** = Publikationen gelistet in SCI/SSCI (veröffentlicht im Web of Science)
* = Publikationen in sonstigen peer-reviewten Journalen (ggf. noch nicht im WoS veröffentlicht)
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** Marx, N; Eisenhut, P; Weinguny, M; Klanert, G; Borth, N; How to train your cell - Towards controlling phenotypes by harnessing the epigenome of Chinese hamster ovary production cell lines..

Biotechnol Adv. 2022; 56:107924 WoS PubMed FullText FullText_BOKU


** Bayer, B; Duerkop, M; Striedner, G; Sissolak, B; Model Transferability and Reduced Experimental Burden in Cell Culture Process Development Facilitated by Hybrid Modeling and Intensified Design of Experiments..

Front Bioeng Biotechnol. 2021; 9:740215 WoS PubMed PUBMED Central FullText FullText_BOKU

** Helgers, H; Schmidt, A; Lohmann, LJ; Vetter, FL; Juckers, A; Jensch, C; Mouellef, M; Zobel-Roos, S; Strube, J Towards Autonomous Operation by Advanced Process Control-Process Analytical Technology for Continuous Biologics Antibody Manufacturing.

PROCESSES. 2021; 9(1), 172 WoS FullText FullText_BOKU

** Muralidharan-Chari, V; Wurz, Z; Doyle, F; Henry, M; Diendorfer, A; Tenenbaum, SA; Borth, N; Eveleth, E; Sharfstein, ST PTSelect (TM): A post-transcriptional technology that enables rapid establishment of stable CHO cell lines and surveillance of clonal variation.

J BIOTECHNOL. 2021; 325: 360-371. WoS PubMed FullText FullText_BOKU

** Széliová, D; Iurashev, D; Ruckerbauer, DE; Koellensperger, G; Borth, N; Melcher, M; Zanghellini, J; Error propagation in constraint-based modeling of Chinese hamster ovary cells..

Biotechnol J. 2021; 16(4):e2000320 WoS PubMed FullText FullText_BOKU

** Weinguny, M; Klanert, G; Eisenhut, P; Lee, I; Timp, W; Borth, N Subcloning induces changes in the DNA-methylation pattern of outgrowing Chinese hamster ovary cell colonies.

BIOTECHNOL J. 2021; 16(6), e2000350 WoS PubMed FullText FullText_BOKU


** Dhiman, H; Campbell, M; Melcher, M; Smith, KD; Borth, N; Predicting favorable landing pads for targeted integrations in Chinese hamster ovary cell lines by learning stability characteristics from random transgene integrations..

Comput Struct Biotechnol J. 2020; 18:3632-3648 WoS PubMed PUBMED Central FullText FullText_BOKU

** Hamdi, A; Szeliova, D; Ruckerbauer, DE; Rocha, I; Borth, N; Zanghellini, J Key Challenges in Designing CHO Chassis Platforms.

PROCESSES. 2020; 8(6), 643 WoS FullText FullText_BOKU

** Nguyen, LN; Novak, N; Baumann, M; Koehn, J; Borth, N; Bioinformatic Identification of Chinese Hamster Ovary (CHO) Cold-Shock Genes and Biological Evidence of their Cold-Inducible Promoters..

Biotechnol J. 2020; 15(3):e1900359 WoS PubMed FullText FullText_BOKU

** Szeliova, D; Ruckerbauer, DE; Galleguillos, SN; Petersen, LB; Natter, K; Hanscho, M; Troyer, C; Causon, T; Schoeny, H; Christensen, HB; Lee, DY; Lewis, NE; Koellensperger, G; Hann, S; Nielsen, LK; Borth, N; Zanghellini, J What CHO is made of: Variations in the biomass composition of Chinese hamster ovary cell lines.

METAB ENG. 2020; 61: 288-300. WoS PubMed FullText FullText_BOKU

** Weinguny, M; Klanert, G; Eisenhut, P; Jonsson, A; Ivansson, D; Lovgren, A; Borth, N Directed evolution approach to enhance efficiency and speed of outgrowth during single cell subcloning of Chinese Hamster Ovary cells.

COMPUT STRUCT BIOTEC. 2020; 18: 1320-1329. WoS PubMed FullText FullText_BOKU


** Amann, T; Schmieder, V; Kildegaard, HF; Borth, N; Andersen, MR Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms.

