Measurement of cisplatin, carboplatin, 5-fluorouracil and methotrexate concentrations in head and neck cancers by in vivo microdialysis.
Abstract
Cisplatin, carboplatin, 5-fluorouracil and methotrexate concentrations in head and neck cancers are collected by in vivo microdialysis. The Pt concentration is subsequently analysed by means of HR-ICPMS. A speciation by online coupling of a chromatographical system to the HR-ICPMS is planned. Aims of the study: 1. To describe the time versus concentration profile in tumor tissue of the study drugs as a measure of tumor exposure. 2. To compare the tissue / plasma ratios as a measure of tumor penetration. 3. To describe the time versus concentration profile in the subcutaneous adipose tissue for the study drugs as a measure of drug exposure of normal tissue.
ICP-MS cancer platinum
Publikationen
Project staff
Gerhard Josef Stingeder
Univ.-Prof. i.R. Dipl.-Ing. Dr.techn. Gerhard Josef Stingeder
gerhard.stingeder@boku.ac.at
Project Leader
01.01.1997 - 31.08.2000
Gunda Köllensperger
Ao.Univ.Prof. Dipl.-Ing. Dr.nat.techn. Gunda Köllensperger
gunda.koellensperger@boku.ac.at
Project Staff
01.01.1997 - 31.08.2000
BOKU partners
External partners
AKH, Klinische Pharmakologie
M. Brunner
partner