Selected Publication:

Chaube, MA; Trattnig, N; Lee, DH; Belkhadir, Y; Pfrengle, F.
(2022): Synthesis of Fungal Cell Wall Oligosaccharides and Their Ability to Trigger Plant Immune Responses
EUR J ORG CHEM. 2022; 2022(27), e202200313 FullText FullText_BOKU

Abstract:

Oligosaccharide fragments of fungal cell wall glycans are important molecular probes for studying both the biology of fungi and fungal infections of humans, animals, and plants. The fungal cell wall contains large amounts of various polysaccharides that are ligands for pattern recognition receptors (PRRs), eliciting an immune response upon recognition. Towards the establishment of a glycan array platform for the identification of new ligands of plant PRRs, tri-, penta-, and heptasaccharide fragments of different cell wall polysaccharides were prepared. Chito- and beta-(1 -> 6)-gluco-oligosaccharides were synthesized by automated glycan assembly (AGA), and alpha-(1 -> 3)- and alpha-(1 -> 4)-gluco-oligosaccharides were synthesized in solution using a recently reported highly alpha-selective glycosylation methodology. Incubation of plants with the synthesized oligosaccharides revealed i) length dependence for plant activation by chito-oligosaccharides and ii) beta-1,6-glucan oligosaccharides as a new class of glycans capable of triggering plant activation.

Authors BOKU Wien:

Pfrengle Fabian

Trattnig Nino

Find related publications in this database (Keywords)

Automated glycan assembly

Carbohydrate chemistry

Fungal cell wall

Pattern-triggered immunity

Plant immunity

Altmetric:

© BOKU Wien • Imprint