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Selected Publication:

Pircher, N; Fischhuber, D; Carbajal, L; Strauss, C; Nedelec, JM; Kasper, C; Rosenau, T; Liebner, F.
(2015): Preparation and Reinforcement of Dual-Porous Biocompatible Cellulose Scaffolds for Tissue Engineering
MACROMOL MATER ENG. 2015; 300(9): 911-924. FullText FullText_BOKU

Abstract:
Biocompatible cellulose-based aerogels composed of nanoporous struts, which embed interconnected voids of controlled micron-size, have been prepared employing temporary templates of fused porogens, reinforcement by interpenetrating PMMA networks and supercritical carbon dioxide drying. Different combinations of cellulose solvent (Ca(SCN)(2)/H2O/LiCl or [EMIm][OAc]/DMSO) and anti-solvent (EtOH), porogen type (paraffin wax or PMMA spheres) and porogen size (various fractions in the range of 100-500m) as well as intensity of PMMA reinforcement have been investigated to tailor the materials for cell scaffolding applications. All aerogels exhibited an open and dual porosity (micronporosity >100m and nanoporosity extending to the low micrometer range). Mechanical properties of the dual-porous aerogels under compressive stress were considerably improved by introduction of interpenetrating PMMA networks. The effect of the reinforcing polymer on attachment, spreading, and proliferation of NIH 3T3 fibroblast cells, cultivated on selected dual-porous aerogels to pre-evaluate their biocompatibility was similarly positive.
Authors BOKU Wien:
Almeria Ciarra
Fischhuber David
Kasper Cornelia
Liebner Falk
Pircher Nicole
Rosenau Thomas
Strauß Christine
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Find related publications in this database (Keywords)
cellulose aerogels
dual-porosity
porogens
supercritical anti-solvent precipitation
tissue engineering


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