Theresa Scharl-Hirsch

Lectures

• Year: 2024 -  A Clustering Procedure for Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models

  Autoren: Scharl, T; Grün, B

  Event: Conference of the International Federation of Classification Societies 2024

• Year: 2024 -  Visualizing and assessing model-based clustering solutions

  Autoren: Scharl, T; Grün, B

  Event: Statistiktage

• Year: 2023 -  Uncovering the black-box of data-driven models in biotechnological process modeling

  Autoren: Matthias Medl, Theresa Scharl, Friedrich Leisch, Astrid Dürauer

  Event: 42nd International Symposium on the Separation of Proteins, Peptides and Polynucleotides 2023

• Year: 2023 -  A clustering procedure for 3-way RNA-seq data

  Autoren: Scharl-Hirsch, T.; Grün, B.

  Event: JSM 2023

• Year: 2023 -  Efficient identification of optimal process conditions with Gaussian processes

  Autoren: Medl, M; Winter, M; Erdem, I; Dürauer, A; Scharl, T;

  Event: 42nd International Symposium on the Separation of Proteins, Peptides and Polynucleotides (ISPPP)

• Year: 2023 -  Statistical Models in Up- and Downstream processing: their merits, limitations and realization with R

  Autoren: Theresa Scharl

  Event: HTPD, 2023

• Year: 2023 -  Application of CNN ensembles to model Fourier transform infrared spectra

  Autoren: Matthias Medl, Theresa Scharl, Friedrich Leisch

  Event: STATISTICAL COMPUTING 2023

• Year: 2022 -  Deep learning to predict critical process parameters of an antibody capture process

  Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch

  Event: 14th Annual Meeting ÖGMBT 2022 - Life Sciences - now more than ever

• Year: 2022 -  Modeling Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models

  Autoren: Scharl, T.; Grün, B

  Event: Austrian and Slovenian Statistical Days 2022

• Year: 2022 -  Modeling Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models

  Autoren: Scharl, T; Grün, B.

  Event: 17th Conference of the International Federation of Classification Societies IFCS 2022 - Classification and Data Science in the Digital Age

• Year: 2022 -  Permutation based variable importance determination for deep learning

  Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch

  Event: 24th International Conference on Computational Statistics COMPSTAT 2022

• Year: 2022 -  Deep Learning for Modelling High-dimensional Data of a Biopharmaceutical Purification Process

  Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch

  Event: Austrian and Slovenian Statistical Days 2022

• Year: 2022 -  Time Resolved Feature Importance of a Biopharmaceutical Purification Process Using Permutation Based Methods

  Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch

  Event: 17th Conference of the International Federation of Classification Societies IFCS 2022 - Classification and Data Science in the Digital Age

• Year: 2022 -  Modeling three-Way RNA sequencing data using matrix-variate Gaussian mixture models

  Autoren: Scharl, T; Grün, B

  Event: 24th International Conference on Computational Statistics COMPSTAT 2022

• Year: 2021 -  Modeling Three-Way RNA Sequencing Data with Mixtures of Multivariate Poisson-Lognormal Distributions

  Autoren: Theresa Scharl and Bettina Grün

  Event: 13th Scientific Meeting of the Classification and Data Analysis Group CLADAG 2021

• Year: 2021 -  Real-Time Monitoring and model-based Prediction of Product Purity and Quantity throughout Downstream Processing of Biopharmaceuticals

  Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A

  Event: PREP symposium 2021

• Year: 2019 -  Hybrid semi-parametric modeling of preparative protein chromatography for online monitoring and real-time process control

  Autoren: Christler, A; Felföldi, E; von Stosch, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Real-time monitoring and model-based prediction of purity and quantity in a chromatographic step of a biopharmaceutical

  Autoren: Sauer, D.; Melcher, M.; Walch, N.; Scharl-Hirsch, T.; Leisch, F.; Jungbauer, A.; Dürauer, A.

