University of Natural Resources and Life Sciences, Vienna (BOKU) - Research portal
Gewählte Doctoral Thesis:
Marivil Islam
(2013):
BEHAVIOUR OF VETERINARY DRUGS IN SOIL, PLANT AND WATER SYSTEM
Transport investigation of antiparasitic drugs in soil-plant-water.
Doctoral Thesis - Institut für Bodenforschung (IBF),
BOKU-Universität für Bodenkultur,
pp 89.
UB BOKU
obvsg
FullText
- Abstract:
- The use of anthelmintics in food producing animals could affect the ecological system due to the application of manure containing drugs to the land. Translocation of antiparasitic drugs from animal excrement through soil and water to crops and forages and their recycling to food (crops and grazing animals) is also a potential concern for the food chain. To investigate the behaviour of some drugs in soil, plant and water, a lysimeter experiment was designed. Slurry containing three representative anthelmintics, levamisole (LEV), fenbendazole (FBZ), and eprinomectin (EPR), was applied to lysimeters containing sandy or loamy soil and samples of alfalfa and water were collected at different time intervals, and soil samples at different intervals and depths. The samples were analysed for the target analytes and the sulphoxide (FBZ-SO) and sulphone (FBZ-SO2) metabolites of fenbendazole using a previously validated LC-MS/MS method. Results showed that in the upper horizon (0-10 cm) of soils the target analytes and metabolites of FBZ were found at high concentrations even at the final sampling time (day 290). In the lower horizon (10-30 cm), all target compounds were detected on day 10 and both FBZ-SO and FBZ-SO2 were found even at day 290 only in loamy soil. The concentration of FBZ-SO was higher at soil depth 10-20 cm and the FBZ-SO2 at 20-30 cm. In seepage water LEV (0.8 µg l-1) was the only compound detected (day-36). In plants the maximum concentration of EPR (40.2 µg kg-1) was found in sandy soil at day 32, LEV (37.0 µg kg-1) at day 32 in loamy soil and FBZ-SO metabolite (19 µg kg-1) at day 63 in loamy soil, at approximately 4 times the concentration of FBZ or FBZ-SO2. A radiotracer experiment using 14C-LEV showed that LEV and its transformation products were transported into the lower horizon.
- Betreuer: Gerzabek Martin
- 1. Berater: Haberhauer Georg