Gewählte Publikation:
Smith, RH; Messner, P; Lamontagne, LR; Sleytr, UB; Unger, FM.
(1993):
Induction of T-cell immunity to oligosaccharide antigens immobilized on crystalline bacterial surface layers (S-layers).
Vaccine. 1993; 11(9):919-924
- Abstract:
- Immunization of Balb/c mice with conjugates of oligosaccharide haptens and crystalline bacterial surface-layer proteins (S-layers) primed the mice for a strong, hapten-specific, delayed-type hypersensitivity (DTH) response. Conjugates of haptens with bovine serum albumin produced only weak DTH responses but, when mixed with aluminium hydroxide, elicited DTH responses comparable to those against S-layer conjugates. Surface-layer conjugates also elicited strong anti-hapten DTH responses when administered by an oral/nasal route. Apparently, the natural assembly of S-layer proteins into large, two-dimensional arrays endows them with intrinsic adjuvant properties.
- Autor*innen der BOKU Wien:
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Messner Paul
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Sleytr Uwe B.
- Find related publications in this database (using NML MeSH Indexing)
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Adjuvants, Immunologic -
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Administration, Oral -
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Aluminum Hydroxide - immunology
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Animals -
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Antigens - administration & dosage
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Bacterial Proteins - immunology
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Carbohydrate Sequence -
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Cell Wall - chemistry
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Crystallization -
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Cyclophosphamide - pharmacology
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Drug Carriers -
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Female -
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Haptens - administration & dosage
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Hypersensitivity, Delayed - immunology
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Immunity, Cellular - drug effects
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Immunization - methods
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Immunotherapy, Adoptive -
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Lymphocyte Activation - drug effects
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Mice -
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Mice, Inbred BALB C - immunology
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Molecular Sequence Data -
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Oligosaccharides - administration & dosage
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Serum Albumin, Bovine - immunology
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T-Lymphocytes - immunology
- Find related publications in this database (Keywords)
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CRYSTALLINE BACTERIAL SURFACE LAYERS
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DELAYED-TYPE HYPERSENSITIVITY
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OLIGOSACCHARIDE HAPTENS
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CONJUGATES
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