Generation of antiidiotypic antibodies (AIA) against 2F5 and 2G12 for mimicking conserved envelope epitopes of HIV-1 and for diagnostic purpose
Abstract
The generation of an effective vaccine against HIV1 is one of the most important items in todays health care. However, antigenic variation and resistance of primary isolates to neutralization are currently the bottleneck of vaccine development. In this project we will generate antiidiotypic antibodies (AIAs) by immunizing Balb/c mice with two neutralizing anti HIV-1 antibodies developed in our institute. Such antiidiotypic antibodies are able to mimick the six aminoacid epitope of 2F5 and the structural epitope of 2G12 for enhancing the immunogenic properties of the epitopes. Thus, the AIAs represent a vaccine against HIV by inducing a third generation of antibodies with similar neutralizing properties like 2F5 and 2G12.
neutralizing antibodies anti-idiotypic antibodies HIV-vaccine
Publikationen
Project staff
Renate Kunert
Univ.Prof. Dipl.-Ing. Dr.nat.techn. Renate Kunert
renate.kunert@boku.ac.at
Tel: +43 1 47654-79852
Project Leader
01.01.1998 - 31.12.2000