BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem
Gewählte Publikation:
Sipos, W; Gerner, W; Schilcher, F; Leeb, C; Groiss, S; Miller, I; Saalmüller, A; Schmoll, F; Schwendenwein, I.
(2006):
Immunophenotypic characterization of peripheral blast cells in a leukemic miniature pig.
Vet Pathol. 2006; 43(3):362-367
FullText
FullText_BOKU
- Abstract:
- The health status of a 4-year-old female, dd-haplotype miniature pig deteriorated rapidly, so the animal finally had to be euthanized because of poor clinical condition. Necropsy revealed a massive leukocytic infiltration in the parenchymatous organs of the abdominal cavity. On hematologic cell counting, severe leukocytosis (69.3 X 10(9) cells/liter) and high-grade basophilia (6.9 X 10(9) cells/liter) were evident. Cytologic examination, as well as analysis of expression of leukocyte differentiation antigens by means of flow cytometry, classified blasts, which accounted for about 22% of leukocytes, as biphenotypic cells co-expressing the myeloid marker SWC3 (CD172a) and the lymphoid markers CD5 and CD25. Hematologic features resembled those seen in humans with chronic myeloid leukemia at blast phase.
- Autor*innen der BOKU Wien:
- Leeb Christine
- Find related publications in this database (using NML MeSH Indexing)
- Animals -
- Female -
- Immunophenotyping -
- Leukemia - immunology
- Leukocytes - immunology
- Liver - pathology
- Ovary - pathology
- Swine -
- Swine Diseases - blood
- Tumor Markers, Biological - metabolism
Altmetric: