BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem
Gewählte Publikation:
Stukova, MA; Sereinig, S; Zabolotnyh, NV; Ferko, B; Kittel, C; Romanova, J; Vinogradova, TI; Katinger, H; Kiselev, O; Egorov, A.
(2006):
Vaccine potential of influenza vectors expressing Mycobacterium tuberculosis ESAT-6 protein
TUBERCULOSIS. TUBERCULOSIS; 86: 236-246.
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- Abstract:
- We generated several attenuated recombinant influenza A vectors expressing the Mycobacterium tuberculosis early secretory antigenic target (ESAT-6) protein. The ESAT-6 protein was recently identified as one of the most promising protective antigens for cell-mediated immunity. The obtained vectors appeared to be capable of inducing ESAT-6 specific Th1 immune response in mice after intranasal immunization. We found that double immunization with two influenza vectors of different subtypes provided a significant level of protection in mice, when applied as prophylactic vaccine, as well as substantial therapeutic effect in mice with preestablished tuberculosis infection. Moreover, we found a strong synergistic effect when vaccination with Flu/ESAT-6 vectors was combined with isoniazid treatment, resulting in a dramatic reduction of bacterial. toad in the lungs of infected mice. (c) 2006 Elsevier Ltd. All rights reserved.
- Autor*innen der BOKU Wien:
- Katinger Hermann
- Find related publications in this database (using NML MeSH Indexing)
- Administration, Intranasal -
- Animals -
- Antigens, Bacterial - genetics
- Antitubercular Agents - therapeutic use
- Bacterial Proteins - genetics
- Combined Modality Therapy -
- Genetic Vectors - administration & dosage
- Immunity, Cellular -
- Immunization - methods
- Influenza A virus - genetics
- Isoniazid - therapeutic use
- Mice -
- Mice, Inbred C57BL -
- Mycobacterium tuberculosis - immunology
- Th1 Cells - immunology
- Tuberculosis - immunology
- Tuberculosis Vaccines - immunology
- Find related publications in this database (Keywords)
- tuberculosis vaccine
- influenza
- ESAT-6
- therapy
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