BOKU - Universität für Bodenkultur Wien - Forschungsinformationssystem
Gewählte Publikation:
Brzonova, I; Steiner, W; Zankel, A; Nyanhongo, GS; Guebitz, GM.
(2011):
Enzymatic synthesis of catechol and hydroxyl-carboxic acid functionalized chitosan microspheres for iron overload therapy.
Eur J Pharm Biopharm. 2011; 79(2):294-303
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- Abstract:
- Excess "free" iron which occurs under certain physiological conditions participates in the formation of toxic reactive oxygen species via the "fenton" chemistry. The reactive oxygen species oxidize biomolecules and have been implicated in many oxidative stress-related diseases. However, the ideal therapy for treating iron overload problems in humans has not yet been developed. In this study, the phenolic molecules catechol, caffeic acid, and 2,5-dihydroxybenzoic acid were successfully coupled to glucosamine as model substrate in a 1:1 ratio using laccase. Furthermore, coupling of these molecules onto chitosans of different sizes was demonstrated, resulting in decrease in -NH(2) groups as quantified via derivatization. A concomitant increase in iron-chelating capacity from below 3% to up to 70% upon phenolic functionalization was measured for the chitosans based on reduced ferrozine/Fe(2+) complex formation. Interesting these phenolic compounds seems to also participate as cross-linkers in producing characteristic microspheres. This work therefore opens-up new strategies aimed at developing a new generation of iron-chelating biomedical polymers. (C) 2011 Elsevier B.V. All rights reserved.
- Autor*innen der BOKU Wien:
- Gübitz Georg
- Nyanhongo Gibson Stephen
- Find related publications in this database (using NML MeSH Indexing)
- Caffeic Acids - chemistry
- Catechols - chemical synthesis
- Chitosan - chemical synthesis
- Gentisates - chemistry
- Glucosamine - chemistry
- Hydroxyl Radical - chemistry
- Iron - chemistry
- Iron Chelating Agents - chemistry
- Iron Overload - drug therapy
- Laccase - chemistry
- Microspheres -
- Oxidation-Reduction -
- Oxidative Stress -
- Reactive Oxygen Species - chemistry
- Find related publications in this database (Keywords)
- Iron chelators
- Oxidative stress
- Catechol
- Hydroxyl-carboxic acid
- Chitosan microspheres
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