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Gewählte Publikation:

Marschalek, J; Farr, A; Marschalek, ML; Domig, KJ; Kneifel, W; Singer, CF; Kiss, H; Petricevic, L.
(2017): Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study
BREAST CARE. 2017; 12(5): 335-339. FullText FullText_BOKU

Abstract:
Background: Due to chemotherapy and estrogen deprivation therapy, genitourinary syndrome of menopause is a common condition in breast cancer patients. We aimed to determine the effect of an orally administered Lactobacillus preparation on the vaginal microbiota in breast cancer patients. Methods: Postmenopausal breast cancer patients receiving chemotherapy, with vaginal atrophy and an intermediate vaginal microbiota (Nugent score 4-6), were either randomized to the intervention group receiving probiotic capsules of 4 Lactobacillus species or to the control group receiving placebo twice daily for 2 weeks. Consecutive vaginal swabs were taken at baseline, 1 day after administration of the last capsule (follow-up 1), and after 1 week (follow-up 2) in 22 patients (11 vs. 11). Results: We observed a positive influence on the vaginal microbiota in 7/11 (63%) women in the intervention group, and 4/11 (36%) women in the control group. There was a shift in Nugent score towards normal microbiota levels in the intervention group (-1.3 at follow-up 1, -0.45 at follow-up 2) and a significant deterioration of the Nugent score in the control group (+0.4 at follow-up 1, +2.5 at follow-up 2). Conclusion: The orally administered Lactobacillus preparation has the potential to improve the vaginal microbiota in women undergoing chemotherapy for breast cancer. (C) 2017 The Author(s). Published by S. Karger GmbH, Freiburg
Autor*innen der BOKU Wien:
Domig Konrad
Kneifel Wolfgang
BOKU Gendermonitor:


Find related publications in this database (Keywords)
Vaginal microbiota
Lactobacillus species
Breast cancer
Chemotherapy
Probiotics
Nugent score


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