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Gewählte Master / Diploma Thesis:

Peter Boesch (2007): Case Study of Monocional Antibody Production - Analysis and Facility Design.
Master / Diploma Thesis, BOKU-Universität für Bodenkultur, pp 95. UB BOKU obvsg

Data Source: ZID Abstracts
Abstract:
As the biopharmaceutical market matures, a thorough knowledge of the production plants with respect to engineering and economics are crucial issues for a competitive facility design. The object of this master thesis was to analyze several basic designs of production plants for monoclonal antibodies. To summarize the findings of this project an optimal facility for monoclonal antibodies should be built as flexible and adaptable as possible by minimizing the number of tanks within the facility by means of e.g. inline dilution or substitution with disposables. A major finding is that an increase of the host cell line's productivity leads to a significantly improved upstream area but doesn't affect the downstream. All these steps support the decrease of the utilities, which account for one-fourth to one-third of the equipment costs depending on the facility scale and type. Perfusion seems to have the greater potential when scaling up, but fed batch is still the safer option. One factor with major impact on the costs is the yearly output whereby an increase lowers the costs per dose decisively.

Beurteilende(r): Bayer Karl

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