BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem

Logo BOKU-Forschungsportal

Gewählte Publikation:

Buhlert, K; Lehr, M; Jungbauer, A.
(2009): Construction and development of a new single-column simulated moving bed system on the laboratory scale
J CHROMATOGR A. JOURNAL OF CHROMATOGRAPHY A; 1216: 8778-8786. FullText FullText_BOKU

Abstract:
Simulated moving bed (SMB) chromatography combines high productivity and high purities with reduced buffer consumption. We have developed a laboratory scale single column SMB (SC-SMB) unit with all four separation zones in one column. Distributors embedded within the chromatographic medium allow introduction and withdrawal of liquid between the zones. This single column unit exhibits homogenous packing in all zones, reduced headspace, less complex tubing, fewer valves, and almost undisturbed plug flow between the separation zones. The separation performance of the column was investigated with two different binary model mixtures. Furthermore, the SC-SMB unit is operated with a modified AKTA Explorer workstation, which has been specifically developed for the handling of biological fluids. (C) 2009 Elsevier B.V. All rights reserved
Autor*innen der BOKU Wien:
Jungbauer Alois
BOKU Gendermonitor:


Find related publications in this database (Keywords)
Simulated moving bed
Single column
Laboratory scale
Scale down
Embedded distributor


Altmetric:
© BOKU Wien Impressum