BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem
Gewählte Publikation:
Liebi, M; Lutz-Bueno, V; Guizar-Sicairos, M; Schonbauer, BM; Eichler, J; Martinelli, E; Loffler, JF; Weinberg, A; Lichtenegger, H; Grunewald, TA.
(2021):
3D nanoscale analysis of bone healing around degrading Mg implants evaluated by X-ray scattering tensor tomography
ACTA BIOMATER. 2021; 134: 804-817.
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- Abstract:
- The nanostructural adaptation of bone is crucial for its biocompatibility with orthopedic implants. The bone nanostructure also determines its mechanical properties and performance. However, the bone's tem-poral and spatial nanoadaptation around degrading implants remains largely unknown. Here, we present insights into this important bone adaptation by applying scanning electron microscopy, elemental analy-sis, and small-angle X-ray scattering tensor tomography (SASTT). We extend the novel SASTT reconstruc-tion method and provide a 3D scattering reciprocal space map per voxel of the sample's volume. From this reconstruction, parameters such as the thickness of the bone mineral particles are quantified, which provide additional information on nanostructural adaptation of bone during healing. We selected a rat femoral bone and a degrading ZX10 magnesium implant as model system, and investigated it over the course of 18 months, using a sham as control. We observe that the bone's nanostructural adaptation starts with an initially fast interfacial bone growth close to the implant, which spreads by a re-orientation of the nanostructure in the bone volume around the implant, and is consolidated in the later degradation stages. These observations reveal the complex bulk bone-implant interactions and enable future research on the related biomechanical bone responses. Statement of significance Traumatic bone injuries are among the most frequent causes of surgical treatment, and often require the placement of an implant. The ideal implant supports and induces bone formation, while being mechan-ically and chemically adapted to the bone structure, ensuring a gradual load transfer. While magnesium implants fulfill these requirements, the nanostructural changes during bone healing and implant degra-dation remain not completely elucidated. Here, we unveil these processes in rat femoral bones with ZX10 magnesium implants and show different stages of bone healing in such a model system. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of Acta Materialia Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
- Autor*innen der BOKU Wien:
- Lichtenegger Helga
- Schönbauer Bernd
- Find related publications in this database (Keywords)
- Biomineralization
- Implant degradation
- X-ray scattering
- Tomography
- Degradable magnesium implants
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