Theresa Scharl-Hirsch
Dipl.-Ing. Dr. Theresa Scharl-Hirsch
Institut Institute of Statistics
Standort Peter-Jordan-Straße 82, 1190 Wien
Email theresa.scharl@boku.ac.at
Tel: +43 1 47654-85117
Laufbahn
- 2024 Deputy Scientific Head (Core Facility Bioinformatics, University of Natural Resources and Life Sciences, Vienna (BOKU))
- 2020 Senior Scientist, Institute of Statistics, University of Natural Resources and Life Sciences Vienna
- 2009 - 2020 Senior Scientist, Austrian Center of Industrial Biotechnology
- 2004 - 2009 PhD Studies Applied Mathematics, Vienna University of Technology
- 2004 - 2009 Research Associate, Institute of Statistics and Probability Theory, Vienna University of Technology
- 2004 - 2020 Research Associate, Institute of Bioprocess Science and Engineering and Institute of Statistics, University of Natural Ressources and Life Sciences, Vienna
- 1998 - 2004 Studies in Applied Mathematics, Vienna University of Technology
Projekte
Es wurden 0 Projekte gefunden.
Publikationen
Wissentransfer in die Gesellschaft
Medienbeiträge
Vorträge
(2023) A clustering procedure for 3-way RNA-seq data
Autoren: Scharl-Hirsch, T.; Grün, B.
JSM 2023
(2022) Deep learning to predict critical process parameters of an antibody capture process
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
14th Annual Meeting ÖGMBT 2022 - Life Sciences - now more than ever
(2022) Modeling Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models
Autoren: Scharl, T.; Grün, B
Austrian and Slovenian Statistical Days 2022
(2022) Modeling Three-Way RNA Sequencing Data Using Data Transformations and Matrix-Variate Gaussian Mixture Models
Autoren: Scharl, T; Grün, B.
17th Conference of the International Federation of Classification Societies IFCS 2022 - Classification and Data Science in the Digital Age
(2022) Permutation based variable importance determination for deep learning
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
24th International Conference on Computational Statistics COMPSTAT 2022
(2022) Deep Learning for Modelling High-dimensional Data of a Biopharmaceutical Purification Process
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
Austrian and Slovenian Statistical Days 2022
(2022) Time Resolved Feature Importance of a Biopharmaceutical Purification Process Using Permutation Based Methods
Autoren: Matthias Medl, Theresa Scharl, Astrid Dürauer, Friedrich Leisch
17th Conference of the International Federation of Classification Societies IFCS 2022 - Classification and Data Science in the Digital Age
(2022) Modeling three-Way RNA sequencing data using matrix-variate Gaussian mixture models
Autoren: Scharl, T; Grün, B
24th International Conference on Computational Statistics COMPSTAT 2022
(2021) Modeling Three-Way RNA Sequencing Data with Mixtures of Multivariate Poisson-Lognormal Distributions
Autoren: Theresa Scharl and Bettina Grün
13th Scientific Meeting of the Classification and Data Analysis Group CLADAG 2021
(2021) Real-Time Monitoring and model-based Prediction of Product Purity and Quantity throughout Downstream Processing of Biopharmaceuticals
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
PREP symposium 2021
(2019) Real-time monitoring and model-based prediction of purity and quantity in a chromatographic step of a biopharmaceutical
Autoren: Sauer, D.; Melcher, M.; Walch, N.; Scharl-Hirsch, T.; Leisch, F.; Jungbauer, A.; Dürauer, A.
