Speciation of cancerostatic Pt compounds in the environment
Abstract
The proposed project focuses on the development of analytical methods for identification and quantification of cancerostatic platinum compounds (CPC) and their metabolites in human excretions, in hospital effluents and in surface water. Nowadays the use of CPC has gained undisputed importance in the chemotherapy of several types of cancer. Consequently, CPC are continuously spread into the environment with excretion into wastewater being the major source. The active substances and their metabolites are expected to pass through municipal sewage treatment plants, reaching surface and ground waters. Biotransformation processes, mobility and fate of these compounds in the aquatic environment have not been studied so far, even though their toxicity (carcinogenic, mutagenic, fetotoxic) is well demonstrated. The metabolism of these substances has to be investigated in different aquatic media, in order to support future studies, which aim at the assessment of health risks and environmental impact. New analytical approaches will be applied to samples representing different stages of the water cycle in order to study biotransformation, degradation and adsorption processes. Highly sensitive and specific miniaturized high performance liquid chromatography ¿ inductively coupled sector field mass spectrometry (¿HPLC-ICP-SFMS) will be applied for solving this challenging analytical problem. As complementary detection method electrospray mass spectrometry will be employed. The new findings will give first indications for the state of CPC in the aquatic environment. Furthermore the obtained results will be the base for the development of new strategies for elimination of the substances from hospital effluents.
platinum LC-ICP-MS cancerostatic platinum compounds hospital effluents LC-MS
Publikationen
Project staff
Stephan Hann
Univ.Prof. Dr. Stephan Hann
stephan.hann@boku.ac.at
Tel: +43 1 47654-77001, 77191
Project Leader
03.03.2003 - 02.03.2006
Maria Fürhacker
Ao.Univ.Prof.i.R. Dipl.-Ing. Dr.nat.techn. Maria Fürhacker
maria.fuerhacker@boku.ac.at
Project Staff
03.03.2003 - 02.03.2006
Gerhard Josef Stingeder
Univ.-Prof. i.R. Dipl.-Ing. Dr.techn. Gerhard Josef Stingeder
gerhard.stingeder@boku.ac.at
Project Staff
03.03.2003 - 02.03.2006
BOKU partners
External partners
Vienna University School of Medicine, Department of Internal Medicine I
Robert Mader
partner
Johannes Kepler University Linz, Department of Analytical Chemistry
Wolfgang Buchberger
partner