  Event: PREP Symposium 2019

• Year: 2019 -  Hybrid semi-parametric modeling of preparative protein chromatography for online monitoring and real-time process-control

  Autoren: Christler, A; von Stosch, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A

  Event: European Congress of Applied Biotechnology ECAB5 2019

• Year: 2019 -  Handling large data for the prediction of quality attributes of an antibody capture process in real-time

  Autoren: Scharl-Hirsch, T; Melcher, M; Felföldi, E; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Real-Time Monitoring and model-based Prediction of Purity and Quantity during chromatographic Purification of Biopharmaceuticals

  Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A

  Event: BPP 2019

• Year: 2019 -  Modeling the Protein Quantity and Purity in Downstream Processing using Methods of Statistical Learning

  Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Felfäldi, E; Christler, A; Jungbauer, A; Dürauer, K; Leisch, F

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Real-time prediction of protein quantity and purity in downstream processing

  Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Felföldi, E; Christler, A; Jungbauer, A; Dürauer, A; Leisch, F

  Event: European Congress of Applied Biotechnology ECAB5 2019

• Year: 2019 -  Real Time Monitoring and Model-Based Prediction of Purity and Quantity of Biopharmaceuticals

  Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A

  Event: European Summit of Industrial Biotechnology ESIB 2019

• Year: 2019 -  Real-Time Monitoring and model-based Prediction of Purity and Quantity during chromatographic Purification of Biopharmaceuticals

  Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A

  Event: APCChE 2019

• Year: 2019 -  Real-time monitoring and model-based prediction of purity and quantity during chromatographic purification of biopharmaceuticals

  Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A

  Event: Asian Pacific Confederation of Chemical Engineering (APCChE)

• Year: 2019 -  Real-time monitoring and model.based prediction of purity and quantity during chromatographic purification of biopharmaceuticals

  Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A

  Event: Biopartitioning & Purification Conference (BPP2019)

• Year: 2019 -  Using large data for the prediction of quality attributes of an antibody capture process in real-time

  Autoren: Scharl-Hirsch, T; Melcher, M; Felföldi, E; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F

  Event: European Congress of Applied Biotechnology ECAB5 2019

• Year: 2018 -  Online Monitoring of quantity, purity, and potency of an antibody capture process

  Autoren: Walch, N; Sauer, D; Felföldi, E; Dürauer, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A

  Event: 255th National Spring Meeting of the American Chemical Society ACS 2018 - Nexus of Food, Energy, and Water

• Year: 2018 -  Machine Learning in Bioprocess Modeling

  Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, DG; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F

  Event: Data Science, Statistics & Visualisation DSSV 2018

• Year: 2018 -  Real-Time Monitoring ofquantity, potency and purity of FGF-2 in a chromatographic capture process

  Autoren: Sauer, D; Walch, N; Melcher, M; Scharl-Hirsch, T;, P; Jungbauer, A; Dürauer A.

  Event: Bioproduction 2018

• Year: 2018 -  Model Based Real Time Monitoring in Chromatography

  Autoren: Sauer, D; Walch, N; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A

  Event: Recovery of Biological Products 2018

• Year: 2018 -  Online monitoring of quantity, purity and potency of an antibody capture process

  Autoren: Walch, N; Sauer, D; Felfoldi, E; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Durauer, A

  Event: 255th National Spring Meeting of the American Chemical Society ACS 2018 - Nexus of Food, Energy, and Water

• Year: 2018 -  Handling of large data in protein chromatography

  Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F;

  Event: 12th European Symposium on Biochemical Engineering Sciences ESBES 2018

• Year: 2018 -  Handling of large data in a protein purification process

  Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F;

  Event: Data Science, Statistics & Visualisation DSSV 2018

• Year: 2018 -  Real-Time Monitoring ofquantity, potency and purity of FGF-2 in a chromatographic capture process

  Autoren: Sauer, D; Walch, N; Melcher, M; Scharl-Hirsch, T;, P; Jungbauer, A; Dürauer A.

