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Gewählte Doctoral Thesis:

Nicole Pircher (2015): Tailoring of Cellulosic Aerogels for Biomedical Applications.
Doctoral Thesis - Abteilung für Chemie nachwachsender Rohstoffe, BOKU-Universität für Bodenkultur, pp 196. UB BOKU obvsg FullText

Data Source: ZID Abstracts
Abstract:
Cellulosic aerogels (CAG) are ultra-lightweight, open porous solids and promising materials for a range of applications, in particular in the biomedical sector. Based on the results of this work, CAG can now be tailored to be used as cell scaffolding materials for tissue engineering applications. It has been found that micro-morphological aerogel features, such as crystallinity, fibril diameter and fractal dimension, and therefore the bulk properties of CAG can be controlled by the choice of solvent/antisolvent system used to dissolve and coagulate cellulose. CAG derived from solutions of cellulose in Ca(SCN)2·8H2O melts proofed to be particularly promising with regard to solid structure and mechanical properties. It has been discovered that addition of LiCl allows dissolution of much higher amounts of cellulose in shorter time and at reduced temperature. The fragility of CAG is still a challenge regarding many applications. Methods for mechanical reinforcement of CAG with interpenetrating networks of biocompatible polymers have therefore been developed in this work. Deficient macroporosity inhibiting cell ingrowth and proliferation hitherto prevented CAG from broad use in tissue engineering. The current work established a novel approach to dual-porous CAG using temporary templates (packed beds of fused microspheres) to generate interconnected large micron-scale pores (≥ 100 µm) within the nanoporous CAG structure (≤ 10 µm). Preliminary tests using NIH 3T3 fibroblast cells revealed good biocompatibility. Surface oxidation of cellulose II aerogels yielded 2,3-dialdehyde cellulose (DAC) scaffolds, which are promising for bone tissue engineering, due to improved bioresorbability and biomineralization of DAC. Highly periodate-oxidized cellulose has been used to prepare novel transparent, flexible films of excellent oxygen barrier properties for packaging and biosensing applications.

Betreuer: Liebner Falk
1. Berater: Rosenau Thomas

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