BIOTECHNOL BIOENG. 2019; 116(10): 2778-2796. WoS PubMed FullText FullText_BOKU

** Dhiman, H; Gerstl, MP; Ruckerbauer, D; Hanscho, M; Himmelbauer, H; Clarke, C; Barron, N; Zanghellini, J; Borth, N; Genetic and Epigenetic Variation across Genes Involved in Energy Metabolism and Mitochondria of Chinese Hamster Ovary Cell Lines..

Biotechnol J. 2019; 14(7):e1800681 WoS PubMed FullText FullText_BOKU

** Hernandez, I; Dhiman, H; Klanert, G; Jadhav, V; Auer, N; Hanscho, M; Baumann, M; Esteve-Codina, A; Dabad, M; Gómez, J; Alioto, T; Merkel, A; Raineri, E; Heath, S; Rico, D; Borth, N; Epigenetic regulation of gene expression in Chinese Hamster Ovary cells in response to the changing environment of a batch culture..

Biotechnol Bioeng. 2019; 116(3):677-692 WoS PubMed PUBMED Central FullText FullText_BOKU

** Nguyen, LN; Baumann, M; Dhiman, H; Marx, N; Schmieder, V; Hussein, M; Eisenhut, P; Hernandez, I; Koehn, J; Borth, N Novel Promoters Derived from Chinese Hamster Ovary Cells via In Silico and In Vitro Analysis.

BIOTECHNOL J. 2019; 14(11), 1900125 WoS PubMed FullText FullText_BOKU

** Reinhart, D; Damjanovic, L; Kaisermayer, C; Sommeregger, W; Gili, A; Gasselhuber, B; Castan, A; Mayrhofer, P; Grünwald-Gruber, C; Kunert, R; Bioprocessing of Recombinant CHO-K1, CHO-DG44, and CHO-S: CHO Expression Hosts Favor Either mAb Production or Biomass Synthesis..

Biotechnol J. 2019; 14(3):e1700686 WoS PubMed FullText FullText_BOKU


** Nagelreiter, F; Coats, MT; Klanert, G; Gludovacz, E; Borth, N; Grillari, J; Schosserer, M; OPP Labeling Enables Total Protein Synthesis Quantification in CHO Production Cell Lines at the Single-Cell Level..

Biotechnol J. 2018; 13(4):e1700492 WoS PubMed FullText FullText_BOKU

** Reinhart, D; Damjanovic, L; Castan, A; Ernst, W; Kunert, R Differential gene expression of a feed-spiked super-producing CHO cell line.

J BIOTECHNOL. 2018; 285: 23-37. WoS PubMed FullText FullText_BOKU


** Baumann, M; Gludovacz, E; Sealover, N; Bahr, S; George, H; Lin, N; Kayser, K; Borth, N Preselection of recombinant gene integration sites enabling high transcription rates in CHO cells using alternate start codons and recombinase mediated cassette exchange.

BIOTECHNOL BIOENG. 2017; 114(11): 2616-2627. WoS PubMed FullText FullText_BOKU

** Hennicke, J; Lastin, AM; Reinhart, D; Grünwald-Gruber, C; Altmann, F; Kunert, R; Glycan profile of CHO derived IgM purified by highly efficient single step affinity chromatography..

Anal Biochem. 2017; 539:162-166 WoS PubMed FullText FullText_BOKU

** Kelly, PS; Clarke, C; Costello, A; Monger, C; Meiller, J; Dhiman, H; Borth, N; Betenbaugh, MJ; Clynes, M; Barron, N Ultra-deep next generation mitochondrial genome sequencing reveals widespread heteroplasmy in Chinese hamster ovary cells.

METAB ENG. 2017; 41: 11-22. WoS PubMed FullText FullText_BOKU

** Prats Mateu, B; Harreither, E; Schosserer, M; Puxbaum, V; Gludovacz, E; Borth, N; Gierlinger, N; Grillari, J; Label-free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines..

Biotechnol J. 2017; 12(1): WoS PubMed PUBMED Central FullText FullText_BOKU

** Shridhar, S; Klanert, G; Auer, N; Hernandez-Lopez, I; Kandula, MM; Hackl, M; Grillari, J; Stralis-Pavese, N; Kreil, DP; Borth, N Transcriptomic changes in CHO cells after adaptation to suspension growth in protein-free medium analysed by a species-specific microarray.