  Event: European Symposium On Biochemical Engineering Sciences 2018

• Year: 2018 -  Real-time prediction of quantity, purity and impurities during antibody capture

  Autoren: Walch, N; Sauer, D; Felföldi, E; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A

  Event: SBCN 2018

• Year: 2017 -  Real-time monitoring of quantity and purity of fibroblast growth factor-2 during the chromatographic capture step

  Autoren: Sauer, D; Walch, N; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A

  Event: International Symposium on Preparative and Process Chromatography PREP 2017

• Year: 2017 -  Real-time monitoring of purity, quantity and potency of fibroblast growth factor-2 during chromatographic capture and polishing steps

  Autoren: Sauer, D., Walch, N., Scharl-Hirsch, T., Melcher, M., Leisch, F., Jungbauer, A., Dürauer, A.

  Event: ECAB 2017

• Year: 2017 -  Online Monitoring of Quantity, Purity and Potency of an Antibody Capture Process

  Autoren: Walch, N; Sauer, DG; Felföldi, E; Mosor, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A

  Event: International Symposium and Exhibit on the Separation of Proteins, Peptides and Polynucleotides (ISPPP) 2017

• Year: 2017 -  Real-Time Monitoring of quantitiy and purity of firbroblast growth factor-2 during a chromatographic capture step

  Autoren: Sauer, D.; Walch, N.; Scharl-Hirsch, T.; Melcher, M.; Leisch, F.; Jungbauer, A.; Dürauer, A.

  Event: PREP Symposium 2017

• Year: 2017 -  Prediction of fibroblast growth factor-2 protein's qualities in a downstream process: shrinkage regression and variable selection

  Autoren: Tumolva, O; Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Real-time monitoring of quality attributes during a chromatographic capture step using statistical models

  Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Online monitoring of quantity, purity and potency of an antibody capture process

  Autoren: Walch, N., Sauer, D., Felföldi, E., Scharl-Hirsch, T., Melcher, M., Leisch, F., Jungbauer, A., Dürauer, A.

  Event: ISPPP 2017

• Year: 2017 -  Online Monitoring of Quantity, Purity and Potency of an Antibody Capture Process

  Autoren: Walch, N; Sauer, D; Felföldi, E; Mosor, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2017 -  Real-time Prediction of Potency, Purity and Concentration throughout a Chromatographic Capture Step of Basic Fibroblast Growth Factor 2

  Autoren: Sauer, DG; Walch, N; Felföldi, E; Mosor, M; Frank, AC; Scharl-Hirsch, T; Melcher, M; Leisch, A; Jungbauer, A; Dürauer, A

  Event: International Symposium and Exhibit on the Separation of Proteins, Peptides and Polynucleotides (ISPPP) 2017

• Year: 2017 -  Real-time Prediction of Potency, Purity and Concentration throughout a Chromatographic Capture Step of Basic Fibroblast Growth Factor 2

  Autoren: Sauer, D; Walch, N; Felföldi, E; Mosor, M; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A

  Event: European Summit of Industrial Biotechnology ESIB 2017

• Year: 2016 -  Statistical evaluation of performance parameters of prepacked columns over a time span of ten years

  Autoren: Scharl, T; Schweiger, S; Jungreuthmayer, C; Dürauer, A; Schröder, T; Jungbauer, A

  Event: 29th International Symposium on Preparative and Process Chromatography PRREP 2016

• Year: 2016 -  Real-time monitoring of quantity, purity and potency of biopharmaceuticals in purification processes

  Autoren: Sauer, D; Walch, N; Felföldi, E; Mayer-Maschl, S; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer,A; Jungbauer, A

  Event: ESIB – European Summit of Industrial Biotechnology

• Year: 2016 -  Real-time monitoring of quantity, purity and potency of biopharmaceuticals in purification processes

  Autoren: Walch, N; Sauer, D; Felföldi, E; Mayer-Maschl, S; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A

  Event: European Summit of Industrial Biotechnology ESIB 2016

• Year: 2016 -  Prediction of key parameters in the production of biopharmaceuticals using R

  Autoren: Scharl, T; Melcher, M; Striedner, G; Leisch, F

  Event: UseR! 2016

• Year: 2016 -  Real-time monitoring of purification processes – vision or reality?

  Autoren: Sauer, D.,Walch, N., Felföldi, E., Mayer-Maschl, S., Scharl-Hirsch, T.,Melcher, M., Leisch, F., Dürauer, A., Jungbauer, A.