PREP Symposium 2019
(2019) Hybrid semi-parametric modeling of preparative protein chromatography for online monitoring and real-time process-control
Autoren: Christler, A; von Stosch, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A
European Congress of Applied Biotechnology ECAB5 2019
(2019) Real-Time Monitoring and model-based Prediction of Purity and Quantity during chromatographic Purification of Biopharmaceuticals
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
BPP 2019
(2019) Real-time prediction of protein quantity and purity in downstream processing
Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Felföldi, E; Christler, A; Jungbauer, A; Dürauer, A; Leisch, F
European Congress of Applied Biotechnology ECAB5 2019
(2019) Real-Time Monitoring and model-based Prediction of Purity and Quantity during chromatographic Purification of Biopharmaceuticals
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
APCChE 2019
(2019) Real-time monitoring and model-based prediction of purity and quantity during chromatographic purification of biopharmaceuticals
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
Asian Pacific Confederation of Chemical Engineering (APCChE)
(2019) Real-time monitoring and model.based prediction of purity and quantity during chromatographic purification of biopharmaceuticals
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
Biopartitioning & Purification Conference (BPP2019)
(2019) Using large data for the prediction of quality attributes of an antibody capture process in real-time
Autoren: Scharl-Hirsch, T; Melcher, M; Felföldi, E; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F
European Congress of Applied Biotechnology ECAB5 2019
(2018) Online Monitoring of quantity, purity, and potency of an antibody capture process
Autoren: Walch, N; Sauer, D; Felföldi, E; Dürauer, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A
255th National Spring Meeting of the American Chemical Society ACS 2018 - Nexus of Food, Energy, and Water
(2018) Machine Learning in Bioprocess Modeling
Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, DG; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F
Data Science, Statistics & Visualisation DSSV 2018
(2018) Real-Time Monitoring ofquantity, potency and purity of FGF-2 in a chromatographic capture process
Autoren: Sauer, D; Walch, N; Melcher, M; Scharl-Hirsch, T;, P; Jungbauer, A; Dürauer A.
Bioproduction 2018
(2018) Model Based Real Time Monitoring in Chromatography
Autoren: Sauer, D; Walch, N; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
Recovery of Biological Products 2018
(2018) Online monitoring of quantity, purity and potency of an antibody capture process
Autoren: Walch, N; Sauer, D; Felfoldi, E; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Durauer, A
255th National Spring Meeting of the American Chemical Society ACS 2018 - Nexus of Food, Energy, and Water
(2018) Handling of large data in protein chromatography
Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F;
12th European Symposium on Biochemical Engineering Sciences ESBES 2018
(2018) Handling of large data in a protein purification process
Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F;
Data Science, Statistics & Visualisation DSSV 2018
(2018) Real-Time Monitoring ofquantity, potency and purity of FGF-2 in a chromatographic capture process
Autoren: Sauer, D; Walch, N; Melcher, M; Scharl-Hirsch, T;, P; Jungbauer, A; Dürauer A.
European Symposium On Biochemical Engineering Sciences 2018
(2018) Real-time prediction of quantity, purity and impurities during antibody capture
Autoren: Walch, N; Sauer, D; Felföldi, E; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
SBCN 2018
(2017) Real-time monitoring of quantity and purity of fibroblast growth factor-2 during the chromatographic capture step
Autoren: Sauer, D; Walch, N; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
International Symposium on Preparative and Process Chromatography PREP 2017
(2017) Real-time monitoring of purity, quantity and potency of fibroblast growth factor-2 during chromatographic capture and polishing steps
Autoren: Sauer, D., Walch, N., Scharl-Hirsch, T., Melcher, M., Leisch, F., Jungbauer, A., Dürauer, A.
ECAB 2017
(2017) Online Monitoring of Quantity, Purity and Potency of an Antibody Capture Process
Autoren: Walch, N; Sauer, DG; Felföldi, E; Mosor, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
International Symposium and Exhibit on the Separation of Proteins, Peptides and Polynucleotides (ISPPP) 2017
(2017) Real-Time Monitoring of quantitiy and purity of firbroblast growth factor-2 during a chromatographic capture step
Autoren: Sauer, D.; Walch, N.; Scharl-Hirsch, T.; Melcher, M.; Leisch, F.; Jungbauer, A.; Dürauer, A.
