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Gewählte Publikation:

Amer, H; Mimini, V; Schild, D; Rinner, U; Bacher, M; Potthast, A; Rosenau, T.
(2020): Gram-scale economical synthesis of trans-coniferyl alcohol and its corresponding thiol
HOLZFORSCHUNG. 2020; 74(2): 197-202. FullText FullText_BOKU

Abstract:
Coniferyl alcohol is considered to be a potent antioxidant and a precursor of several bioactive products. In addition, it is a frequently used as a model compound in lignin chemistry. Coniferyl thiol is used analogously to study the sulfur chemistry in technical lignins. Coniferyl alcohol was synthesized in a large scale from commercially available ferulic acid by a mixed anhydride reduction method which affords high yields (84%) under very mild conditions and allows using sodium borohydride. The nucleophilic substitution of 4-O-acetylated coniferyl alcohol (3) with thioacetic acid in the presence of dimethylformamide (DMF) dineopentylacetal afforded 4-O-acetylated coniferyl thioacetate (5) in a 70% yield, which, in a 72% yield, was deprotected to the respective thiol (6). Both coniferyl alcohol and coniferyl thiol were comprehensively analytically characterized [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy]. The presented approach renders the two model substances readily available on a gram scale and according to low-risk, environmentally compatible protocols.
Autor/innen der BOKU Wien:
Amer Hassan
Bacher Markus
Mimini Vebi
Potthast Antje
Rosenau Thomas
BOKU Gendermonitor:


Find related publications in this database (Keywords)
coniferyl alcohol
coniferyl thiol
lignin
technical lignin


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