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Gewählte Publikation:

Schosser, A; Aschauer, HN; Wildenauer, DB; Schwab, SG; Albus, M; Maier, W; Schloegelhofer, M; Leisch, F; Hornik, K; Murray, SS; Gasche, C.
(2007): Homozygosity of the interleukin-10 receptor 1 G330R allele is associated with schizophrenia.
Am J Med Genet B Neuropsychiatr Genet. 2007; 144B(3):347-350 FullText FullText_BOKU

Infections of unknown origin and an altered immune response have been hypothesized to play a role in the pathogenesis of schizophrenia. We have previously identified two single nucleotide polymorphisms (SNPs) of the IL-10 receptor 1 (IL-10R1) causing a substitution of glycine 330 to arginine (G330R) and of serine 138 to glycine (S138G). A possible association between these IL-10R1 variants and schizophrenia has been investigated in the present study. DNA of 101 unrelated Austrian patients with a DSM-III-R (Diagnostic and Statistical Manual of Mental Disorders) consensus diagnosis of schizophrenia (n = 70) or schizoaffective disorder (n = 31) and DNA of 121 German schizophrenic patients (DSM-III-R) was analyzed for the presence of S138G and G330R by allele-specific multiplex PCRs. Data from patients were compared with 250 unrelated, psychiatric healthy controls. No difference in allele frequency was detected between patients and controls (G330R: 34.0% vs. 30.0%, P = 0.208; S138G: 19.7% vs. 16.6%, P = 0.235; by Fisher's exact test). However, there was a significant difference in genotype distribution (wt/wt, wt/mut, mut/mut) for G330R between patients (46.8%, 38.3%, 14.9%) and controls (47.6%, 44.8%, 7.6%; Fisher's test P = 0.032). No such difference was seen for S138G. Our results suggest that homozygosity of the IL-10R1 G330R allele is associated with schizophrenia and may contribute to the expression of disease phenotype in susceptible individuals. (c) 2006 Wiley-Liss, Inc.
Autor*innen der BOKU Wien:
Leisch Friedrich
Find related publications in this database (using NML MeSH Indexing)
Alleles -
Arginine - genetics
Case-Control Studies -
Female -
Gene Frequency -
Genetic Linkage -
Genotype -
Glycine - genetics
Homozygote -
Humans -
Interleukin-10 Receptor alpha Subunit - genetics
Male -
Models, Genetic -
Polymorphism, Single Nucleotide -
Schizophrenia - genetics

Find related publications in this database (Keywords)
schizoaffective disorder

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