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Gewählte Publikation:

Lemmens-Gruber, R; Rachoy, B; Steininger, E; Kouri, K; Saleh, P; Krska, R; Josephs, R; Lemmens, M.
(2000): The effect of the Fusarium metabolite beauvericin on electromechanical and -physiological properties in isolated smooth and heart muscle preparations of guinea pigs.
Mycopathologia. 2000; 149(1):5-12

The electromechanical and -physiological effects of beauvericin were studied in isolated smooth and heart muscle preparations of the guinea pig. Beauvericin concentration-dependently decreased the force of contraction in precontracted (60 mM KCl) terminal ilea with an IC50 of 0.86 muM, and in electrically stimulated (1 Hz) papillary muscles with an IC50 of 18 muM. This negative inotropic effect in papillary muscles was antagonised in a non-competitive way by increased extracellular calcium concentrations. Spontaneous activity in right atria was affected at concentrations > 10 muM beauvericin. The negative chronotropic effect was less pronounced than the negative inotropic effect. In action potentials of electrically driven (1 Hz) papillary muscles, 10 muM beauvericin significantly decreased membrane resting potential until unexcitability of the preparation occurred. Despite depolarisation of the membrane the maximum rate of rise of the action potential was not changed. The action potential duration was shortened, but the decrease was only significant at times to 20% and 50% repolarisation. These data, derived from the electrophysiological experiments, not only imply an effect on the calcium current as suggested by the effects on contractility, but also an interaction with the sodium inward and potassium outward currents.
Autor*innen der BOKU Wien:
Krska Rudolf
Lemmens Marc
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Action Potentials - drug effects
Animals - drug effects
Anti-Bacterial Agents - pharmacology
Calcium - pharmacology
Depression, Chemical - pharmacology
Depsipeptides - pharmacology
Female - pharmacology
Fusarium - metabolism
Guinea Pigs - metabolism
Heart Rate - drug effects
Ileum - drug effects
Male - drug effects
Membrane Potentials - drug effects
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Myocardial Contraction - drug effects
Papillary Muscles - cytology
Peptides - cytology

Find related publications in this database (Keywords)
action potential
force of contraction
fusarium metabolite
smooth muscle
heart muscle

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