BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem

Logo BOKU-Forschungsportal

Gewählte Publikation:

Passardi, F; Zamocky, M; Favet, J; Jakopitsch, C; Penel, C; Obinger, C; Dunand, C.
(2007): Phylogenetic distribution of catalase-peroxidases: are there patches of order in chaos?
Gene. 2007; 397(1-2):101-113 FullText FullText_BOKU

Hydrogen peroxide features in many biological oxidative processes and must be continuously degraded enzymatically either via a catalatic or a peroxidatic mechanism. For this purpose ancestral bacteria evolved a battery of different heme and non-heme enzymes, among which heme-containing catalase-peroxidases (CP) are one of the most widespread representatives. They are unique since they can follow both H2O2-degrading mechanisms, the catalase activity being clearly dominant. With the fast increasing amount of genomic data available, we were able to perform an extensive search for CP and found almost 300 sequences covering a large range of microorganisms. Most of them were encoded by bacterial genomes, but we could also find some in eukaryotic organisms other than fungi, which has never been shown until now. Our screen also reveals that approximately 60% of the bacteria do not possess CP genes. Chaotic distribution among species and incongruous phylogenetic reconstruction indicated existence of numerous lateral gene transfers in addition to duplication events and regular speciation. The results obtained show an impressively complex gene transmission pattern, and give some new insights about the role of CP and the origin of life on earth. Finally, we propose for the first time bacterial candidates that may have participated in the transfer of CP from bacteria to eukaryotes. (C) 2007 Elsevier B.V. All rights reserved.
Autor*innen der BOKU Wien:
Jakopitsch Christa
Obinger Christian
Zamocky Marcel
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Animals -
Bacteria - enzymology
Bacterial Proteins - chemistry
Catalytic Domain - chemistry
Eukaryotic Cells - chemistry
Gene Transfer, Horizontal - chemistry
Genes, Bacterial - chemistry
Genomic Islands - chemistry
Models, Molecular - chemistry
Peroxidases - chemistry
Phylogeny - chemistry
Species Specificity - chemistry
Superoxide Dismutase - genetics

Find related publications in this database (Keywords)
catalatic activity
hydrogen peroxide
phylogenctic analysis
lateral gene transfer

© BOKU Wien Impressum