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Gewählte Publikation:

Bailer, U; Wiesegger, G; Leisch, F; Fuchs, K; Leitner, I; Letmaier, M; Konstantinidis, A; Stastny, J; Sieghart, W; Hornik, K; Mitterauer, B; Kasper, S; Aschauer, HN.
(2005): No association of clock gene T3111C polymorphism and affective disorders.
Eur Neuropsychopharmacol. 2005; 15(1):51-55 FullText FullText_BOKU

CLOCK was hypothesised to be related to susceptibility of affective disorders. To test subsamples of affectively disordered patients, we examined age of onset (AoO), numbers of episodes and melancholic type of clinical manifestation. Using PCR and RFLP, we investigated in patients with unipolar depression and bipolar disorder (BP) whether the CLOCK T3111C SNP is associated with affective disorders (n = 102) compared to healthy controls (n=103). No differences were found either in genotype or allele frequency distributions of T3111C polymorphism between patients compared to healthy controls (p>0.2). No deviations from Hardy-Weinberg Equilibrium (HWE) were detected either inpatients, or healthy controls. Results suggest that there is no association between the T3111C SNP and affective disorders in general. Data of our sample replicate prior findings of Desan et al. [Am. J. Med. Genet. 12 (2000) 418]. Subsamples of patients with high numbers of affective episodes did show some deviations in genotypes (p=0.0585). (C) 2004 Elsevier B.V. and ECNR All rights reserved.
Autor*innen der BOKU Wien:
Leisch Friedrich
Find related publications in this database (using NML MeSH Indexing)
Adult -
CLOCK Proteins -
Female -
Genotype -
Humans -
Male -
Middle Aged -
Mood Disorders - genetics
Point Mutation -
Polymerase Chain Reaction - methods
Polymorphism, Genetic -
Trans-Activators - genetics

Find related publications in this database (Keywords)
clock gene
T3111C polymorphism
circadian rhythms
affective disorders

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