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Gewählte Publikation:

Nathanail, AV; Varga, E; Meng-Reiterer, J; Bueschl, C; Michlmayr, H; Malachova, A; Fruhrnann, P; Jestoi, M; Peltonen, K; Adam, G; Lemmens, M; Schuhmacher, R; Berthiller, F.
(2015): Metabolism of the Fusarium Mycotoxins T-2 Toxin and HT-2 Toxin in Wheat
J AGR FOOD CHEM. 2015; 63(35): 7862-7872. FullText FullText_BOKU

Abstract:
To investigate the metabolic fate of HT-2 toxin (HT2) and T-2 toxin (T2) in wheat (Triticum aestivum L.), an untargeted metabolomics study utilizing stable isotopic labeling and liquid chromatography high resolution mass spectrometry was performed. In total, 11 HT2 and 12 T2 derived in planta biotransformation products were annotated putatively. In addition to previously reported mono- and diglucosylated forms of HT2, evidence for the formation of HT2-malonyl-glucoside and feruloyl-T2, as well as acetylation and deacetylation products in wheat was obtained for the first time. To monitor the kinetics of metabolite formation, a time course experiment was conducted involving the Fusarium head blight susceptible variety Remus and the resistant cultivar CM-82036. Biotransformation reactions were observed already at the earliest tested time point (6 h after treatment), and formed metabolites showed different kinetic profiles. After ripening, less than 15% of the toxins added to the plants were determined to be unmetabolized.
Autor*innen der BOKU Wien:
Adam Gerhard
Berthiller Franz
Büschl Christoph
Lemmens Marc
Malachova Alexandra
Meng-Reiterer Jacqueline
Michlmayr Herbert
Schuhmacher Rainer
Varga Elisabeth
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Find related publications in this database (Keywords)
trichothecenes
masked mycotoxins
cereals
liquid chromatography-high resolution mass spectrometry
metabolomics
stable isotopes


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