PREP Symposium 2017
(2017) Prediction of fibroblast growth factor-2 protein's qualities in a downstream process: shrinkage regression and variable selection
Autoren: Tumolva, O; Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F
European Summit of Industrial Biotechnology ESIB 2017
(2017) Real-time monitoring of quality attributes during a chromatographic capture step using statistical models
Autoren: Scharl-Hirsch, T; Melcher, M; Sauer, D; Walch, N; Jungbauer, A; Mayer, M; Dürauer, A; Leisch, F
European Summit of Industrial Biotechnology ESIB 2017
(2017) Online monitoring of quantity, purity and potency of an antibody capture process
Autoren: Walch, N., Sauer, D., Felföldi, E., Scharl-Hirsch, T., Melcher, M., Leisch, F., Jungbauer, A., Dürauer, A.
ISPPP 2017
(2017) Online Monitoring of Quantity, Purity and Potency of an Antibody Capture Process
Autoren: Walch, N; Sauer, D; Felföldi, E; Mosor, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
European Summit of Industrial Biotechnology ESIB 2017
(2017) Real-time Prediction of Potency, Purity and Concentration throughout a Chromatographic Capture Step of Basic Fibroblast Growth Factor 2
Autoren: Sauer, DG; Walch, N; Felföldi, E; Mosor, M; Frank, AC; Scharl-Hirsch, T; Melcher, M; Leisch, A; Jungbauer, A; Dürauer, A
International Symposium and Exhibit on the Separation of Proteins, Peptides and Polynucleotides (ISPPP) 2017
(2017) Real-time Prediction of Potency, Purity and Concentration throughout a Chromatographic Capture Step of Basic Fibroblast Growth Factor 2
Autoren: Sauer, D; Walch, N; Felföldi, E; Mosor, M; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Jungbauer, A; Dürauer, A
European Summit of Industrial Biotechnology ESIB 2017
(2016) Statistical evaluation of performance parameters of prepacked columns over a time span of ten years
Autoren: Scharl, T; Schweiger, S; Jungreuthmayer, C; Dürauer, A; Schröder, T; Jungbauer, A
29th International Symposium on Preparative and Process Chromatography PRREP 2016
(2016) Real-time monitoring of quantity, purity and potency of biopharmaceuticals in purification processes
Autoren: Sauer, D; Walch, N; Felföldi, E; Mayer-Maschl, S; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer,A; Jungbauer, A
ESIB – European Summit of Industrial Biotechnology
(2016) Real-time monitoring of quantity, purity and potency of biopharmaceuticals in purification processes
Autoren: Walch, N; Sauer, D; Felföldi, E; Mayer-Maschl, S; Frank, A; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A
European Summit of Industrial Biotechnology ESIB 2016
(2016) Prediction of key parameters in the production of biopharmaceuticals using R
Autoren: Scharl, T; Melcher, M; Striedner, G; Leisch, F
UseR! 2016
(2016) Real-time monitoring of purification processes – vision or reality?
Autoren: Sauer, D.,Walch, N., Felföldi, E., Mayer-Maschl, S., Scharl-Hirsch, T.,Melcher, M., Leisch, F., Dürauer, A., Jungbauer, A.
Evon Up 2 Date
(2015) Statistical Modeling in Bioprocess Monitoring
Autoren: Melcher, M; Scharl, T; Luchner, M; Striedner, G; Leisch, F
Statistiktage 2015
(2013) Outer membrane composition of Escherichia coli does significantly influence overflow-metabolism and consequently acetate secretion.
Autoren: Mairhofer J; Marisch K; Scharl-Hirsch T; Striedner G
7th Conference on Recombinant Protein Production RPP7 2013
(2013) Small Changes, big difference - How a synthetic T7 transcriptional termination signal can improve bioprocess performance.
