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Development of hypoallergenic plants

Subproject of: Danube Allergy Research Cluster – Towards the cure of allergy (Danube ARC)

Project Leader

Grausgruber Heinrich, Project Leader

Duration:

01.08.2020-31.07.2023

Programme:

Großprojekte

Type of Research

Applied Research

Project partners

Karl Landsteiner University of Health Sciences, Dr.-Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Contact person: Rudolf Valenta;
Function of the Project Partner: Partner

Medical University Vienna, Wien, Austria.
Contact person: Rudolf Valenta;
Function of the Project Partner: Partner

Staff

Vollmann Johann, Project Staff

Call Lisa-Maria, Project Staff

Krisai Andrea, Project Staff

BOKU Research Units

Institute of Plant Breeding

Funded by

Amt der Niederösterreichischen Landesregierung, Landhausplatz 1, A-3109 St. Pölten, Austria

Abstract

The subproject aims to identify hypoallergenic wheat and soy species, which lack or contain lower levels of allergens but preserve their nutritional value. To identify hypoallergenic wheat and soy species, different wheat species and soybean germplasm will be screened with allergen-specific antibody probes for the presence and amounts of important wheat and/or soy allergens. In addition, a screening of species and their tissues with IgE antibodies from allergic patients will be performed and the allergenic activity of the species will be tested in basophil activation tests to identify hypoallergenic cultivars. Furthermore, we will search for wheat cultivars containing low levels of food allergens using sera from subjects suffering from food allergy, CD and NCWS. The subproject should lead to the identification of hypoallergenic wheat and soy germplasm to be utilized in breeding programs. It is envisaged that planting and ultilization of hypoallergenic wheat and soy germplasm will reduce the frequencies of allergic sensitization and thus contribute to allergy prevention.

Keywords

Pathophysiology; Allergology; Nutritional sciences; Plant breeding; Food testing;

allergens; food; soybean; wheat;