BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem

Logo BOKU-Forschungsportal

Gewählte Publikation:

Hochstoeger, T; Al Said, T; Maestre, D; Walter, F; Vilceanu, A; Pedron, M; Cushion, TD; Snider, W; Nimpf, S; Nordmann, GC; Landler, L; Edelman, N; Kruppa, L; Durnberger, G; Mechtler, K; Schuechner, S; Ogris, E; Malkemper, EP; Weber, S; Schleicher, E; Keays, DA.
(2020): The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor
SCI ADV. 2020; 6(33), eabb9110 FullText FullText_BOKU

The biophysical and molecular mechanisms that enable animals to detect magnetic fields are unknown. It has been proposed that birds have a light-dependent magnetic compass that relies on the formation of radical pairs within cryptochrome molecules. Using spectroscopic methods, we show that pigeon cryptochrome clCRY4 is photoreduced efficiently and forms long-lived spin-correlated radical pairs via a tetrad of tryptophan residues. We report that clCRY4 is broadly and stably expressed within the retina but enriched at synapses in the outer plexiform layer in a repetitive manner. A proteomic survey for retinal-specific clCRY4 interactors identified molecules that are involved in receptor signaling, including glutamate receptor-interacting protein 2, which colocalizes with clCRY4. Our data support a model whereby clCRY4 acts as an ultraviolet-blue photoreceptor and/or a light-dependent magnetosensor by modulating glutamatergic synapses between horizontal cells and cones.
Autor*innen der BOKU Wien:
Landler Lukas
BOKU Gendermonitor:

© BOKU Wien Impressum