Autoren: Mairhofer, J; Marisch, K; Scharl-Hirsch, T; Striedner, G
7th Conference on Recombinant Protein Production RPP7 2013
(2013) Online Prediction of Biomass and Product Yield for Recombinant Protein Production in Escherichia Coli Expression Systems
Autoren: Melcher, M; Scharl, T; Spangl, B; Luchner, M; Cserjan, M; Striedner, G; Leisch, F
ACIB Science Days 2013
(2011) Host cell response to recombinant gene expression in E. coli based expression systems
Autoren: Striedner G., Bayer K., Cserjan M., Mairhofer J., Scharl T., Marisch K., Luchner M.: , International Workshop on Biological Products and Bioprocesses, Varadero, Cuba, 26.06.2011 - 30.06.2011
International Workshop on Biological Products and Bioprocesses 2011
(2010) Quality-Based Clustering of Functional Data: Applications to Time Course Microarray Data
Autoren: Scharl, T; Leisch, F
32nd Annual Conference of the German-Classification-Society 2008
(2010) Analysis of transcriptome and proteome - Escherichia coli cultivation data
Autoren: Marisch, K; Scharl, T; Strobl, F; Auer, N; Krempl, P; Hummel, K; Razzazi-Fazeli, E; Bayer, K; Striedner, G
2nd ÖGMBT Annual Meeting 2010
(2010) Comparative analysis of transcriptome and proteome E. coli cultivation data
Autoren: Marisch, K., Luchner, M., Scharl-Hirsch, T., Bayer, K., Striedner, G.
18th Annual International Conference on Intelligent Systems for Molecular Biology
(2009) Application of transcriptome and proteome analysis for comparative evaluation of industrial E. coli production strains
Autoren: Karoline Marisch, Norbert Auer, Monika Cserjan, Markus Luchner, Ebrahim Razzazi-Fazeli, Theresa Scharl, Florian Strobl, Gerald Striedner and Karl Bayer
International Conference on Systems Biology 2009
(2008) Vizualizing Gene Clusters Using Neighborhood Graphs in R.
Autoren: Scharl,T;Leisch,F;
18th Symposium on Computational Statistics COMSTAT 2008
(2008) Using Neighborhood Graphs for the Investigation of E. coli Gene Clusters.
Autoren: Scharl,T;Leisch,F;
Computational Systems Biology WCSB 2008
(2008) Monitoring of industrial E. coli strains (K12 and BL21) during batch - cultivations using transcriptome and proteome techniques
Autoren: Karoline Marisch, Gerald Striedner, Theresa Scharl, Florian Strobl, Norbert Auer, Karin Hummel, Ebrahim Razzazi-Fazeli and Karl Bayer
5th Conference on Recombinant Protein Production 2008
(2006) Jackknife distances for clustering time - course gene expression data.
Autoren: Scharl,T; Leisch,F;
Joint Statistical Meetings 2006
(2006) The Stochastic QT-clust Algorithm: Evaluation ofStability and Variance on -course Microarray Data.
Autoren: Leisch, F; Scharl, T;
Compstat 2006
Application of CNN ensembles to model Fourier transform infrared spectra
Autoren: Matthias Medl, Theresa Scharl, Friedrich Leisch
Real Time Monitoring and Model-Based Prediction of Purity and Quantity of Biopharmaceuticals
Autoren: Sauer, D; Melcher, M; Walch, N; Scharl-Hirsch, T; Leisch, F; Jungbauer, A; Dürauer, A
Statistical Models in Up- and Downstream processing: their merits, limitations and realization with R
Autoren: Theresa Scharl
Modeling the Protein Quantity and Purity in Downstream Processing using Methods of Statistical Learning
Autoren: Melcher, M; Scharl-Hirsch, T; Sauer, D; Walch, N; Felfäldi, E; Christler, A; Jungbauer, A; Dürauer, K; Leisch, F
Efficient identification of optimal process conditions with Gaussian processes
Autoren: Medl, M; Winter, M; Erdem, I; Dürauer, A; Scharl, T;
Handling large data for the prediction of quality attributes of an antibody capture process in real-time
Autoren: Scharl-Hirsch, T; Melcher, M; Felföldi, E; Sauer, D; Walch, N; Jungbauer, A; Dürauer, A; Leisch, F
Uncovering the black-box of data-driven models in biotechnological process modeling
Autoren: Matthias Medl, Theresa Scharl, Friedrich Leisch, Astrid Dürauer
Hybrid semi-parametric modeling of preparative protein chromatography for online monitoring and real-time process control
Autoren: Christler, A; Felföldi, E; von Stosch, M; Scharl-Hirsch, T; Melcher, M; Leisch, F; Dürauer, A; Jungbauer, A