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Gewählte Publikation:

Grunewald, TA; Rennhofer, H; Hesse, B; Burghammer, M; Stanzl-Tschegg, SE; Cotte, M; Loffler, JF; Weinberg, AM; Lichtenegger, HC.
(2016): Magnesium from bioresorbable implants: Distribution and impact on the nano- and mineral structure of bone
BIOMATERIALS. 2016; 76: 250-260. FullText FullText_BOKU

Biocompatibility is a key issue in the development of new implant materials. In this context, a novel class of biodegrading Mg implants exhibits promising properties with regard to inflammatory response and mechanical properties. The interaction between Mg degradation products and the nanoscale structure and mineralization of bone, however, is not yet sufficiently understood. Investigations by synchrotron microbeam x-ray fluorescence (mu XRF), small angle x-ray scattering (mu SAXS) and x-ray diffraction (mu XRD) have shown the impact of degradation speed on the sites of Mg accumulation in the bone, which are around blood vessels, lacunae and the bone marrow. Only at the highest degradation rates was Mg found at the implant-bone interface. The Mg inclusion into the bone matrix appeared to be non-permanent as the Mg-level decreased after completed implant degradation. mu SAXS and mu XRD showed that Mg influences the hydroxyl apatite (HAP) crystallite structure, because markedly shorter and thinner HAP crystallites were found in zones of high Mg concentration. These zones also exhibited a contraction of the HAP lattice and lower crystalline order. (c) 2015 Elsevier Ltd. All rights reserved.
Autor*innen der BOKU Wien:
Grünewald Tilman
Lichtenegger Helga
Rennhofer Harald
Tschegg Stefanie

Find related publications in this database (Keywords)
Bioresorbable implant
Implant degradation
Bone nanostructure
Bone mineralization
X-ray microfocus techniques

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