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Gewählte Publikation:

Heistinger, L; Gasser, B; Mattanovich, D.
(2020): Microbe Profile: Komagataella phaffii: a methanol devouring biotech yeast formerly known as Pichia pastoris
MICROBIOL-SGM. 2020; 166(7): 614-616. FullText FullText_BOKU

Methylotrophic yeasts of the genus Komagataella are abundantly found in tree exudates. Their ability to utilize methanol as carbon and energy source relies on an assimilation pathway localized in largely expanded peroxisomes, and a cytosolic metha-nol dissimilation pathway. Other substrates like glucose or glycerol are readily utilized as well. Komagataella yeasts usually grow as haploid cells and are secondary homothallic as they can switch mating type. Upon mating diploid cells sporulate readily, forming asci with four haploid spores. Their ability to secrete high amounts of heterologous proteins made them inter-esting for biotechnology, which expands today also to other products of primary and secondary metabolism.
Autor/innen der BOKU Wien:
Gasser Brigitte
Heistinger Lina
Mattanovich Diethard
BOKU Gendermonitor:

Find related publications in this database (Keywords)
budding yeast
yeast biotechnology
protein production

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