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Gewählte Publikation:

Kodar, K; Stadlmann, J; Klaamas, K; Sergeyev, B; Kurtenkov, O.
(2012): Immunoglobulin G Fc N-glycan profiling in patients with gastric cancer by LC-ESI-MS: relation to tumor progression and survival
GLYCOCONJUGATE J. 2012; 29(1): 57-66. FullText FullText_BOKU

Abstract:
The IgG Fc glycans strongly influence the Fc. receptor interactions and Fc-mediated effector mechanisms. Changes in the structure of IgG glycans are associated with various diseases, such as infections and autoimmunity. However, the possible role of Fc glycans in tumor immunity is not yet fully understood. The aim of this study was to profile the Fc N-glycans of IgG samples from patients with gastric cancer (n=80) and controls (n=51) using LC-ESI-MS method to correlate the findings with stage of cancer and patients survival. Analysis of 32 different IgG N-glycans revealed significant increase of agalactosylated (GnGnF, GnGn(bi) F), and decrease of galactosylated (AGn(bi), AGn (bi) F, AA(bi), AAF) and monosialylated IgG glycoforms (NaAF, NaA(bi)) in cancer patients. A statistically significant increase of Fc fucosylation was observed in tumor stage II and III whereas reverse changes were found for the presence of bisecting GlcNAc. Higher level of fully sialylated glycans and elevated expression of glycans with bisecting GlcNAc were associated with better survival rate. Our findings provide the first evidence that the changes in Fc glycan profile may predict the survival of patients with gastric cancer. Cancer stage-dependent changes in Fc fucosylation and the bisecting N-acteylglucosamine expression as well as an association of several IgG glycoforms with the survival suggest that IgG glycosylation is related to pathogenesis of cancer and progression of the disease.
Autor*innen der BOKU Wien:
Stadlmann Johannes
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor/blood*
Case-Control Studies
Chromatography, Liquid
Disease Progression
Female
Humans
Immunoglobulin Fc Fragments/blood*
Immunoglobulin Fc Fragments/metabolism
Immunoglobulin G/blood*
Immunoglobulin G/metabolism
Male
Middle Aged
Neoplasm Staging
Polysaccharides/analysis*
Polysaccharides/metabolism
Prognosis
Spectrometry, Mass, Electrospray Ionization
Stomach Neoplasms/blood
Stomach Neoplasms/mortality*
Stomach Neoplasms/pathology*

Find related publications in this database (Keywords)
IgG glycosylation
Fc
Cancer
Survival
Mass spectrometry


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