  Event: Evon Up 2 Date

• Year: 2015 -  Statistical Modeling in Bioprocess Monitoring

  Autoren: Melcher, M; Scharl, T; Luchner, M; Striedner, G; Leisch, F

  Event: Statistiktage 2015

• Year: 2013 -  Outer membrane composition of Escherichia coli does significantly influence overflow-metabolism and consequently acetate secretion.

  Autoren: Mairhofer J; Marisch K; Scharl-Hirsch T; Striedner G

  Event: 7th Conference on Recombinant Protein Production RPP7 2013

• Year: 2013 -  Small Changes, big difference - How a synthetic T7 transcriptional termination signal can improve bioprocess performance.

  Autoren: Mairhofer, J; Marisch, K; Scharl-Hirsch, T; Striedner, G

  Event: 7th Conference on Recombinant Protein Production RPP7 2013

• Year: 2013 -  Online Prediction of Biomass and Product Yield for Recombinant Protein Production in Escherichia Coli Expression Systems

  Autoren: Melcher, M; Scharl, T; Spangl, B; Luchner, M; Cserjan, M; Striedner, G; Leisch, F

  Event: ACIB Science Days 2013

• Year: 2011 -  Host cell response to recombinant gene expression in E. coli based expression systems

  Autoren: Striedner G., Bayer K., Cserjan M., Mairhofer J., Scharl T., Marisch K., Luchner M.: , International Workshop on Biological Products and Bioprocesses, Varadero, Cuba, 26.06.2011 - 30.06.2011

  Event: International Workshop on Biological Products and Bioprocesses 2011

• Year: 2010 -  Quality-Based Clustering of Functional Data: Applications to Time Course Microarray Data

  Autoren: Scharl, T; Leisch, F

  Event: 32nd Annual Conference of the German-Classification-Society 2008

• Year: 2010 -  Analysis of transcriptome and proteome - Escherichia coli cultivation data

  Autoren: Marisch, K; Scharl, T; Strobl, F; Auer, N; Krempl, P; Hummel, K; Razzazi-Fazeli, E; Bayer, K; Striedner, G

  Event: 2nd ÖGMBT Annual Meeting 2010

• Year: 2010 -  Comparative analysis of transcriptome and proteome E. coli cultivation data

  Autoren: Marisch, K., Luchner, M., Scharl-Hirsch, T., Bayer, K., Striedner, G.

  Event: 18th Annual International Conference on Intelligent Systems for Molecular Biology

• Year: 2009 -  Application of transcriptome and proteome analysis for comparative evaluation of industrial E. coli production strains

  Autoren: Karoline Marisch, Norbert Auer, Monika Cserjan, Markus Luchner, Ebrahim Razzazi-Fazeli, Theresa Scharl, Florian Strobl, Gerald Striedner and Karl Bayer

  Event: International Conference on Systems Biology 2009

• Year: 2008 -  Vizualizing Gene Clusters Using Neighborhood Graphs in R.

  Autoren: Scharl,T;Leisch,F;

  Event: 18th Symposium on Computational Statistics COMSTAT 2008

• Year: 2008 -  Using Neighborhood Graphs for the Investigation of E. coli Gene Clusters.

  Autoren: Scharl,T;Leisch,F;

  Event: Computational Systems Biology WCSB 2008

• Year: 2008 -  Monitoring of industrial E. coli strains (K12 and BL21) during batch - cultivations using transcriptome and proteome techniques

  Autoren: Karoline Marisch, Gerald Striedner, Theresa Scharl, Florian Strobl, Norbert Auer, Karin Hummel, Ebrahim Razzazi-Fazeli and Karl Bayer

  Event: 5th Conference on Recombinant Protein Production 2008

• Year: 2006 -  Jackknife distances for clustering time - course gene expression data.

  Autoren: Scharl,T; Leisch,F;

  Event: Joint Statistical Meetings 2006

• Year: 2006 -  The Stochastic QT-clust Algorithm: Evaluation ofStability and Variance on -course Microarray Data.

  Autoren: Leisch, F; Scharl, T;

  Event: Compstat 2006