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Gewählte Publikation:

Fruhmann, P; Skrinjar, P; Weber, J; Mikula, H; Warth, B; Sulyok, M; Krska, R; Adam, G; Rosenberg, E; Hametner, C; Frohlich, J.
(2014): Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin
TETRAHEDRON. 2014; 70(34): 5260-5266. FullText FullText_BOKU

The synthesis of several sulfates of trichothecene mycotoxins is presented. Deoxynivalenol (DON) and its acetylated derivatives were synthesized from 3-acetyldeoxynivalenol (3ADON) and used as substrate for sulfation in order to reach a series of five different DON-based sulfates as well as T2-toxin-3-sulfate. These substances are suspected to be formed during phase-II metabolism in plants and humans. The sulfation was performed using a sulfuryl imidazolium salt, which was synthesized prior to use. All protected intermediates and final products were characterized via NMR and will serve as reference materials for further investigations in the fields of toxicology and bioanalytics of mycotoxins. (C) 2014 The Authors. Published by Elsevier Ltd. All rights reserved.
Autor*innen der BOKU Wien:
Adam Gerhard
Krska Rudolf
Sulyok Michael
Warth Benedikt
BOKU Gendermonitor:

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