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Gewählte Publikation:

Brzonova, I; Steiner, W; Zankel, A; Nyanhongo, GS; Guebitz, GM.
(2011): Enzymatic synthesis of catechol and hydroxyl-carboxic acid functionalized chitosan microspheres for iron overload therapy.
Eur J Pharm Biopharm. 2011; 79(2):294-303 FullText FullText_BOKU

Excess "free" iron which occurs under certain physiological conditions participates in the formation of toxic reactive oxygen species via the "fenton" chemistry. The reactive oxygen species oxidize biomolecules and have been implicated in many oxidative stress-related diseases. However, the ideal therapy for treating iron overload problems in humans has not yet been developed. In this study, the phenolic molecules catechol, caffeic acid, and 2,5-dihydroxybenzoic acid were successfully coupled to glucosamine as model substrate in a 1:1 ratio using laccase. Furthermore, coupling of these molecules onto chitosans of different sizes was demonstrated, resulting in decrease in -NH(2) groups as quantified via derivatization. A concomitant increase in iron-chelating capacity from below 3% to up to 70% upon phenolic functionalization was measured for the chitosans based on reduced ferrozine/Fe(2+) complex formation. Interesting these phenolic compounds seems to also participate as cross-linkers in producing characteristic microspheres. This work therefore opens-up new strategies aimed at developing a new generation of iron-chelating biomedical polymers. (C) 2011 Elsevier B.V. All rights reserved.
Autor*innen der BOKU Wien:
Gübitz Georg
Nyanhongo Gibson Stephen
Find related publications in this database (using NML MeSH Indexing)
Caffeic Acids - chemistry
Catechols - chemical synthesis
Chitosan - chemical synthesis
Gentisates - chemistry
Glucosamine - chemistry
Hydroxyl Radical - chemistry
Iron - chemistry
Iron Chelating Agents - chemistry
Iron Overload - drug therapy
Laccase - chemistry
Microspheres -
Oxidation-Reduction -
Oxidative Stress -
Reactive Oxygen Species - chemistry

Find related publications in this database (Keywords)
Iron chelators
Oxidative stress
Hydroxyl-carboxic acid
Chitosan microspheres

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