University of Natural Resources and Life Sciences, Vienna (BOKU) - Research portal

Logo BOKU Resarch Portal

Selected Publication:

Haynes, BF; Fleming, J; St Clair, EW; Katinger, H; Stiegler, G; Kunert, R; Robinson, J; Scearce, RM; Plonk, K; Staats, HF; Ortel, TL; Liao, HX; Alam, SM.
(2005): Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.
Science. 2005; 308(5730):1906-1908 FullText FullText_BOKU

The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2175 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing, antibody responses by using HIV-1 vaccines.
Authors BOKU Wien:
Katinger Hermann
Kunert Renate
Find related publications in this database (using NML MeSH Indexing)
AIDS Vaccines - immunology
Animals - immunology
Antibodies, Monoclonal - immunology
Antibody Specificity - immunology
Autoantibodies - chemistry
Autoantigens - immunology
Autoimmune Diseases - immunology
Cardiolipins - immunology
Cell Line, Tumor - immunology
Epitopes - immunology
HIV Antibodies - chemistry
HIV Envelope Protein gp41 - chemistry
HIV Infections - immunology
HIV-1 - immunology
Humans - immunology
Mice - immunology
Molecular Mimicry - immunology
Neutralization Tests - immunology

© BOKU Wien Imprint