BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem
Gewählte Publikation:
Smith, RH; Messner, P; Lamontagne, LR; Sleytr, UB; Unger, FM.
(1993):
Induction of T-cell immunity to oligosaccharide antigens immobilized on crystalline bacterial surface layers (S-layers).
Vaccine. 1993; 11(9):919-924
- Abstract:
- Immunization of Balb/c mice with conjugates of oligosaccharide haptens and crystalline bacterial surface-layer proteins (S-layers) primed the mice for a strong, hapten-specific, delayed-type hypersensitivity (DTH) response. Conjugates of haptens with bovine serum albumin produced only weak DTH responses but, when mixed with aluminium hydroxide, elicited DTH responses comparable to those against S-layer conjugates. Surface-layer conjugates also elicited strong anti-hapten DTH responses when administered by an oral/nasal route. Apparently, the natural assembly of S-layer proteins into large, two-dimensional arrays endows them with intrinsic adjuvant properties.
- Autor*innen der BOKU Wien:
- Messner Paul
- Sleytr Uwe B.
- Find related publications in this database (using NML MeSH Indexing)
- Adjuvants, Immunologic -
- Administration, Oral -
- Aluminum Hydroxide - immunology
- Animals -
- Antigens - administration & dosage
- Bacterial Proteins - immunology
- Carbohydrate Sequence -
- Cell Wall - chemistry
- Crystallization -
- Cyclophosphamide - pharmacology
- Drug Carriers -
- Female -
- Haptens - administration & dosage
- Hypersensitivity, Delayed - immunology
- Immunity, Cellular - drug effects
- Immunization - methods
- Immunotherapy, Adoptive -
- Lymphocyte Activation - drug effects
- Mice -
- Mice, Inbred BALB C - immunology
- Molecular Sequence Data -
- Oligosaccharides - administration & dosage
- Serum Albumin, Bovine - immunology
- T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
- CRYSTALLINE BACTERIAL SURFACE LAYERS
- DELAYED-TYPE HYPERSENSITIVITY
- OLIGOSACCHARIDE HAPTENS
- CONJUGATES
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