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Gewählte Publikation:

Bosch, D; Castilho, A; Loos, A; Schots, A; Steinkellner, H.
(2013): N-Glycosylation of Plant-produced Recombinant Proteins
CURR PHARM DESIGN. 2013; 19(31): 5503-5512. FullText FullText_BOKU

Abstract:
Plants are gaining increasingly acceptance as a production platform for recombinant proteins. One reason for this is their ability to carry out posttranslational protein modifications in a similar if not identical way as mammalian cells. The capability of plants to carry out human-like complex glycosylation is well known. Moreover, the targeted manipulation of the plant N-glycosylation pathway allows the production of proteins carrying largely homogeneous, human-type oligosaccharides. These outstanding results have placed plants in a favourable position compared to other eukaryotic expression systems. This review provides a comprehensive summary of the N-glycosylation of plant-produced recombinant proteins, the possible impact of plant-specific N-glycans on the human immune system, and recent advances in engineering the plant N-glycosylation pathway towards the synthesis of (complex) human-type glycan structures, highlighting challenges and achievements in the application of these powerful technologies.
Autor*innen der BOKU Wien:
De Vitoria Pereira Alexandra
Steinkellner Herta
BOKU Gendermonitor:

Find related publications in this database (using NML MeSH Indexing)
Animals
Glycosylation
Humans
Immune System/metabolism
Metabolic Engineering
Molecular Farming/methods*
Plant Proteins/metabolism*
Polysaccharides/chemistry
Polysaccharides/metabolism
Recombinant Proteins/biosynthesis*

Find related publications in this database (Keywords)
Plants
recombinant proteins
glycosylation
glyco-engineering


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