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Gewählte Publikation:

Sipos, W; Gerner, W; Schilcher, F; Leeb, C; Groiss, S; Miller, I; Saalmüller, A; Schmoll, F; Schwendenwein, I.
(2006): Immunophenotypic characterization of peripheral blast cells in a leukemic miniature pig.
Vet Pathol. 2006; 43(3):362-367 FullText FullText_BOKU

Abstract:
The health status of a 4-year-old female, dd-haplotype miniature pig deteriorated rapidly, so the animal finally had to be euthanized because of poor clinical condition. Necropsy revealed a massive leukocytic infiltration in the parenchymatous organs of the abdominal cavity. On hematologic cell counting, severe leukocytosis (69.3 X 10(9) cells/liter) and high-grade basophilia (6.9 X 10(9) cells/liter) were evident. Cytologic examination, as well as analysis of expression of leukocyte differentiation antigens by means of flow cytometry, classified blasts, which accounted for about 22% of leukocytes, as biphenotypic cells co-expressing the myeloid marker SWC3 (CD172a) and the lymphoid markers CD5 and CD25. Hematologic features resembled those seen in humans with chronic myeloid leukemia at blast phase.
Autor*innen der BOKU Wien:
Leeb Christine
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Animals -
Female -
Immunophenotyping -
Leukemia - immunology
Leukocytes - immunology
Liver - pathology
Ovary - pathology
Swine -
Swine Diseases - blood
Tumor Markers, Biological - metabolism



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