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Gewählte Publikation:

Bouwman, AC; Daetwyler, HD; Chamberlain, AJ; Ponce, CH; Sargolzaei, M; Schenkel, FS; Sahana, G; Govignon-Gion, A; Boitard, S; Dolezal, M; Pausch, H; Brondum, RF; Bowman, PJ; Thomsen, B; Guldbrandtsen, B; Lund, MS; Servin, B; Garrick, DJ; Reecy, J; Vilkki, J; Bagnato, A; Wang, M; Hoff, JL; Schnabel, RD; Taylor, JF; Vinkhuyzen, AAE; Panitz, F; Bendixen, C; Holm, LE; Gredler, B; Hoze, C; Boussaha, M; Sanchez, MP; Rocha, D; Capitan, A; Tribout, T; Barbat, A; Croiseau, P; Drogemuller, C; Jagannathan, V; Jagt, CV; Crowley, JJ; Bieber, A; Purfield, DC; Berry, DP; Emmerling, R; Gotz, KU; Frischknecht, M; Russ, I; Solkner, J; Van Tassell, CP; Fries, R; Stothard, P; Veerkamp, RF; Boichard, D; Goddard, ME; Hayes, BJ.
(2018): Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals
NAT GENET. 2018; 50(3): 362-+. FullText FullText_BOKU

Stature is affected by many polymorphisms of small effect in humans(1). In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes(2,3). Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 x 10(-8)) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.
Autor/innen der BOKU Wien:
Sölkner Johann
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