Shiva Izadi

Publications

12 Publications found.

• An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters

  Source: Föderl-Höbenreich E, Izadi S, Hofacker L, Kienzl N, Castilho A, Strasser R, et al. An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters. Scientific Reports. 2025;15(1):11307. doi:https://doi.org/10.1038/s41598-025-95494-w

  Journal articles

  external links and characteristics of the publication:

  

  

  

  

    

• Advancements in drug discovery: integrating CADD tools and drug repurposing for PD-1/PD-L1 axis inhibition.

  Source: Patrícia S, Tiago C, Shiva I, Alexandra C, Zélia S, Paula A, et al. Advancements in drug discovery: integrating CADD tools and drug repurposing for PD-1/PD-L1 axis inhibition. Rsc Advances. 2025;15(4):2298-316. doi:10.1039/d4ra08245a

  Journal articles

  external links and characteristics of the publication:

  

  

  

  

  

    

• Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding

  Source: Izadi S, Gumpelmair S, Coelho P, Duarte H, Gomes J, Leitner J, et al. Plant-derived Durvalumab variants show efficient PD-1/PD-L1 blockade and therapeutically favourable FcR binding. Plant Biotechnology Journal. 2024;22(5):1224-37. doi:https://doi.org/10.1111/pbi.14260

  Journal articles

  external links and characteristics of the publication:

  

  

  

  

  

  

    

• Improving the -glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297.

  Source: Göritzer K, Ruocco V, Vavra U, Izadi S, Bolaños-Martínez OC, Phetphoung T, et al. Improving the -glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297. Frontiers in Plant Science. 2024;15:1531710. doi:10.3389/fpls.2024.1531710

  Journal articles

  external links and characteristics of the publication:

  

  

  

  

  

    

• Assessment of transient expression strategies to sialylate recombinant proteins in N. benthamiana

  Source: Izadi S, Kunnummel V, Steinkellner H, Werner S, Castilho A. Assessment of transient expression strategies to sialylate recombinant proteins in N. benthamiana. Journal of Biotechnology. 2023;365:48-53. doi:https://doi.org/10.1016/j.jbiotec.2023.02.004

  Journal articles

  external links and characteristics of the publication:

  

  

• Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents

  Source: Battin C, Linhares ADS, Leitner J, Grossmann A, Lupinek D, Izadi S, et al. Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents. Cancer Immunology Immunotherapy [Internet]. 2023;72:3029-43. doi:10.1007/s00262-023-03474-8

  Journal articles

  external links and characteristics of the publication:

  

  

  

  

    

• In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc

  Source: Izadi S, Vavra U, Melnik S, Grünwald-Gruber C, Föderl-Höbenreich E, Sack M, et al. In planta deglycosylation improves the SARS-CoV-2 neutralization activity of recombinant ACE2-Fc. Frontiers in Bioengineering and Biotechnology [Internet]. 2023;11:1180044. doi:10.3389/fbioe.2023.1180044

  Journal articles

  external links and characteristics of the publication:

  

  

  

  

    

• The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation

  Source: Schoberer J, Izadi S, Kierein C, Vavra U, König-Beihammer J, Ruocco V, et al. The tobacco GNTI stem region harbors a strong motif for homomeric protein complex formation. Frontiers in Plant Science. 2023;14. doi:https://doi.org/10.3389/fpls.2023.1320051

  Journal articles

  external links and characteristics of the publication:

  

  

  

    

• The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif

  Source: Aigner-Radakovics K, Linhares A, Salzer B, Lehner M, Izadi S, Castilho A, et al. The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif. Science Signaling. 2023;16(805). doi:https://doi.org/10.1126/scisignal.adg2610

  Journal articles

  external links and characteristics of the publication:

  

  

• Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana.

  Source: Castilho A, Schwestka J, Kienzl N, Vavra U, Grünwald-Gruber C, Izadi S, et al. Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana. Biotechnology Journal. 2021;16(6):e2000566. doi:https://doi.org/10.1002/biot.202000566

  Journal articles

  external links and characteristics of the publication:

  

  

• The Instability of Dimeric Fc-Fusions Expressed in Plants Can Be Solved by Monomeric Fc Technology

  Source: Gattinger P, Izadi S, Grunwald-Gruber C, Kallolimath S, Castilho A. The Instability of Dimeric Fc-Fusions Expressed in Plants Can Be Solved by Monomeric Fc Technology. Frontiers in Plant Science. 2021;12. doi:https://doi.org/10.3389/fpls.2021.671728

  Journal articles

  external links and characteristics of the publication:

  

  

  

    

• Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo

  Source: Izadi S, Javaran M, Monfared S, Castilho A. Reteplase Fc-fusions produced in N. benthamiana are able to dissolve blood clots ex vivo. PLoS One. 2021;16(11). doi:https://doi.org/10.1371/journal.pone.0260796

  Journal articles

  external links and characteristics of the publication: