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Gewählte Publikation:

Smith, RH; Messner, P; Lamontagne, LR; Sleytr, UB; Unger, FM.
(1993): Induction of T-cell immunity to oligosaccharide antigens immobilized on crystalline bacterial surface layers (S-layers).
Vaccine. 1993; 11(9):919-924

Abstract:
Immunization of Balb/c mice with conjugates of oligosaccharide haptens and crystalline bacterial surface-layer proteins (S-layers) primed the mice for a strong, hapten-specific, delayed-type hypersensitivity (DTH) response. Conjugates of haptens with bovine serum albumin produced only weak DTH responses but, when mixed with aluminium hydroxide, elicited DTH responses comparable to those against S-layer conjugates. Surface-layer conjugates also elicited strong anti-hapten DTH responses when administered by an oral/nasal route. Apparently, the natural assembly of S-layer proteins into large, two-dimensional arrays endows them with intrinsic adjuvant properties.
Autor*innen der BOKU Wien:
Messner Paul
Sleytr Uwe B.
Find related publications in this database (using NML MeSH Indexing)
Adjuvants, Immunologic -
Administration, Oral -
Aluminum Hydroxide - immunology
Animals -
Antigens - administration & dosage
Bacterial Proteins - immunology
Carbohydrate Sequence -
Cell Wall - chemistry
Crystallization -
Cyclophosphamide - pharmacology
Drug Carriers -
Female -
Haptens - administration & dosage
Hypersensitivity, Delayed - immunology
Immunity, Cellular - drug effects
Immunization - methods
Immunotherapy, Adoptive -
Lymphocyte Activation - drug effects
Mice -
Mice, Inbred BALB C - immunology
Molecular Sequence Data -
Oligosaccharides - administration & dosage
Serum Albumin, Bovine - immunology
T-Lymphocytes - immunology

Find related publications in this database (Keywords)
CRYSTALLINE BACTERIAL SURFACE LAYERS
DELAYED-TYPE HYPERSENSITIVITY
OLIGOSACCHARIDE HAPTENS
CONJUGATES


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