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Gewählte Publikation:

Korzhikov, V; Roeker, S; Vlakh, E; Kasper, C; Tennikova, T.
(2008): Synthesis of multifunctional polyvinylsaccharide containing controllable amounts of biospecific ligands.
Bioconjug Chem. 2008; 19(3):617-625 FullText FullText_BOKU

In the present study, the attempt to synthesize a multibiofunctional polymeric vector to be used for construction of composite scaffolds for bone tissue engineering has been undertaken. The polymers based on 2-deoxy-2-methacrylamido-D-glucose were functionalized by a growth factor (BMP-2), GRGDSP peptide, and poly(L-lysine) using aldehyde chemistry. The covalent modification process was quantitatively studied, and a polymer conjugate containing all these ligands was formed. In addition, the impacts of coupled ligands toward the adsorption of polymers on the commercial mineral macroporous matrix Sponceram used in cell culture applications were studied.
Autor*innen der BOKU Wien:
Almeria Ciarra
Kasper Cornelia
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
3T3 Cells -
Adsorption -
Aldehydes - chemistry
Animals -
Bone Morphogenetic Protein 2 -
Bone Morphogenetic Proteins - chemistry
Cell Survival - drug effects
Electrophoresis, Polyacrylamide Gel -
Humans -
Indicators and Reagents -
Kinetics -
Ligands -
Mice -
Oligopeptides - chemistry
Polylysine - chemistry
Polysaccharides - chemical synthesis
Polyvinyls - chemical synthesis
Ribonuclease, Pancreatic - metabolism
Ribonucleases - chemistry
Spectrophotometry, Ultraviolet -
Tetrazolium Salts -
Thermodynamics -
Thiazoles -
Tissue Engineering -
Transforming Growth Factor beta - chemistry

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