Workshop on High Throughput Process Development
Abstract
Biotech industry has adopted HT screening/micro well plates as process development tools, the major question remains on how the process can be optimised, so that it is representative of the large scale. Conversely what are the criteria for scaling-up the process developed at the microscale to large scale systems? Meanwhile technologies of even smaller dimensions such a microfluidic devices, lab-on-a chip approaches and HTPD on the nanoscale are discussed as state of the art for process development in the biotech community. Successful application of HT systems for process development depends on the right choice of technology in combination with Design of experiment strategies or mechanistic modelling and statistical evaluation of the obtained data.The workshop will focus on - Microscale methods for process development in up and downstream processing – case studies, commercial systems - Scale up / down rules for process development in up and downstream processing and its limitations - Microfluidic devices for up and downstream processing and its limitations - Lab on a chip approach for process development in up and downstream processing - Application of DoE and statistical evaluation of large data - Nanoscale devices to predict process data
keywords process development microtiter plates scale up microfluidic devices
Publikationen
Project staff
Astrid Dürauer
Priv.-Doz. Dipl.-Ing. Dr. Astrid Dürauer
astrid.duerauer@boku.ac.at
Tel: +43 1 47654-79095
BOKU Project Leader
01.01.2020 - 30.04.2023
BOKU partners
External partners
ACIB GmbH
none
partner