J BIOTECHNOL. 2017; 257: 13-21. WoS PubMed FullText FullText_BOKU


** Feichtinger, J; Hernandez, I; Fischer, C; Hanscho, M; Auer, N; Hackl, M; Jadhav, V; Baumann, M; Krempl, PM; Schmidl, C; Farlik, M; Schuster, M; Merkel, A; Sommer, A; Heath, S; Rico, D; Bock, C; Thallinger, GG; Borth, N Comprehensive Genome and Epigenome Characterization of CHO Cells in Response to Evolutionary Pressures and Over Time.

BIOTECHNOL BIOENG. 2016; 113(10): 2241-2253. WoS PubMed FullText FullText_BOKU

** Gludovacz, E; Maresch, D; Bonta, M; Szollosi, H; Furtmuller, PG; Weik, R; Altmann, F; Limbeck, A; Borth, N; Jilma, B; Boehm, T Characterization of recombinant human diamine oxidase (rhDAO) produced in Chinese Hamster Ovary (CHO) cells.

J BIOTECHNOL. 2016; 227: 120-130. WoS FullText FullText_BOKU

** Kaisermayer, C; Reinhart, D; Gili, A; Chang, M; Aberg, PM; Castan, A; Kunert, R Biphasic cultivation strategy to avoid Epo-Fc aggregation and optimize protein expression.

J BIOTECHNOL. 2016; 227: 3-9. WoS PubMed FullText FullText_BOKU

** Kunert, R; Reinhart, D Advances in recombinant antibody manufacturing.

APPL MICROBIOL BIOT. 2016; 100(8): 3451-3461. WoS PubMed PUBMED Central FullText FullText_BOKU

** Sommeregger, W; Mayrhofer, P; Steinfellner, W; Reinhart, D; Henry, M; Clynes, M; Meleady, P; Kunert, R; Proteomic differences in recombinant CHO cells producing two similar antibody fragments..

Biotechnol Bioeng. 2016; 113(9):190-112 WoS PubMed PUBMED Central FullText FullText_BOKU


** Diendorfer, AB; Hackl, M; Klanert, G; Jadhav, V; Reithofer, M; Stiefel, F; Hesse, F; Grillari, J; Borth, N; Annotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data..

Biotechnol Bioeng. 2015; 112(7):1488-1493 WoS PubMed PUBMED Central FullText FullText_BOKU

** Harreither, E; Hackl, M; Pichler, J; Shridhar, S; Auer, N; Labaj, PP; Scheideler, M; Karbiener, M; Grillari, J; Kreil, DP; Borth, N Microarray profiling of preselected CHO host cell subclones identifies gene expression patterns associated with in-creased production capacity.

BIOTECHNOL J. 2015; 10(10): 1625-1638. WoS PubMed FullText FullText_BOKU

** Reinhart, D; Damjanovic, L; Kaisermayer, C; Kunert, R Benchmarking of commercially available CHO cell culture media for antibody production.

APPL MICROBIOL BIOT. 2015; 99(11): 4645-4657. WoS PubMed PUBMED Central FullText FullText_BOKU


** Hackl, M; Jadhav, V; Klanert, G; Karbiener, M; Scheideler, M; Grillari, J; Borth, N; Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation..

J Biotechnol. 2014; 190:76-84 WoS PubMed PUBMED Central FullText FullText_BOKU

** Jadhav, V; Hackl, M; Klanert, G; Bort, JAH; Kunert, R; Grillari, J; Borth, N Stable overexpression of miR-17 enhances recombinant protein production of CHO cells.

J BIOTECHNOL. 2014; 175: 38-44. WoS PubMed PUBMED Central FullText FullText_BOKU

** Maccani, A; Hackl, M; Leitner, C; Steinfellner, W; Graf, AB; Tatto, NE; Karbiener, M; Scheideler, M; Grillari, J; Mattanovich, D; Kunert, R; Borth, N; Grabherr, R; Ernst, W Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation.

APPL MICROBIOL BIOT. 2014; 98(17): 7535-7548. WoS PubMed PUBMED Central FullText FullText_BOKU

** Reinhart, D; Sommeregger, W; Debreczeny, M; Gludovacz, E; Kunert, R In search of expression bottlenecks in recombinant CHO cell lines-a case study..

