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Selected Publication:

Hofmann-Lehmann, R; Vlasak, J; Rasmussen, RA; Jiang, S; Li, PL; Baba, TW; Montefiori, DC; Bernacky, BJ; Rizvi, TA; Schmidt, R; Hill, LR; Keeling, ME; Katinger, H; Stiegler, G; Cavacini, LA; Posner, MR; Ruprecht, RM.
(2002): Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge.
J Med Primatol. 2002; 31(3):109-119

Simian-human immunodeficiency viruses (SHIV) allow the evaluation of antiviral strategies that target the envelope glycoproteins of the human immunodeficiency virus 1 (HIV-1) in macaques. We previously protected neonates from oral challenge with cell-free SHIV-vpu(+) by passive immunization with synergistic human neutralizing monoclonal antibodies (mAbs) (Baba et al., Nat Med 6:200-206, 2000). mAbs were administered prenatally to pregnant dams and postnatally to the neonates. Here, we used solely postnatal or postexposure mAb treatment, thus significantly reducing the amount of mAbs necessary. All neonatal monkeys were also protected with these abbreviated mAb regimens. Our results are directly relevant for humans because we used mAbs that target HIV-1 envelope glycoproteins. Thus, the large-scale use of passive immunization with neutralizing mAbs may be feasible in human neonates, The mAbs, being natural human proteins, can be expected to have low toxicity. Passive immunization has promise to prevent intrapartum as well as milk-borne virus transmission from HIV-1-infected women to their infants.
Authors BOKU Wien:
Katinger Hermann
Find related publications in this database (using NML MeSH Indexing)
Administration, Oral -
Animals -
Animals, Newborn - immunology
Antibodies, Monoclonal - immunology
Blotting, Western -
HIV - immunology
HIV Antibodies - immunology
Human Immunodeficiency Virus Proteins -
Humans -
Immunity, Mucosal -
Immunization, Passive - methods
Macaca mulatta - immunology
Simian Acquired Immunodeficiency Syndrome - immunology
Simian immunodeficiency virus - immunology
Time Factors -
Viral Load -
Viral Regulatory and Accessory Proteins - physiology

Find related publications in this database (Keywords)
mother-to-child transmission
primate model
synergistic neutralizing human anti-HIV-1
monoclonal antibodies

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