University of Natural Resources and Life Sciences, Vienna (BOKU) - Research portal
Selected Publication:
Haynes, BF; Fleming, J; St Clair, EW; Katinger, H; Stiegler, G; Kunert, R; Robinson, J; Scearce, RM; Plonk, K; Staats, HF; Ortel, TL; Liao, HX; Alam, SM.
(2005):
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.
Science. 2005; 308(5730):1906-1908
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- Abstract:
- The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2175 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing, antibody responses by using HIV-1 vaccines.
- Authors BOKU Wien:
- Katinger Hermann
- Kunert Renate
- Find related publications in this database (using NML MeSH Indexing)
- AIDS Vaccines - immunology
- Animals - immunology
- Antibodies, Monoclonal - immunology
- Antibody Specificity - immunology
- Autoantibodies - chemistry
- Autoantigens - immunology
- Autoimmune Diseases - immunology
- Cardiolipins - immunology
- Cell Line, Tumor - immunology
- Epitopes - immunology
- HIV Antibodies - chemistry
- HIV Envelope Protein gp41 - chemistry
- HIV Infections - immunology
- HIV-1 - immunology
- Humans - immunology
- Mice - immunology
- Molecular Mimicry - immunology
- Neutralization Tests - immunology
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