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Ionenbildung in der Ionenmobilitätsmassenspektrometrie

Projektleitung
Valadbeigi Younes, Projektleiter/in
Laufzeit:
01.11.2020-28.02.2023
Programm:
Lise-Meitner Stipendium
Art der Forschung
Grundlagenforschung
Mitarbeiter*innen
Causon Tim, Sub-Projektleiter/in
Beteiligte BOKU-Organisationseinheiten
Institut für Analytische Chemie (DCH/AC)
Gefördert durch
Fonds zur Förderung der wissenschaftlichen Forschung (FWF) , Sensengasse 1, 1090 Wien, Österreich
Abstract
The combination of ion mobility-mass spectrometry (IM-MS) with separation techniques such as liquid chromatography (LC) is now emerging as a powerful platform for addressing the identity confirmation of unknown organic compounds within complex samples. Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) are two widespread ion sources for IM-MS, in which the mechanism of ionization is based on protonation/deprotonation of the analyte or cation/anion attachment. Studying these phenomena theoretically alongside experimental confirmation on a commercially available instrument is recognized as a key aspect of addressing the broad analysis of unknown compounds via untargeted workflows, where several 1000 molecular features are typically resolved within a single LC-IM-MS analysis. In an IM-MS platform equipped with APCI or ESI ion sources, the formation of the product ions and consequently the sensitivity of IM-MS to a given analyte, M, depends on the nature of M, the source conditions applied, and solvents during ionization processes. As such, establishing an improved knowledge about the ion/molecule reactions occurring in the ionization region of an IM-MS, potential conformations of ionic species, the nature of the ion/molecule interactions, and the parameters influencing these interactions enables analytical chemists to modify the existing analytical techniques to improve their detection limits and sensitivities, provide better characterization of unknown molecules, and/or to avoid some interferences that reduce the analytical performance.
Schlagworte
Analytische Chemie; Physikalische Chemie; Theoretische Chemie;
Analytische Chemie; APCI; ESI; Ionenmobilitätsmassenspektrometrie; Theoretische Chemie;
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