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Gewählte Publikation:

Nyanhongo, GS; Sygmund, C; Ludwig, R; Prasetyo, EN; Guebitz, GM.
(2013): An antioxidant regenerating system for continuous quenching of free radicals in chronic wounds.
Eur J Pharm Biopharm. 2013; 83(3):396-404 FullText FullText_BOKU

Abstract:
A novel antioxidant regenerating system consisting of cellobiose dehydrogenase (CDH), cellobiose, and phenolic antioxidants with potential application for continuous quenching of free radical species in chronic wounds was developed. This antioxidant regenerating system, continuously quenched in situ produced (NO)-N-center dot, O-2(center dot-) and OH center dot radicals and the produced oxidized phenolic antioxidants were regenerated back to their original parent compounds by CDH using cellobiose as electron donor. This system therefore prevented the accumulation of oxidized phenolic antioxidants. Interestingly, this study also challenges the relevance of using total antioxidant capacities values of plant crude extracts obtained using biologically none relevant radical species like (2,2-diphenyl-1-picrylhydrazyl (DPPH)), Trolox Equivalent Antioxidant Capacity (TEAC), etc. when applied as medicinal remedies. This is because methoxylated phenolic antioxidants like sinapic acid, ferulic acid; 2,6-dimethoxyphenol readily donate their electrons to these radicals (DPPH, TEAC, etc.), thereby greatly influencing the total antioxidant values although this study showed that-they are not at all effective in quenching O-2(center dot-) radicals and again are not the most effective quenchers of (NO)-N-center dot and OH center dot radicals as demonstrated during this study. (C) 2012 Elsevier B.V. All rights reserved.
Autor/innen der BOKU Wien:
Gübitz Georg
Ludwig Roland
Nyanhongo Gibson Stephen
Sygmund Christoph
BOKU Gendermonitor:


Find related publications in this database (Keywords)
Free radicals
Free radical generating system
Antioxidants
Antioxidant regenerating system
Cellobiose dehydrogenase
Cellobiose


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