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Development of hypoallergenic plants

Subproject of: Danube Allergy Research Cluster – Towards the cure of allergy (Danube ARC)

Project Leader
Grausgruber Heinrich, Project Leader
Duration:
01.08.2020-31.07.2023
Programme:
Großprojekte
Type of Research
Applied Research
Project partners
Karl Landsteiner University of Health Sciences, Dr.-Karl-Dorrek-Straße 30, 3500 Krems, Austria.
Contact person: Rudolf Valenta;
Function of the Project Partner: Partner
Medical University Vienna, Wien, Austria.
Contact person: Rudolf Valenta;
Function of the Project Partner: Partner
Staff
Vollmann Johann, Project Staff
Call Lisa-Maria, Project Staff
Krisai Andrea, Project Staff
BOKU Research Units
Institute of Plant Breeding
Funded by
Amt der Niederösterreichischen Landesregierung, Landhausplatz 1, A-3109 St. Pölten, Austria
Abstract
The subproject aims to identify hypoallergenic wheat and soy species, which lack or contain lower levels of allergens but preserve their nutritional value. To identify hypoallergenic wheat and soy species, different wheat species and soybean germplasm will be screened with allergen-specific antibody probes for the presence and amounts of important wheat and/or soy allergens. In addition, a screening of species and their tissues with IgE antibodies from allergic patients will be performed and the allergenic activity of the species will be tested in basophil activation tests to identify hypoallergenic cultivars. Furthermore, we will search for wheat cultivars containing low levels of food allergens using sera from subjects suffering from food allergy, CD and NCWS. The subproject should lead to the identification of hypoallergenic wheat and soy germplasm to be utilized in breeding programs. It is envisaged that planting and ultilization of hypoallergenic wheat and soy germplasm will reduce the frequencies of allergic sensitization and thus contribute to allergy prevention.
Keywords
Pathophysiology; Allergology; Nutritional sciences; Plant breeding; Food testing;
allergens; food; soybean; wheat;
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