Appl Microbiol Biotechnol. 2014; 98(13):5959-5965 WoS PubMed FullText FullText_BOKU


** Gerstl, MP; Hackl, M; Graf, AB; Borth, N; Grillari, J Prediction of transcribed PIWI-interacting RNAs from CHO RNAseq data.

J BIOTECHNOL. 2013; 166(1-2): 51-57. WoS PubMed FullText FullText_BOKU

** Jadhav, V; Hackl, M; Druz, A; Shridhar, S; Chung, CY; Heffner, KM; Kreil, DP; Betenbaugh, M; Shiloach, J; Barron, N; Grillari, J; Borth, N CHO microRNA engineering is growing up: Recent successes and future challenges.

BIOTECHNOL ADV. 2013; 31(8): 1501-1513. WoS PubMed PUBMED Central FullText FullText_BOKU

** Tscheliessnig, AL; Konrath, J; Bates, R; Jungbauer, A; Host cell protein analysis in therapeutic protein bioprocessing - methods and applications..

Biotechnol J. 2013; 8(6):655-670 WoS PubMed FullText FullText_BOKU


** Hackl, M; Jadhav, V; Jakobi, T; Rupp, O; Brinkrolf, K; Goesmann, A; Pühler, A; Noll, T; Borth, N; Grillari, J Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines..

J Biotechnol. 2012; 158(3):151-155 WoS PubMed PUBMED Central FullText FullText_BOKU

** Hammond, S; Kaplarevic, M; Borth, N; Betenbaugh, MJ; Lee, KH Chinese hamster genome database: An online resource for the CHO community at

Biotechnol Bioeng. 2012; 109(6):1353-1356 WoS PubMed FullText FullText_BOKU

** Jadhav, V; Hackl, M; Hernandez Bort, JA; Wieser, M; Harreither, E; Kunert, R; Borth, N; Grillari, J A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells..

Biotechnol Bioeng. 2012; 109(6):1376-1385 WoS PubMed FullText FullText_BOKU


** Becker, J; Hackl, M; Rupp, O; Jakobi, T; Schneider, J; Szczepanowski, R; Bekel, T; Borth, N; Goesmann, A; Grillari, J; Kaltschmidt, C; Noll, T; Pühler, A; Tauch, A; Brinkrolf, K Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing..

J Biotechnol. 2011; 156(3):227-235 WoS PubMed FullText FullText_BOKU

** Hackl, M; Jakobi, T; Blom, J; Doppmeier, D; Brinkrolf, K; Szczepanowski, R; Bernhart, SH; Siederdissen, CH; Bort, JA; Wieser, M; Kunert, R; Jeffs, S; Hofacker, IL; Goesmann, A; Pühler, A; Borth, N; Grillari, J Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering..

J Biotechnol. 2011; 153(1-2):62-75 WoS PubMed PUBMED Central FullText FullText_BOKU


** Pontiller, J; Maccani, A; Baumann, M; Klancnik, I; Ernst, W; Identification of CHO endogenous gene regulatory elements..

Mol Biotechnol. 2010; 45(3):235-240 WoS PubMed FullText FullText_BOKU


** Pontiller, J; Gross, S; Thaisuchat, H; Hesse, F; Ernst, W Identification of CHO endogenous promoter elements based on a genomic library approach.

MOL BIOTECHNOL. MOLECULAR BIOTECHNOLOGY; 39: 135-139. (ISBN: Sao Paulo, Brazil) WoS PubMed FullText FullText_BOKU


** Hinterkörner, G; Brugger, G; Müller, D; Hesse, F; Kunert, R; Katinger, H; Borth, N Improvement of the energy metabolism of recombinant CHO cells by cell sorting for reduced mitochondrial membrane potential..

J Biotechnol. 2007; 129(4):651-657 WoS PubMed FullText FullText_BOKU


** Borth, N; Zeyda, M; Kunert, R; Katinger, H; Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting..

Biotechnol Bioeng. 2001; 71(4):266-273 WoS PubMed


** Strutzenberger, K; Borth, N; Kunert, R; Steinfellner, W; Katinger, H Changes during subclone development and ageing of human antibody-producing recombinant CHO cells..

J Biotechnol. 1999; 69(2-3):215-226 WoS PubMed

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