Elisabeth Laurent

Publications

26 Publications found.

• An engineering strategy to target activated EGFR with CAR T cells

  Source: Dobersberger M, Sumesgutner D, Zajc CU, Salzer B, Laurent E, Emminger D, et al. An engineering strategy to target activated EGFR with CAR T cells. Cell reports methods [Internet]. 2024;4(4):100728. doi:10.1016/j.crmeth.2024.100728

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• Strategy to increase tumor specificity of EGFR-Targeting Therapies

  Source: Dobersberger M, Laurent E, Sylvander E, Seigner J, Teufl M, Salzer B, et al. Strategy to increase tumor specificity of EGFR-Targeting Therapies. Human Gene Therapy. 2022;33(7-8):A17-A18.

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• Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level.

  Source: Zhu R, Canena D, Sikora M, Klausberger M, Seferovic H, Mehdipour A, et al. Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature Communications. 2022;13(1):7926. doi:https://doi.org/10.1038/s41467-022-35641-3

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• Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana.

  Source: Castilho A, Schwestka J, Kienzl N, Vavra U, Grünwald-Gruber C, Izadi S, et al. Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana. Biotechnology Journal. 2021;16(6):e2000566. doi:https://doi.org/10.1002/biot.202000566

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• Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients

  Source: Laurent E, Sieber A, Salzer B, Wachernig A, Seigner J, Lehner M, et al. Directed Evolution of Stabilized Monomeric CD19 for Monovalent CAR Interaction Studies and Monitoring of CAR-T Cell Patients. ACS Synthetic Biology [Internet]. 2021;10:1184-98. doi:10.1021/acssynbio.1c00010

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• Inefficient CAR-proximal signaling blunts antigen sensitivity

  Source: Gudipati V, Rydzek J, Perez I, Goncalves V, Scharf L, Konigsberger S, et al. Inefficient CAR-proximal signaling blunts antigen sensitivity. European Journal of Immunology. 2021;51:32-.

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• Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor.

  Source: Capraz T, Kienzl N, Laurent E, Perthold J, Föderl-Höbenreich E, Grünwald-Gruber C, et al. Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor. eLife. 2021;10. doi:https://doi.org/10.7554/eLife.73641

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• Impact of Specific

  Source: Schwestka J, König-Beihammer J, Shin Y, Vavra U, Kienzl N, Grünwald-Gruber C, et al. Impact of Specific . Frontiers in Plant Science. 2021;12:747500. doi:https://doi.org/10.3389/fpls.2021.747500

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• N-Glycosylation of the SARS-CoV-2 Receptor Binding Domain Is Important for Functional Expression in Plants

  Source: Shin Y, Konig-Beihammer J, Vavra U, Schwestka J, Kienzl N, Klausberger M, et al. N-Glycosylation of the SARS-CoV-2 Receptor Binding Domain Is Important for Functional Expression in Plants. Frontiers in Plant Science. 2021;12. doi:https://doi.org/10.3389/fpls.2021.689104

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• Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function

  Source: Salzer B, Schueller C, Zajc C, Peters T, Schoeber M, Kovacic B, et al. Engineering AvidCARs for combinatorial antigen recognition and reversible control of CAR function. Nature Communications. 2020;11(1). doi:https://doi.org/10.1038/s41467-020-17970-3

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• Inefficient CAR-proximal signaling blunts antigen sensitivity

  Source: Venugopal G, Julian R, Iago D-P, Vasco D, Lydia S, Sebastian K, et al. Inefficient CAR-proximal signaling blunts antigen sensitivity. Nature Immunology [Internet]. 2020;21:848-56. doi:10.1038/s41590-020-0719-0

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• Getting CD19 Into Shape: Expression of Natively Folded “Difficult-to- Express” CD19 for Staining and Stimulation of CAR-T Cells

  Source: Lobner E, Wachernig A, Gudipati V, Mayrhofer P, Salzer B, Lehner M, et al. Getting CD19 Into Shape: Expression of Natively Folded “Difficult-to- Express” CD19 for Staining and Stimulation of CAR-T Cells. Frontiers in Bioengineering and Biotechnology [Internet]. 2020;8:49. doi:10.3389/fbioe.2020.00049

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• AVIDCARS - A NOVEL PLATFORM FOR INTEGRATION OF MULTIPLE INPUT SIGNALS BY ONE CAR MOLECULE

  Source: Salzer B, Brey C, Schueller C, Schoeber M, Lobner E, Dushek O, et al. AVIDCARS - A NOVEL PLATFORM FOR INTEGRATION OF MULTIPLE INPUT SIGNALS BY ONE CAR MOLECULE. Human Gene Therapy. 2019;30(12):A4-A4.

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• Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies.

  Source: Lobner E, Humm A, Göritzer K, Mlynek G, Puchinger M, Hasenhindl C, et al. Fcab-HER2 Interaction: a Ménage à Trois. Lessons from X-Ray and Solution Studies. Structure. 2017;25(6):878-889.e5. doi:https://doi.org/10.1016/j.str.2017.04.014

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• Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex.

  Source: Lobner E, Humm A, Mlynek G, Kubinger K, Kitzmüller M, Traxlmayr M, et al. Two-faced Fcab prevents polymerization with VEGF and reveals thermodynamics and the 2.15 Å crystal structure of the complex. mAbs. 2017;9(7):1088-104. doi:https://doi.org/10.1080/19420862.2017.1364825

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• Engineered IgG1-Fc--one fragment to bind them all.

  Source: Lobner E, Traxlmayr M, Obinger C, Hasenhindl C. Engineered IgG1-Fc--one fragment to bind them all. Immunological Reviews. 2016;270(1):31-. doi:https://doi.org/10.1111/imr.12385

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• A hyperstable miniprotein as an alternative to antibodies

  Source: Traxlmayr M, Kiefer J, Srinivas R, Lobner E, Tisdale A, Mehta N, et al. A hyperstable miniprotein as an alternative to antibodies. In: ÖGMBT - Österreichische Gesellschaft für Molekulare Biowissenschaften und Biotechnologie , editor. Abstract Book 2016. 2016.

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• Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library

  Source: Traxlmayr M, Kiefer J, Srinivas R, Lobner E, Tisdale A, Mehta N, et al. Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library. Journal of Biological Chemistry. 2016;291(43):22496-508. doi:https://doi.org/10.1074/jbc.M116.741314

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• Structures and thermodynamics of Fcab-antigen complexes.

  Source: Lobner, E, Humm, A-S, Göritzer, K, et al. Structures and thermodynamics of Fcab-antigen complexes. In: CHI, Cambridge Innovation Institute , editor. PEGS 2016. 2016.

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• Recombinant production and structural characterization of Fcabs

  Source: Lobner, E, Humm, A-S, Göritzer, K, et al. Recombinant production and structural characterization of Fcabs. In: Ferrer P, Mattanovich D , editors. 8th Conference on Recombinant Protein Production; a comparative view on host physiology. 2015.

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